Clinical trials: Cognitive Changes
Anxiety Disorders
A Clinical Trial of a Gamified Attention Bias Modification Training in Anxious Youth
Background: Attention bias modification training (ABMT) and cognitive behavioral therapy (CBT) likely target different aspects of aberrant threat responses in anxiety disorders and may be combined to maximize therapeutic benefit.
- Trial name
- NCT03283930
- Testing
- Active Attention Bias Modification Training
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Tetraplegia, Hypothermia
Effect of Heat Exposure on Cognition in Persons With Tetraplegia
The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (<95 F) have been documented in this population after exposure to even mild…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02488824
- Testing
- Warm Temperature
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Major Depression, Treatment
fMRI Study of Treatment Changes in Major Depression
The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional antidepressants do, and in comparison to healthy…
- Trial name
- NCT01027559
- Testing
- Sertraline, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Menopause
Estrogen and Serotonin on Changing Brain Chemistry
The aim of this study is to examine the effects of estrogen and serotonin on cognition, emotional processing, and brain activation.
- Trial name
- NCT01208324
- Testing
- estrogen patch, Amino acids
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cognitive Change
Impact of Challenging Engagement on Cognition in Older Adults
The study will enroll 90 participants in the "Impact of Challenging Engagement" study and assign them to one of three groups: high-demand photography, moderate-demand photography, and active placebo.
- Trial name
- engAGE (NCT03962439)
- Testing
- High-Demand Photography, Moderate-Demand Photography, At-Home Engagement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Cognitive Change
Patient Centered-Rehabilitation ver111090.1
As we age, a number of factors can reduce our cognitive (or thinking) abilities. This study will evaluate whether transcranial electrical stimulation (TES), which uses small amounts of electricity to modulate brain functioning…
- Trial name
- PCN1 (NCT03034954)
- Testing
- Active HD-tDCS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Mild Cognitive Impairment, Caregiver Burnout
Improving Physical Activity With Cognitive Impairment
Individuals with mild cognitive impairment are often physically inactive and at risk for progressing to dementia. Physical inactivity is considered a modifiable risk factor for dementia.
- Trial name
- NCT05370118
- Testing
- Telerehabilitation physical activity behavioral (TPAB) intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Creighton University
Mild Cognitive Impairment
Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.
- Trial name
- NCT04070703
- Testing
- The Go for Exercise & Healthy Aging Project
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Sedentary Behavior, Cardiovascular Risk Factor
Combined Effects of Prolonged Sitting and Mental Stress on the Cardiovascular System
Prolonged sitting may pose a public health risk through its effects on the cardiovascular system, and may lead to impaired whole-body cardiovascular health, which includes both vascular and cerebrovascular function.
- Conditions
- Sedentary Behavior, Cardiovascular Risk Factor, Mental Stress, Cognitive Change
- Trial name
- NCT04207333
- Testing
- Mental Arithmetic Test
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Parkinson Disease, Impaired Cognition
Cognitive Training in Parkinson Study
This study evaluates the efficacy of an eight-week online cognitive training program on objective and subjective cognitive functions in Parkinson's disease.
- Conditions
- Parkinson Disease, Impaired Cognition, Alteration in Cognition
- Trial name
- cogtips (NCT02920632)
- Testing
- Online cognitive training 1, Online cognitive training 2
- Where
- Netherlands
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Major Depressive Disorder, Cognitive Change
THINC-it Vortioxetine - Sensitivity to Change
The purpose of this study is to evaluate the sensitivity of the THINC-it tool, in measuring change in cognitive deficits in individuals with MDD after receiving vortioxetine.
- Trial name
- NCT03053362
- Testing
- Vortioxetine, THINC-it Tool
- Where
- Canada
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Brain and Cognition Discovery Foundation
Cognitive Change
Examining the Effectiveness of Cognitive Training
The present study addresses whether placebo effects can possibly account for previous findings in the field, as well as ascertains whether placebo-based mechanisms can be deliberately harnessed for impact.
