Clinical trials: Cognition Disorders in Old Age
Mild Cognitive Impairment
WAVE: AudioVisual Stimulation Enhances Cognitive, Mental and Physical Health in Elderly
The goal of this randomized controlled trial is to 1) carry out a screening of cognitive function, depressive symptoms, agility and functional balance and chronic inflammatory conditions in older adults; 2) analyze the influence…
- Trial name
- NCT06686563
- Testing
- Intervention Group: Gamma stimulation, Control Group: Theta stimulation
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maria Paço
Technology, Cognitive Impairments
Tablet-based Interactive Games in Elderly With Cognitive Impairment and Persons With Intellectual Disability
The study has 10 research questions regarding the cognitive training program and tablet-based interactive games: Primary study questions: 1.
- Conditions
- Technology, Cognitive Impairments, Intellectual Disability
- Trial name
- NCT05822596
- Testing
- Tablet-based interactive games experimental group intervention
- Where
- 5 sites in Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery
PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery
This prospective observational study aims to evaluate whether intraoperative venous-to-arterial carbon dioxide partial pressure difference (PCO₂ gap) and arterial lactate levels can serve as early predictors of postoperative…
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07843186
- Volunteers
- 185 people
- Sponsor
- Ain Shams University
Depression - Major Depressive Disorder, Cognition Disorders in Old Age
Real-world Clinical Response to Trazodone in Italy, Poland, and Romania
TRACOMDD study is a study with the intention to describe the real-world use of trazodone and the clinical response in a sub-group of patients affected by Major Depressive Disorder and Mild Cognitive impairment, by collecting data…
- Trial name
- NCT07377682
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Balance Disorders, Accidental Falls
Population Cohort Set-up for the Epidemiological Assessment of Balance Disorders in Elderly People
As people age, it becomes more common to experience balance problems. These issues can increase the risk of falling, which may lead to serious health consequences and loss of independence.
- Conditions
- Balance Disorders, Accidental Falls, Frailty, Aging
- Trial name
- EPIBAS (NCT06965660)
- Where
- Spain
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Mild Cognitive Impairment
SYNchronizing Exercises, Remedies in Gait and Cognition at Home (SYNERGIC@Home)
Background: Prevention of Alzheimer's Disease and Related Dementias (ADRDs) may be possible for persons with subjective (SCI) or mild cognitive impairment (MCI), or normal cognition and risk factors.
- Trial name
- SYNERGIC@Hom (NCT04997681)
- Testing
- Combined Aerobic Exercise and Resistance Training (AE + RT), Cognitive Training (NeuropeakTM), Control Cognitive Training of Website Searching and Video Watching (WS+V)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of New Brunswick
Post-Operative Delirium, Postoperative Cognitive Dysfunction
Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery
The purpose of this study is to determine whether brain oxygenation measured by cerebral oximeter has an impact on neurocognitive dysfunction.
- Trial name
- NCT00991328
- Testing
- SctO2 < 60 %.
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications
Postoperative Cognitive Dysfunction in Geriatric Patients
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting.
- Conditions
- Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications, Memory Disorders
- Trial name
- NCT00512200
- Where
- Switzerland
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cognitive Decline, Cognitive Impairment
Preoperative Cognitive Training for Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction (POCD) is a state of decline in cognitive ability after surgery and is frequently seen among our elderly population.
- Conditions
- Cognitive Decline, Cognitive Impairment, Cognitive Deterioration
- Trial name
- CogniTrain (NCT03353987)
- Testing
- Cognitive training
- Where
- Malaysia
- Volunteers
- 17 people
- Sponsor
- University of Malaya
Brain Neoplasms, Delirium - Postoperative
Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor Patients
This study will compare three anesthesia medicines used to put people into a deep sleep during surgery: ciprofol, propofol, and sevoflurane. All three are commonly used for general anesthesia, but they work in different ways.
