Clinical trials: Cognition Disorders in Old Age
Mild Cognitive Impairment
Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities
This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.
- Trial name
- NCT03195803
- Testing
- Computerized Cognitive Stimulation
- Volunteers
- 51 people
- Sponsor
- Leila DJABELKHIR
Mild Cognitive Impairment, Old Age; Debility
Dual Task Perturbation Training for OAwMCI
Studies have determined that compared to cognitively intact older adults (CIOA), older adults with mild cognitive impairment (OAwMCI) exhibit more pronounced balance and gait impairments which lead to an increased risk of falls…
- Trial name
- NCT04938349
- Testing
- Dual task perturbation training
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cognitive Dysfunction, Mobility Limitation
Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain…
- Conditions
- Cognitive Dysfunction, Mobility Limitation, Frail Elderly
- Trial name
- NCT05830942
- Testing
- Walking Exercise, Prefrontal Active tDCS
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Cognitive Impairment
Effects of Green Tea Consumption on Homocysteine Metabolism and Cognitive Dysfunction
Green tea contains catechins and theanine as major ingredients and has been reported to have various beneficial influences on human health.
- Trial name
- NCT01594086
- Testing
- green tea powder
- Where
- Japan
- Volunteers
- 15 people
- Sponsor
- University of Shizuoka
Cognitive Dysfunction, Memory Disorders in Old Age
Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment
The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is…
- Trial name
- NCT04558164
- Testing
- Active Theta Burst Stimulation
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, Los Angeles
Diabetes Mellitus, Type 2
The Effect of Aromatherapy on Cognitive Functions, Anxiety and Sleep
The aim of this study is to determine the effect of aromatherapy application on cognitive functions, anxiety and sleep quality in elderly people with diabetes.
- Trial name
- NCT04948931
- Testing
- Lavender aromatherapy, Rosemary aromatherapy, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of the Effectiveness and Safety of Transcranial Direct Current Stimulation in Combination With Nasal Near Infrared Stimulation to Improve Cognitive Functions and Quality of Life in Elderly People With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD).
Alzheimer's disease (AD) and mild cognitive impairment (MCI) are progressive neurodegenerative conditions with limited therapeutic options. Today, around 30 million people worldwide suffer from Alzheimer's dementia.
- Trial name
- NCT07290686
- Testing
- tDCS stimulation, tDCS, iNIRS stimulation
- Where
- Poland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Alzheimer Disease, Cognitive Impairment, Mild
Low Level Laser Therapy Impact on Cognitive Function and Quality of Life in Alzheimer Anemic Elderly Patients
Alzheimer's is a type of dementia that affects memory, thinking and behavior. Symptoms eventually grow severe enough to interfere with daily tasks.
- Trial name
- NCT04496778
- Testing
- low level laser therapy ( laser acupuncture combined with nasal laser irradiation), aerobic exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Hypopnea Syndrome, Apnea, Obstructive Sleep
Impact of Continuous Positive Airway Pressure Therapy on Bilateral Local Hippocampal Gray Matter Volume in Elderly Patients With Obstructive Sleep Apnea - Study BBBSAS
This study evaluates whether treating severe obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) for approximately 6 months modifies local hippocampal and frontal cortex gray matter volume and…
- Trial name
- BBBSAS (NCT07882433)
- Testing
- Continuous Positive Airway Pressure (CPAP) therapy, Multimodal brain MRI with Gadolinium injection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cognition Disorders in Old Age, Cardiovascular Diseases
The "Motoric Cognitive Risk" Syndrome in the Canadian Population
Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay…
- Conditions
- Cognition Disorders in Old Age, Cardiovascular Diseases, Dementia
- Trial name
- MCR-CardioV (NCT03679026)
- Testing
- Summarize of participants' characteristics using means and standard deviations or frequencies and percentages
- Where
- Canada
- Volunteers
- 1,461 people
- Sponsor
- Jewish General Hospital
Cognitive Impairment, Mild
Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects With Cognitive Impairment
A randomized, double-blind, placebo-controlled, two arm cross-over study to determine whether a specific combination of Andrographis paniculata and Withania somnifera can be regarded as a safe and effective treatment for…
- Trial name
- NCT03780621
- Testing
- Andrographis and Withania
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- EuroPharma, Inc.
