Clinical trials: Cognitive Disorder Patients and Cognitive Assessment
Schizophrenia
A Study to Evaluate the Effect of Oral Paliperidone Extended-Release and Oral Risperidone Immediate-Release on Cognitive Function in Clinically Stable Patients With Schizophrenia
The purpose of this study is to compare the effect of oral paliperidone extended-release and oral risperidone immediate-release on cognitive function, especially the category fluency of Cognitive Abilities Screening Instrument…
- Trial name
- NCT01670071
- Testing
- Paliperidone extended-release, Risperidone immediate-release
- Where
- 3 sites in Taiwan
- Volunteers
- 17 people
- Sponsor
- Johnson & Johnson Taiwan Ltd
Alzheimer Disease
A Study of LY3303560 in Participants With Mild Cognitive Impairment or Alzheimer's Disease
The study involves repeated doses of LY3303560 given by infusion for 49 weeks. The study will examine how safe repeated doses of LY3303560 are, whether they cause side effects in participants with mild cognitive impairment or…
- Trial name
- NCT03019536
- Testing
- LY3303560 - IV, Florbetapir F 18, Flortaucipir F18
- Where
- 11 sites in United States, Japan and 1 more
- Volunteers
- 22 people
- Sponsor
- Eli Lilly and Company
MCI, Mild Cognitive Impairment (MCI)
Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards
Cognitive impairment is common among older adults hospitalized for non-neurological conditions but often goes unrecognized, particularly in rehabilitation settings where clinical attention is mainly focused on physical recovery.
- Conditions
- MCI, Mild Cognitive Impairment (MCI), Mild Cognitive Impairment, Cognitive Deficit
- Trial name
- COGinREHAB (NCT07731334)
- Testing
- Cognitive and clinical screening, Extended neuropsychological assessment, Blood biomarker sampling and APOE genotyping
- Where
- 3 sites in Italy
- Volunteers
- 384 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Drepanocytosis, Chronic Neurological Deficiency
Transfusion Exchanges and Cognition in Sickle Cell Disease
DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0).
- Trial name
- DREPA-COG (NCT07168447)
- Where
- 6 sites in France
- Volunteers
- 85 people
- Sponsor
- Centre Hospitalier St Anne
Brain Injuries
Lariboisière Cognitive Assessment: Evaluation of the 1-year Outcomes
Cognitive sequelae are common following acquired brain injuries. However, their detection can be challenging, particularly in acute care units such as neurosurgery.
- Trial name
- ECOG (NCT06171568)
- Testing
- Tests and questionnaires
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
The Effect of Task-Oriented Training in Patients With Multiple Sclerosis
It is reported that 85% of MS patients have gait disturbance, 87.9% balance, 35-90% fatigue and 45-60% cognitive problems. Rehabilitation approaches based on the motor control systems model, the plasticity concept, the motor…
- Trial name
- NCT03505294
- Testing
- Task-oriented training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Gazi University
Cognitive Impairment, Chemobrain
Cognitive Impairment in Treated Breast Cancer Survivors: Possible Approaches
The investigators aim is to conduct a prospective study with three arms, involving non-metastatic breast cancer patients who underwent chemotherapy as part of their treatment and were on a form of hormone therapy at the time of…
- Trial name
- NCT06662474
- Testing
- 1. cognitive stimulation, 2. psychoeducation and cognitive stimulation, 3. no intervention
- Volunteers
- 120 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Cadasil
Efficacy and Safety of Tocotrienols in CADASIL
CADASIL is a paradigmatic cerebral small vessel disease responsible for white-matter lesions, accumulation of lacunes, microbleeds and cerebral atrophy.
- Trial name
- NCT04658823
- Testing
- HOV-12020 (Palm tocotrienols complex)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hovid Berhad
Mild Cognitive Impairment
Support Groups for Patients With Mild Cognitive Impairment and Their Partners
This study aims at developing and evaluating a support group program for patients with mild cognitive impairment (MCI) and their partners. These patients have defective memory function but are not demented.
- Trial name
- NCT00285753
- Testing
- support groups
- Where
- 2 sites in Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Mild Cognitive Impairment, Alzheimer Disease
A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831
This study seeks to evaluate the efficacy and safety of NA-83 in subjects with mild cognitive impairment due to Alzheimer's Disease
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Alzheimer Dementia, Dementia, Vascular
- Trial name
- NCT03538522
- Testing
- N-831(Traneurocin) 10 mg QD, NA-831 (Traneurocin) 20 mg QD, NA-831 (Traneurocin) 40 mg QD
- Where
- 2 sites in New Zealand
- Volunteers
- 126 people
- Sponsor
- Biomed Industries, Inc.
