Clinical trials: Cognitive Decline
MCI
Motor-cognitive Interventions Are Effective in Improving Cognitive Function in Older Adults With Mild Cognitive impairment--a Chinese Sample
Mild cognitive impairment (MCI) is a syndrome that occurs in the preclinical stage of Alzheimer, and early intervention can be effective in preventing Alzheimer, but further research is needed on intervention methods.
- Trial name
- NCT05764421
- Testing
- motor-cognitive intervention
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Jinxuan Cheng
Stroke, Stroke (CVA) or TIA
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors.
- Conditions
- Stroke, Stroke (CVA) or TIA, Dementia, Vascular, Cerebrovascular Disorders
- Trial name
- IC3 (NCT05885295)
- Testing
- MRI brain, Blood tests, cognitive assessments
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Mild Cognitive Impairment
Intervention Effect of Yizhi Baduanjin on Patients With Mild Cognitive Impairment
With mild cognitive impairment (MCI) as the research object, the intervention effect of Yizhi Baduanjin on mild cognitive impairment was evaluated by using the Montreal Cognitive Assessment (MoCA) scale, human-computer…
- Trial name
- NCT05899777
- Testing
- Yizhi Baduanjin
- Volunteers
- 100 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Mild Cognitive Impairment
Exercise Training to Improve Cognitive Function
This project is assessing the feasibility of a novel home-based exercise intervention to improve episodic memory in individuals with mild cognitive impairment.
- Trial name
- NCT03824639
- Testing
- Structured exercise, Health Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Cognitive Dysfunction
Dexmedetomidine and Esmolol Early Post Operative Cognitive Dysfunction
Dexmedetomidine is a highly selective α2adrenoceptor agonist recently introduced to anesthesia that produces dose dependent sedation, anxiolysis, and analgesia (involving spinal and supraspinal sites) without respiratory…
- Trial name
- NCT03892512
- Testing
- Esmolol Hydrochloride, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Beni-Suef University
Mild Cognitive Impairment, Mild Dementia
A Study to Evaluate the Effects of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance in participants with Alzheimer's Disease.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Alzheimer's Disease
- Trial name
- NCT05619692
- Testing
- SAGE-718
- Where
- 39 sites in United States, Puerto Rico
- Volunteers
- 174 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Psychological Stress, Mental Fatigue
Psychophysiological Effects of Green Exercise in Outdoor Green vs. Indoor Control
Core Purpose: Researchers want to learn if walking in an outdoor green environment helps people recover from mental tiredness and stress better than walking indoors.
- Conditions
- Psychological Stress, Mental Fatigue, Cognitive Dysfunction, Emotional Well-being
- Trial name
- GREEN-OI (NCT07379164)
- Testing
- Outdoor Green Group, Indoor Control Group
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lincoln University College
Systemic Lupus Erythematosus
Memory and Attention Problems in Lupus: New Treatment Trial With Modafinil
This study is being conducted in order to determine if the FDA-approved drug Modafinil can improve cognitive function in patients with lupus.
- Trial name
- NCT00297284
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hospital for Special Surgery, New York
Migraine Headache, Cognitive Impairment
Treximet in Acute Migraine Headache: Assessing Cognitive Function
Migraine headache occurs frequently in women more than men and is associated with symptoms not only of significant pain but also of symptoms typically including of photophobia, phonophobia, nausea and vomiting.
- Trial name
- NCT00837044
- Testing
- Treximet, Migraine rescue medication of choice
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Neurological Research Center
Mild Cognitive Impairment (MCI)
Cognitive-Frailty Gait Biomechanics for Early Dementia Detection
The purpose of this study is to better understand how physical characteristics, walking patterns, and a blood-based brain health marker differ between older adults with dementia and healthy older adults.