Malnutrition, Falling
Identification of Risk Patients in Emergency Medical Services
Background: Inadequate nutrition has been associated with growing risk of falling and impaired ability in elderly patients. Falling is a significant threat to the health of the elderly.
- Conditions
- Malnutrition, Falling, Cognitive Impairment
- Trial name
- NCT03759314
- Testing
- Observation
- Where
- Finland
- Volunteers
- 500 people
- Sponsor
- Helsinki University Central Hospital
Emergence Delirium, Perioperative Neurocognitive Disorder
Quantitative Neurofeedback Techniques for Treating Perioperative Cognitive Disorders in Elderly Patients
The goal of this clinical trial is to learn if quantitative measurement of brain and neurofeedback intervention techniques works to prevent perioperative neurocognitive deficits in elderly oncology patients who are to undergo…
- Trial name
- NCT06752148
- Testing
- neurofeedback intervention training game
- Volunteers
- 390 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Insulin Resistance, Obesity
Metformin Effect on Brain Function in Insulin Resistant Elderly People
Alzheimer's disease (AD) and other forms of dementia are rapidly increasing with the aging of the population, and show a clear preponderance among people with insulin resistance.
- Conditions
- Insulin Resistance, Obesity, Obesity, Abdominal
- Trial name
- NCT03733132
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alzheimer's Disease, Mild Cognitive Impairment
Brain-Computer Interface System for Training Memory and Attention in Elderly
The primary objective is to examine the efficacy of 8-weeks of a locally developed brain-computer interface based system intervention for improving attention and memory in healthy elderly and those with age related cognitive…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Cognitive Decline, Dementia
- Trial name
- NCT02228187
- Testing
- Brain-Computer Interface
- Where
- Singapore
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Senile Plaques, Tau Proteins
Cognitive, Morphological and Neurobiological Progressive Aspects in Bipolar Disorders in the Elderly: Toward to a Neurodegenerescence Detection?
The purpose of this study is to identify association between cerebrospinal fluid Alzheimer's Disease's neurodegenerescence biomarkers (tau, ptau, Aß40 and Aß1-42) and occurrence of cognitive deficits in older patients with…
- Conditions
- Senile Plaques, Tau Proteins, Alzheimer Disease, Bipolar Disorders
- Trial name
- BIPAGE (NCT02843906)
- Testing
- Lombar Punction, Magnetic Resonance Imaging (MRI), Positron-Emission Tomography (TEP) /(FDG)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Grenoble
Cognitive Diseases
The Cognitive and Cardiovascular Health in the Elderly Study
The main objective of this study is to look for the interest forecast of the IPS as infra-clinical cardiovascular marker in the prediction of a change of the cognitive functions (MCI) at the elderly of 70 and more years old…
- Trial name
- COACHES (NCT01979432)
- Testing
- Cardiovascular evaluation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Limoges
Cognition Disorder, Nervous System Diseases
A Follow-up Study to Assess Safety and Tolerability of Galantamine Treatment in Individuals With Mild Cognitive Impairment
The purpose of this follow-up study is to assess the long-term safety and tolerability of galantamine in individuals with mild cognitive impairment who participated in a previous study with galantamine
- Conditions
- Cognition Disorder, Nervous System Diseases, Mental Disorders, Brain Diseases
- Trial name
- NCT00240695
- Testing
- galantamine hydrobromide
- Volunteers
- 724 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Gynecologic Cancer, Frailty
Cognitive and Physical Frailty as Predictors of Decision Satisfaction in Geriatric Gynecologic Oncology
This prospective observational study aims to evaluate the association between preoperative cognitive function, measured by the Montreal Cognitive Assessment (MoCA), and physical frailty, assessed using the Clinical Frailty Scale…
- Conditions
- Gynecologic Cancer, Frailty, Cognitive Impairment, Geriatric Oncology
- Trial name
- GYNCOGFRAIL (NCT07085000)
- Testing
- No Intervention - Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir City Hospital
Delirium, Postoperative Cognitive Dysfunction
Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients
Advanced age is a consistent risk factor for the incidence of postoperative cognitive decline, which is associated with longer hospital stays, decreased quality of life, and increased mortality.
- Trial name
- NCT06176144
- Testing
- Desflurane, Sevoflurane
- Where
- China
- Volunteers
- 890 people, healthy volunteers welcome
- Sponsor
- West China Hospital