- Trial name
- NCT04344028
- Testing
- True Cognitive Training Program, Control Cognitive Training Program, Positive Expectation Induction
- Where
- 3 sites in United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alteration of Cognitive Function, Dietary Modification
Cognitive Health Promotion Project in the Community
This study was based on baseline data derived from a large prospective study called the Suwon Project (SP), a cohort comprising random clustering samples of elderly people, all of whom are ethnic Koreans aged over 60 years.
- Trial name
- NCT01012947
- Testing
- Lifestyle Counseling Usual Care, Lifestyle Counseling Telephone, Bimonth, Lifestyle Counseling Telephone, Month
- Volunteers
- 1,115 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Cognitive Dysfunction, Cognitive Impairment
CAMCI: Advancing the Use of Computerized Screening in Healthcare
Cognitive impairment is a significant health problem in the United States, resulting in costs over $100 billion a year. We will provide an efficient, effective, and financially intelligent solution to Primary Care Physician's to…
- Conditions
- Cognitive Dysfunction, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- NCT03512301
- Testing
- CAMCI, MoCA, Clinical Adjudication
- Where
- 4 sites in United States
- Volunteers
- 773 people, healthy volunteers welcome
- Sponsor
- Psychology Software Tools, Inc.
Coronary Heart Disease, Cardiac Rehabilitation
Reducing Risk in Cardiac Rehabilitation: Partners Together in Health (PaTH) Intervention Study
The objective of the proposed study, using an experimental, two-group (n = 30 couples in each group) repeated measures design, was to pilot test the effects of the PaTH Intervention versus a usual care group in improving the…
- Trial name
- PaTH (NCT00926848)
- Testing
- Partners Together in Health (PaTH) Intervention
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cognitive Change, Health Behavior
A Multidomain Approach to Preventing Dementia in African Americans: Cognitive Prescriptions
The goal of this R21 study is to explore the feasibility and preliminary efficacy of individualized cognitive prescriptions (CogRxs) in improving engagement in healthy behaviors and other outcomes in middle-aged AAs and to gain…
- Conditions
- Cognitive Change, Health Behavior, Health Literacy
- Trial name
- NCT03864536
- Testing
- Cognitive Prescriptions
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Alzheimer's Disease
Dose Response Study of Aerobic Exercise in Older Adults
This is a randomized, 26-week study of supervised exercise assessing three doses of exercise in sedentary individuals 65 years of age and over with age-related cognitive changes.
- Trial name
- NCT01129115
- Testing
- Nonexercise control group, Aerobic Exercise Group 1, Aerobic Exercise Group 2
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Jeff Burns, MD
Cognitive Change
Transcranial Near-Infrared Light in Healthy Subjects: a Cerebral Blood Flow Study With Diffuse Correlation Spectroscopy
Transcranial Light Therapy involves non-invasive and invisible beams of light that increase energy metabolism in the brain. Transcranial light therapy has been found to promote brain metabolism.
- Trial name
- NIR-Flow (NCT03740152)
- Testing
- Transcranial Light Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stroke, Frailty
Pilot of Cognitive Stimulation Therapy for Pre-frail Stroke Survivors
Frailty is described as a type of vulnerability where one can struggle to recover fully from things that can put stress on one\'s body, e.g., cold weather or bronchitis.
- Conditions
- Stroke, Frailty, Carers
- Trial name
- NCT06733103
- Testing
- Stroke Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Memory Loss, Cognitive Changes
Aging and Estrogen on Cortical Function
This study will focus on how estrogen affects parts of the brain associated with memory and how the effect of estrogen is altered with aging in postmenopausal women.
- Conditions
- Memory Loss, Cognitive Changes, Postmenopausal Symptoms
- Trial name
- NCT01268046
- Testing
- Estradiol oral capsule, transderman estrogen patch
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital