Clinical trials: Cognitive Decline
Mild Traumatic Brain Injury, Cognitive Impairment
The Effect of Cognitive Rehabilitation Therapy in Improving Cognitive Function of Attention Following Mild Traumatic Brain Injury
This research is a randomised controlled study. The study hypothesis is cognitive rehabilitation for attention deficits following mild traumatic brain injury will improve patient's cognitive outcome, measured by…
- Trial name
- NCT03237676
- Testing
- Structured cognitive rehabilitation therapy, Patient-centred cognitive therapy
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- University of Malaya
Breast Cancer, Cognitive Dysfunction
eHealth Interventions for Breast Cancer Cognitive Impairment
This study investigates the effectiveness of integrating a cognitive rehabilitation module into a digital psychosocial intervention for recently diagnosed breast cancer patients.
- Trial name
- ICOgnition (NCT06103318)
- Testing
- ICOgnition
- Volunteers
- 176 people
- Sponsor
- Institut Català d'Oncologia
Cognitive Impairment, Mild, Dementia
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo.
- Conditions
- Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
- Trial name
- PREVENTABLE (NCT04262206)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 106 sites in United States, Puerto Rico
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Risk Behavior, Cognitive Decline
Efficacy of a Multidomain Intervention on Lifestyle Risk Factors for Dementia Prevention
Alzheimer's Disease (AD) and other Dementias have far-reaching consequences on the lives of sufferers and their loved ones, not to mention the impact on the healthcare system.
- Trial name
- NCT06748625
- Testing
- Luci Coach-Assisted Intervention
- Where
- Canada
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- LuciLab
Dementia Disorders, Mild Cognitive Impairment (MCI)
Multimodal Biomarkers in Individual With Cognitive Impairment and Dementia
Memory problems can range from normal aging to mild cognitive impairment (MCI) to dementia. This study looks at three ways of measuring what is happening in the brain at each of these stages: a blood test (GFAP), a brain MRI…
- Trial name
- NCT07812480
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Stroke, Cognition
Turkish Version of the Brief Assessment of Cognitive Impairment in Individuals With Stroke Scale
Cognitive processing involves many interrelated cognitive domains, such as performing daily tasks, attention, language, and memory. 70% of individuals with stroke experience cognitive problems.
- Trial name
- NCT06313021
- Testing
- Reliability and Validity Study
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ataturk University
Cognitive Impairment
Virtual Reality-Assisted Reminiscence Therapy in Older Adults With Cognitive Impairment
This study evaluated whether immersive virtual reality (VR) could enhance the effects of reminiscence therapy in older adults with cognitive impairment attending day-care services.
- Trial name
- NCT07825909
- Testing
- Virtual Reality-Assisted Reminiscence Therapy, Traditional Reminiscence Therapy
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Universitario Salesiano Venezia-Mestre (IUS)
Cognitive Impairment, Cognitive Decline
Cognitive Screening Made Easy for PCPs - Administrative Supplement
This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care.
- Conditions
- Cognitive Impairment, Cognitive Decline, Dementia, Mild
- Trial name
- NCT06928298
- Testing
- RACS app
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Cognitive Impairment, Hematologic Malignancy
Diet and Cognitive Training in Hematologic Cancer Survivors
The goal of this clinical trial is to examine feasibility of a cognitive intervention program in blood cancer survivors. The main questions it aims to answer are: is it feasible to combine a ketogenic diet supplementation and…
- Trial name
- NCT05708716
- Testing
- Modified ketogenic diet using an exogenous ketogenic formula, Online cognitive training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Insomnia, Cognitive Dysfunction
Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
This randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals…
- Conditions
- Insomnia, Cognitive Dysfunction, Mild Cognitive Impairment, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT05565833
- Testing
- SHUTi OASIS, Patient Education
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Virginia
Amnestic Mild Cognitive Impairment, Interactive Stepping Exercise
Interactive Stepping Exercise on Memory
This is a randomized controlled trail. A total of 28 individuals with aMCI will be randomly assigned to either the ISE group or control group. The ISE intervention conducts three times a week for 16 weeks.