- Trial name
- gait dementia (NCT07448909)
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Ischemic Stroke, Blood Pressure
Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Stroke Patients
Elevated blood pressure (BP) consists of a major public health concern especially in low and middle income countries. Besides being a highly prevalent condition, it is also a risk factor for several major cardiovascular events…
- Conditions
- Ischemic Stroke, Blood Pressure, Cognitive Impairment, Vascular Diseases
- Trial name
- OPTIMAL Stroke (NCT04036409)
- Testing
- Intensive Control of Systolic Blood Pressure (SBP), Standard control of Systolic Blood Pressure (SBP)
- Where
- 30 sites in Brazil
- Volunteers
- 4,368 people
- Sponsor
- Hospital Israelita Albert Einstein
COPD
Cognitive Impairment in COPD Patients
Prior researches suggest the presence of impaired lung function may be linked to cognitive impairment (CI). A recent study shows that lung disease, and specifically Chronic obstructive pulmonary disease (COPD) are associated to a…
- Trial name
- RESCOG (NCT04394299)
- Where
- Italy
- Volunteers
- 1,476 people
- Sponsor
- IRCCS San Raffaele
Cognitive Ability, General, Brain Health
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65…
- Conditions
- Cognitive Ability, General, Brain Health, Cerebral Oxygenation
- Trial name
- HYPOX-AGE (NCT06874387)
- Testing
- Hypoxia, intermittent, physical exercise
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ayoub Boulares
POCD - Postoperative Cognitive Dysfunction
Correlation Between Postoperative Cognitive-related Adverse Reactions and Brain Metabolomic Characteristics in Elderly Patients
Postoperative cognitive dysfunction (POCD) refers to the difficulties of orientation, cognition, communication, memory and abstract thinking of patients after anesthesia and surgery.
- Trial name
- NCT05555693
- Testing
- Collecting clinical data, EGG，Brain Metabolomic Characteristics(with Magnetic Resonance Spectroscopy), blood gas data and blood sample
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline
This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and…
- Conditions
- Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Aging, Healthy
- Trial name
- NCT05014893
- Testing
- multi-modal targeted intervention (e.g., cognitive training, exercise, games)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Research Center for Rehabilitation Technical Aids
Rheumatoid Arthritis, Pain
Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients
The purpose of this study is to investigate how RA affect the brain structures in RA-patients and if anti-inflammatory treatment that target TNF-α or JAK OR physical training of hands has positive impact on neuropsychiatric…
- Conditions
- Rheumatoid Arthritis, Pain, Fatigue, Cognitive Decline
- Trial name
- NeuMRA (NCT04378621)
- Testing
- TNF-α inhibitor OR JAK inhibitor, Hand training
- Where
- Sweden
- Volunteers
- 212 people
- Sponsor
- Vastra Gotaland Region
Cognitive Impairment, Depression
Omega-3 Unsaturated Fatty Acid Improves Cognitive Function in Patients With Depression
The aim of this study was to evaluate the effect of n-3pufas on cognitive function in patients with depression
- Trial name
- NCT04803071
- Testing
- Experimental group of n-pufas improving cognitive formula, General fish oil formula product adjuvant treatment control group
- Where
- China
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Hepatitis C
Cognitive Impairments in Chronic Hepatitis C Patients and Potential Reversibility With New Agents (CICHepC)
The overall aim of this study is to evaluate the prevalence of cognitive impairments and brain anomalies in Chronic Hepatitis C infected individuals and to investigate likely changes in cognition and brain structure and function…
- Trial name
- CICHepC (NCT02745132)
- Testing
- Neuropsychological evaluation and Brain MRI
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Bipolar II Disorder
add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients
The investigators hypothesized that add-on memantine (MM) 5 mg/day may reduce chronic inflammation, and subsequently improve neuro-progression process and cognitive function in middle-to-old aged bipolar II disorder (BP-II)…
- Trial name
- NCT04035798
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Obesity, Healthy Aging
Sukalmena InAge: Nutritional-culinary Programme to Promote Adherence to a Healthy Dietary Pattern.
Currently, one of the main health challenges of public health is to improve the quality of life of people with chronic non-communicable diseases, through new strategies that promote healthy eating habits and lifestyles.
- Conditions
- Obesity, Healthy Aging, Cognitive Impairment
- Trial name
- Sukalmena (NCT04908163)
- Testing
- Mediterranean diet-based nutritional education intervention, Mediterranean diet-based culinary intervention
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Basque Culinary Center Fundazioa