Clinical trials: Cognitive Decline
Neurocognitive Disorders, Dementia
Care at 360º: A Long-term Individual Cognitive Stimulation Program
The aim of the intervention proposed in the present study is to assess the effect of a cognitive stimulation (CS) intervention program in an individual and long-term format, for non-institutionalized elderly people with…
- Conditions
- Neurocognitive Disorders, Dementia, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT04417751
- Testing
- Cognitive Stimulation
- Where
- Portugal
- Volunteers
- 59 people
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Subjective Cognitive Decline
Preventing Cognitive and Functional Decline Among Seniors at Risk
This study evaluates the efficacy of Real-World Strategy Training (RWST) compared to a psycho-education workshop for improving everyday life performance in older adults with subjective cognitive decline (SCD).
- Trial name
- NCT03495037
- Testing
- Real World Strategy Training, Psychosocial Education
- Where
- Canada
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Baycrest
Subjective Cognitive Decline
Effects of Online Training Aimed at Increasing Participation in Everyday Life During a Pandemic (SCD Online).
This study evaluates the efficacy of Real-World Strategy Training (RWST) compared to a psycho-education workshop for improving everyday life performance in older adults with subjective cognitive decline (SCD).
- Trial name
- NCT04439500
- Testing
- Real World Strategy Training, Brain Education
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baycrest
Hypertension, Cognitive Decline
Remote Monitoring and Virtual Collaborative Care For Hypertension Control To Prevent Cognitive Decline
This purpose of this study is to examine an aggressive method of blood pressure control that involves home blood pressure monitoring and management of medications by a team of clinical pharmacists in coordination with a primary…
- Trial name
- vCCC (NCT04585880)
- Testing
- Virtual Collaborative Care Clinic
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Kansas Medical Center
Age Related Cognitive Decline, Age Related Macular Degeneration
Walnuts and Healthy Aging
This will be a systematic investigation of the role of walnuts in preventing or slowing age related cognitive decline and age related macular degeneration.
- Trial name
- WAHA (NCT01634841)
- Testing
- Walnuts, habitual diet
- Where
- 2 sites in United States, Spain
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Cognitive Decline
Analysis of Inflammatory Predictors and Gene Expression in Patients With Mild Cognitive Impairment
A randomized, double-blind, placebo-controlled clinical trial will be conducted, using data from participants who met the diagnostic criteria for mild cognitive impairment and who participated in a primary clinical trial that…
- Trial name
- NCT04934423
- Testing
- Direct Current Transcranial Stimulation - tDCS
- Volunteers
- 40 people
- Sponsor
- Federal University of Paraíba
Cognitive Decline
Open-Label Study of Omega 3 Oil Supplementation for Aging-Related Cognitive Decline
Aging-related cognitive decline may be affected by brain cholesterol and the health of cell membranes. Certain nutritional supplements have been proposed to support membrane health, and there is increasing interest in…
- Trial name
- NCT04484454
- Testing
- ProdromeNeuro Omega 3 Oil Nutritional Supplement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Neurological Associates of West Los Angeles
Myocardial Infarction, Unstable Angina
CORonary Diet Intervention With Olive Oil and Cardiovascular PREVention
The purpose of this study is to compare the effects of the consumption of two different dietary patterns (low fat versus Mediterranean Diet) on the incidence of cardiovascular events of persons with coronary disease.
- Conditions
- Myocardial Infarction, Unstable Angina, Malignancy, Cognitive Decline
- Trial name
- CORDIOPREV (NCT00924937)
- Testing
- Mediterranean Diet, Low Fat Diet
- Where
- Spain
- Volunteers
- 1,002 people
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Cognitive Dysfunction, Cognitive Aging
Three-month Chan-Chung Qigong Improves Physical Function Performance and Quality of Life
The purpose of this study aimed to evaluate the effect of the three-month Chan-Chung qigong program in improving physical functional performance and quality of life in patients with mild to moderate cognitive impairments.A…
- Conditions
- Cognitive Dysfunction, Cognitive Aging, Grip, Exercise Training
- Trial name
- NCT04904991
- Testing
- Chan-Chuang qigong
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Aging, Sarcopenia
PANGeA - Physical Activity and Nutrition for Quality Ageing
General objectives of the project Defining healthy ageing factors; Setting up content-related bases of the international excellence centre (SLO-ITA) in the field of health of elderly citizens; Raising awareness on the…
- Conditions
- Aging, Sarcopenia, Cognitive Decline
- Trial name
- PANGeA_MM (NCT04899531)
- Testing
- Longitudinal observation
- Where
- Slovenia
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Biomarkers, Cognitive Assessment
Neuropsychological Indicators of SCD Progression
Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified.