Patent Foramen Ovale
Assessment of Early Vascular Damage With Advanced Neuroimaging in Patient With Patent Foramen Ovale
Patent foramen ovale arises from the incomplete postnatal fusion of the septum primum and secundum and can cause paradoxical embolism in adults.
- Trial name
- NCT04549272
- Testing
- No interventions
- Volunteers
- 100 people
- Sponsor
- Neuromed IRCCS
Mild Cognitive Impairment (MCI), Dementia
Integration of VR and AR Dementia Prevention Health Education Progrom for Older Adults With Mild Cognitive Impairment
The goal of this randomized controlled trial is to evaluate the effectiveness of Virtual Reality (VR)-based cognitive health education for older adults with mild cognitive impairment (MCI) in Taiwan.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Health Literacy, Self-Efficacy
- Trial name
- NCT06888986
- Testing
- VR Dementia Prevention Health Education Module
- Where
- Taiwan
- Volunteers
- 139 people
- Sponsor
- National Taiwan Normal University
Dementia, Cognitive Impairment
Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
In this study, the investigators implement FDG-PET imaging for clients in the Geriatric Psychiatry department at The Royal Ottawa Hospital (ROH) and evaluate the impact of this advanced imaging technique on client care.
- Conditions
- Dementia, Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT05428475
- Testing
- [18F]FDG-PET Scan
- Volunteers
- 15 people
- Sponsor
- Tim Lau
Postoperative Cognitive Dysfunction (POCD), Neurocognitive Function
Target-Controlled Infusion and Postoperative Neurocognitive Outcomes in Geriatric Patients
This prospective observational study aims to evaluate the effects of target-controlled infusion (TCI) on postoperative neurocognitive function in geriatric patients undergoing major non-cardiac surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Neurocognitive Function, Sedation and Analgesia, Geriatric Patients
- Trial name
- TCI-NEURO (NCT07311447)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namigar Turgut
Insomnia Chronic, Insomnia
Assessment of Usability and Preliminary Effectiveness of a Digital Sleep Aid in an Italian Sample
Chronic insomnia affects approximately 30% of the Italian population, leading to significant impairments in daily functioning and overall health.
- Trial name
- REST (NCT06926348)
- Testing
- Digital Health Technology for Chronic Insomnia, Treatment as Usual (TAU)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Universita di Verona
Sepsis
Electroencephalographic Patterns of Septic Patients and Its Correlation With Cognitive Outcomes
The investigators evaluated the electroencephalographic pattern by the Sinek and Young scales during ICU stay and its correlation with cognitive impairment determined by the Montreal Cognitive Assessment (MOCA) in septic patients…
- Trial name
- NCT05448534
- Testing
- Eletroencephalography
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Hospital Sao Domingos
Brain-damaged Patients
IRM Cognition in Patients With Head Trauma
Longitudinal descriptive study of a cohort of twenty brain-damaged patients for a two years period.
- Trial name
- NCT03181373
- Testing
- Cognitive rehabilitation program
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postoperative Cognitive Dysfunction
Evaluation of the Effect of Preoperative Intravenous Amantadine Sulfate on the Postoperative Early Cognitive Functions in a Elderly Patient With Laparoscopic Radical Prostatectomy
Evaluation of the effect of preoperative intravenous administration of amantadine sulfate on the prevention of the development of early cognitive dysfunction in elderly patients undergoing laparoscopic radical prostatectomy
- Trial name
- NCT03988010
- Testing
- Amantadine Sulfate
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- TC Erciyes University
Bipolar Disorder, Bipolar Depression
Functional Assessment of Patients With Acute Bipolar Depression After 8 Months of Follow-up
This study aims to study prospectively for 8 months a sample of bipolar patients with acute depressive episode in order to identify that factors associated with functional impairment, with especial attention to the presence of…
- Trial name
- NCT01255982
- Where
- 24 sites in Spain
- Volunteers
- 249 people
- Sponsor
- AstraZeneca
Virtual Reality, Brain Damage
Evaluation of a Virtual Reality Tool for Identifying the Cognitive Functions of the Right Hemisphere in Patients With Brain Damage -TANGO
Evaluate the diagnostic performance of a virtual reality application to detect the presence of cognitive impairment of the non-dominant hemisphere in patients with brain damage
- Trial name
- TANGO (NCT04288505)
- Testing
- VIRTUAL REALITY application
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Angers