- Conditions
- Amnestic Mild Cognitive Impairment, Interactive Stepping Exercise, Memory, Cognitive Function
- Trial name
- NCT04103463
- Testing
- Interactive stepping exercise, Home exercise
- Volunteers
- 30 people
- Sponsor
- National Yang Ming Chiao Tung University
Cognitive Impairment
Improving Surgical Safety of Seniors Through Preoperative Cognitive Screening
The hypothesis is that structured preoperative cognitive screening of seniors is feasible without specialized staff and can help preoperatively identify persons at high risk of complications.
- Trial name
- NCT02570438
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Post Traumatic Stress Disorder, Attention Deficit Hyperactivity Disorder
Atomoxetine in Veterans With Comorbid ADHD/PTSD
The current available treatments for PTSD are not fully effective for cognitive symptoms of PTSD and have high drop-out and poor engagement, two factors found to be most indicative of overall return to functioning for patients…
- Trial name
- NCT02287038
- Testing
- Atomoxetine 80 MG
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury (TBI) Patients, Cognitive Impairment
Mindfulness-Integrated Neuropsychotherapy for Traumatic Brain Injury: A Mixed-Methods Evaluation of Cognitive and Psychosocial Recovery
The goal of this clinical trial is to test the effectiveness of Integrative Mindfulness Enhanced Neuropsychotherapy (IMENP) in improving neurocognitive functioning and wellbeing among adults aged 18 to 44 years with mild to…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Cognitive Impairment, Depression Disorder, Fatigue Severity Scale
- Trial name
- IMENP (NCT07874685)
- Testing
- Integrative Mindfulness Enhanced Neuropsychotherapy (IMENP)
- Where
- India
- Volunteers
- 68 people
- Sponsor
- University of Madras
Delirium, Cognitive Impairment
Redesigning the Surgical Pathway (PROMoTE)
Cognitive complications, that is problems with thinking and memory, are incredibly common after surgery, occurring in 10-50% of all older surgical patients.
- Conditions
- Delirium, Cognitive Impairment, Perioperative/Postoperative Complications, Cognitive Dysfunction
- Trial name
- PROMoTE (NCT05114876)
- Testing
- Multicomponent delirium-risk prevention bundle
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Sunnybrook Health Sciences Centre
Healthy, Older Adults
Group-Based Exercise Intervention to Prevent Cognitive and Motor Decline
The goal of this clinical trial is to evaluate the efficacy of the Ideomotor Program in healthy older adults living in the community.
- Trial name
- NCT07494149
- Testing
- Ideomotor, Control
- Where
- 2 sites in Italy
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Bergamo
Mild Cognitive Impairment
Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)
Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)
- Trial name
- NCT06347315
- Testing
- BrainXpert
- Where
- 28 sites in France, Germany and 4 more
- Volunteers
- 380 people
- Sponsor
- Société des Produits Nestlé (SPN)
Alzheimer Disease, Down Syndrome
Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study
This study plans to establish a large bank of blood, cerebral spinal fluid (CSF), imaging, and clinical data. These data and samples will be used for future research into the causes of Alzheimer's disease (AD), Down Syndrome (DS)…
- Conditions
- Alzheimer Disease, Down Syndrome, Mild Cognitive Impairment
- Trial name
- NCT02612376
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alzheimer Disease, Dementia
BarcelonaBeta Dementia Prevention Research Clinic: a Study on Risk Factors Disclosure
Alzheimer's disease (AD) is the leading cause of dementia and its prevalence is estimated to exceed 100 million affects by 2050, becoming the main public health problem worldwide.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT03847038
- Testing
- Preventive strategies advice and dementia risk estimate disclosure
- Where
- Spain
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London