- Conditions
- Biomarkers, Cognitive Assessment, Cognitive Decline, Neurocognitive Disorders
- Trial name
- SCD-CI (NCT04880252)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Subjective Cognitive Decline
Polyamine-enriched Diet in Healthy Older Adults With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance of individuals with subjective cognitive decline.
- Trial name
- preSmartAge (NCT02755246)
- Testing
- Polyamine supplementation
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Subjective Cognitive Decline (SCD)
Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance and further characterization of individuals with subjective cognitive decline.
- Trial name
- SmartAge (NCT03094546)
- Testing
- Polyamine
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Cognitive Decline
Evaluation of Cognitive State Using Neurosteer EEG System
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through EEG recordings while listening to an…
- Trial name
- NCT04386902
- Testing
- Neurosteer Aurora system
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neurosteer Ltd.
Atrial Fibrillation, Dementia
PLUG Dementia Trial and MRI PLUG Dementia Sub-Study
PLUG Dementia Trial: Patients will be screened at Intermountain Medical Center and at Intermountain affiliated anticoagulation clinics in the Salt Lake City region.
- Conditions
- Atrial Fibrillation, Dementia, Cognitive Decline
- Trial name
- NCT03091855
- Testing
- Questionnaire, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Intermountain Health Care, Inc.
Cognitive Decline, Intracerebral Hemorrhage
Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) Cognitive Sub-Study
A Sub-Study of an investigator initiated and conducted, multicentre, international, double-blinded, placebo-controlled, parallel-group, randomised controlled trial (TRIDENT) to determine the effect of more intensive long-term…
- Conditions
- Cognitive Decline, Intracerebral Hemorrhage, Dementia, Vascular, Cerebral Small Vessel Diseases
- Trial name
- TRIDENT COG (NCT03785067)
- Testing
- telmisartan 20mg + amlodipine 2.5mg +indapamide 1.25mg
- Where
- 4 sites in Australia, Netherlands
- Volunteers
- 1 people
- Sponsor
- The George Institute
Breast Cancer, Cognitive Symptoms
Breast Cancer Patients' Cognitive Symptoms After Information About Chemotherapy-Related Cognitive Symptoms
Previous cross-sectional studies have shown that informing cancer patients about potential chemotherapy-related cognitive symptoms may negatively affect perceived cognitive symptoms and verbal memory performance.
- Conditions
- Breast Cancer, Cognitive Symptoms, Cognitive Decline
- Trial name
- CONTEXT (NCT04813965)
- Testing
- Written information about potential chemotherapy-related cognitive symptoms without self-affirmation, Written information about potential chemotherapy-related cognitive symptoms with self-affirmation
- Volunteers
- 148 people
- Sponsor
- Radboud University Medical Center
Cognitive Decline, Aging
Dietary Reduction of AGEs to Prevent Cognitive Decline in Elderly Diabetics
Basic science and observational human studies suggest that high conentrations of circulating Advanced Glycation End-products (AGEs) may promote cognitive decline in older adults.
- Conditions
- Cognitive Decline, Aging, Type 2 Diabetes
- Trial name
- NCT02739971
- Testing
- Low AGEs diet, Standard of care dietary guidance for Type 2 diabetes
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Sheba Medical Center
Ischemic Stroke, Cerebral Small Vessel Disease
Remote Preconditioning Over Time To Empower Cerebral Tissue
Previous studies in animals and humans has shown that brief periods of reduced blood flow to one organ or tissue in the body can help protect other tissues from subsequent injury caused by reduced blood flow such as a stroke.
- Conditions
- Ischemic Stroke, Cerebral Small Vessel Disease, Cognitive Decline
- Trial name
- REM-PROTECT (NCT02169739)
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, Los Angeles
Healthy Aging, Cognitive Change
The Effect of Transcranial Direct Current Stimulation on Visual Attention - Single Sessions
Recently, attention has been drawn to non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), in order to enhance cognitive functions by modifying brain plasticity and use it in…
- Conditions
- Healthy Aging, Cognitive Change, Cognitive Decline
- Trial name
- NCT04134195
- Testing
- Transcranial direct current stimulation
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Masaryk University