Clinical trials: Cognitive Decline
Physical Activity, Age-related Cognitive Decline
The Effect of Age, Physical Fitness and a Single Bout of Aerobic Exercise on Motor and Cognitive Functions
The proposed study is intended to examine the connection between two types of inhibition - cognitive and motor and the connection between motor inhibitory functions and a single bout of physical exercise in the context of age and…
- Trial name
- NCT03750812
- Testing
- Aerobic Exercise, Watching television
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Subjective Cognitive Decline
Neurotrack Virtual Cognitive Health Study
The Neurotrack Virtual Cognitive Health Study is a 12-month long, prospective study that aims to evaluate the impact of the Neurotrack Virtual Cognitive Health Coaching Program on cognitive ability, anxiety and depression, and…
- Trial name
- NCT02969460
- Testing
- Neurotrack Virtual Cognitive Health Program
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Evidation Health
Cognitive Decline
Cognitive Function in Elderly Marathon Runners
There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly.
- Trial name
- APSOEM (NCT01045031)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cognitive Decline, Neurophysiologic Abnormality
Effects of a Food Supplement on Cognitive and Neuropsychological Functioning in Older Adults.
The increase in life expectancy is associated with a gradual aging of the population so creating new needs arising from this new situation.
- Trial name
- NCT03145987
- Testing
- Vitis vinifera extract
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Cognitive Decline
Mind-motor Exercise to Improve Cognition and Functional Fitness
This is a 3 month cluster randomized controlled trial using a square-stepping exercise program (a.k.a. mind-motor exercise) in retirement and long-term care residences to improve global cognitive functioning in older adults with…
- Trial name
- MIND-FUN (NCT02730013)
- Testing
- Square Stepping Exercise
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Cognitive Impairment, Cognitive Decline
Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)
This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognition Disorders, Cognitive Symptom
- Trial name
- MoCA-Norm (NCT03246269)
- Testing
- MoCA
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Andreas Monsch
Cognitive Decline, Dementia
Group Reminiscence Therapy for Elderly People With Cognitive Decline in Institutional Context
The project presented here respond to this emerging need by implementing a Reminiscence Therapy program dedicated to elderly people in an institutional context.
- Conditions
- Cognitive Decline, Dementia, Cognitive Impairment
- Trial name
- NCT03370796
- Testing
- Reminiscence Therapy Program
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Escola Superior de Enfermagem de Coimbra
Cognitive Decline, Memory Loss
Effects of Music and Dance on Cognition, Frailty, and Burden in Elderly Caregivers Living in Rural Communities
This research aims to analyze the effects of senior dance on the cognition, frailty, and burden in elderly caregivers of rural communities.
- Conditions
- Cognitive Decline, Memory Loss, Frail Elderly Syndrome, Burden, Dependency
- Trial name
- NCT03068299
- Testing
- Dance, Health care guidance
- Where
- Brazil
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Delirium in Old Age, Cognitive Decline
Informant Questionaire on Cognitive Decline in the Elderly (IQCODE) and Delirium in Geriatric Patients
To investigate the usefulness of the Informant Questionaire on Cognitive Decline in the Elderly (IQCODE) to predict delirium in elderly patients admitted to Emergency Department (ED) with geriatric assessment and transferred to…
- Trial name
- Delirium (NCT03175276)
- Where
- Denmark
- Volunteers
- 315 people
- Sponsor
- Aarhus University Hospital
Dementia, Cognitive Decline
Choral Singing For the Prevention of Dementia
To evaluate the efficacy of choral singing in the prevention of dementia and examine the underlying mechanisms using Magnetic Resonance Imaging (MRI) technique and a panel of peripheral biomarkers in venous blood and urine.
- Trial name
- NCT02919748
- Testing
- Choral Singing, Health Education Program
- Where
- Singapore
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cancer, Prostate Cancer
Physicians' Health Study II
The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring.
- Conditions
- Cancer, Prostate Cancer, Colorectal Cancer, Cardiovascular Disease
- Trial name
- PHS II (NCT00270647)
- Testing
- Vitamin E, Vitamin C, Multivitamin
- Volunteers
- 14,641 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Aging, Physical Activity
Exercise Periodization and Older Adults
The present study aimed at investigating the effects of two different resistance training protocols - nonperiodized (NP) and daily undulating periodization (DUP) - on hemodynamic, morphofunctional and cognitive parameters of…
- Conditions
- Aging, Physical Activity, Sarcopenia, Cognitive Decline
- Trial name
- NCT03443375
- Testing
- Physical exercise
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Cognitive Decline
Adult Broad Learning Experiment (ABLE): Feasibility Study
This study evaluates the feasibility of enrolling and retaining older adults in a 15-week intervention that will implement six factors from early childhood experiences: individualized scaffolding (having a responsive teacher)…
- Trial name
- ABLE (NCT03438136)
- Testing
- Adult Broad Learning Experiment (ABLE)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Aging, Cognitive Decline
The Effect of a Single Bout of Balance and Coordination Exercise on Cognitive Function in Elderly People
Individuals of advanced age are at higher risk of cognitive deterioration.A single bout of aerobic exercise was found to improve cognitive functions.
- Trial name
- NCT03420365
- Testing
- Aerobic exercise
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Dementia of the Alzheimer Type, Age-related Cognitive Decline
Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration
DEPEND is an open-label but dosage-masked trial of the retired cholesterol-lowering drug probucol as an agent to increase availability of apolipoprotein E (apoE) in the cerebrospinal fluid (CSF) of cognitively intact older…
- Conditions
- Dementia of the Alzheimer Type, Age-related Cognitive Decline, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- DEPEND (NCT02707458)
- Testing
- Probucol
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Taurine, Cognitive Decline
Taurine Supplementation on Cognitive Function in Patients With Diabetes
Diabetes has become important risk factors for threatening human life and health. Studies have shown that chronic hyperglycemia lead to microvascular brain injury. The more common types of dementia are Alzheimer's disease (AD).
- Conditions
- Taurine, Cognitive Decline, Diabetes Mellitus
- Trial name
- NCT03410173
- Testing
- Taurine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Military Medical University
Age-related Cognitive Decline
Attention Training for Learning Enhancement and Resilience Trial
Healthy aging is associated with a decline in multiple cognitive domains, as well as motor control function. The long-term consequences of cognitive and functional impairment resulting from age-related cognitive decline are well…
- Trial name
- ALERT (NCT02416401)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- Posit Science Corporation
Cognitive Decline
Evaluating the Impact of Cerebral Ischemic And Degenerative Changes On Cognition
The purpose of this study is to evaluate whether or not cerebral atrophy scores obtained from a brain MRI can correlate with Cognitive Test results.
- Trial name
- NCT00704327
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Lahey Clinic
Cognitive Decline, Cognitive Impairment
Serum, Dietary and Supplemental Vitamin D's Association With Cognitive Decline
Serum 25(OH)D, dietary and supplemental vitamin D were shown to influence cognitive outcomes in large epidemiological studies. Sex/age-specific and race-specific associations of vitamin D status and intake were examined with…
- Trial name
- NCT03320109
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 3,720 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Metabolic Disorders and Cognitive Decline
Effects of Whole Grain Rye on Metabolic Risk Markers and Mood
The purpose of the study is to investigate, in healthy middle age subjects, effects of whole grain rye on cognitive functions, mood, and cardiovasculair risk markers
- Trial name
- NCT03275948
- Testing
- whole grain, reference
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lund University