- Trial name
- NCT07799623
- Testing
- Ciprofol, Propofol, Sevoflurane
- Where
- China
- Volunteers
- 381 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Alzheimer Disease
Safety, Tolerability, and Pharmacokinetics Study of NDX-1017
This Phase 1 randomized, placebo-controlled, double-blinded, first-in-human study will evaluate safety, tolerability, and pharmacokinetics of single and multiple ascending doses of NDX-1017 in healthy young and elderly subjects…
- Trial name
- NCT03298672
- Testing
- NDX-1017
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- LeonaBio
Postoperative Cognitive Dysfunction
Ketamine and Changes of the Short Portable Mental Status Questionnaire
Cognitive changes are related to aging, affecting the performance of older patients in the solution of problems and the execution of tasks.
- Trial name
- SPMSQ-E (NCT02049411)
- Testing
- Ketamine, physiological solution
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Delirium, Cognitive Decline
Dexmedetomidine Use in ICU Sedation and Postoperative Recovery in Elderly Patients and Post-cardiac Surgery
Increasing numbers of elderly patients are undergoing cardiac surgery. Elderly patients may have prolonged recovery following cardiac surgery when compared to other groups of patients, and are at higher risk of postoperative…
- Conditions
- Delirium, Cognitive Decline, Post-operative Quality of Recovery
- Trial name
- DIRECT (NCT02699801)
- Testing
- propofol, Dexmedetomidine
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of British Columbia
General Anesthesia, Surgeries Requiring A Minimum One Day Hospitalization
How Lidocaine Affects Outcomes In Orthopedic Surgery Patients
This study will evaluate the effect of intraoperative lidocaine infusion on postoperative orientation and concentration in elderly patients having general anesthesia for orthopedic surgeries requiring a minimum 2 days…
- Conditions
- General Anesthesia, Surgeries Requiring A Minimum One Day Hospitalization, Elderly
- Trial name
- NCT01179100
- Testing
- Lidocaine
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Cognitive Dysfunction
Effect of Usage of Electroencephalogram (EEG) Entropy on the Incidence of Postoperative Cognitive Dysfunction in Geriatric Patients
To determine if the usage of EEG Entropy helps to reduces the incidence of POCD in elderly patients after general anesthesia.
- Trial name
- NCT00700674
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Khaled Eye Specialist Hospital
Dementia, Cognition Disorders in Old Age
Neuropsychological Assessment Of The Oldest-Old Population.(NEUROPSIC-GR)
Neuropsychological tests currently considered to evaluate the cognitive performance of the oldest-old population (more than 80 years) are not adapted to this group population.
- Trial name
- NEUROPSIC-GR (NCT05481749)
- Where
- 6 sites in Spain
- Volunteers
- 113 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Impaired Glucose Tolerance
Effects of Physical Activity on the Brain in Impaired Glucose Tolerance (IGT)
The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.
- Trial name
- NCT01219231
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Charite University, Berlin, Germany
Alzheimer Disease, Dementia
ADVANCE Study: Alzheimer Disease eVAluation iN Clinical PracticE
In 1906, Dr. Alois Alzheimer first described the disease that later took his name. Today, 100 years later, 24 million people worldwide suffer from Alzheimer's disease or other dementias.
- Conditions
- Alzheimer Disease, Dementia, Cognitive Disorders
- Trial name
- ADVANCE (NCT01772095)
- Where
- Greece
- Volunteers
- 389 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Aging, Aging Problems
Brain Health Virtual Reality Study
The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa.
- Conditions
- Aging, Aging Problems, Memory Loss, Memory Impairment
- Trial name
- NCT06124339
- Testing
- Physical Activity, Cognitive Activity (VR), Physical and Cognitive Activity
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Mild Cognitive Impairment, Mild Dementia
Dementia-friendly Apothecaries as a Resource for Mental Heath in the Elderly
The DARE study (Dementia-Friendly Apothecaries as a Resource for Mental Health in the Elderly) is a multicenter, prospective cohort study aiming to identify individuals with cognitive impairments early in pharmacies and enhance…
- Trial name
- DARE (NCT07504965)
- Where
- Germany
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich