Clinical trials: Cognitive Disorders
Brain Injuries, Traumatic, Confusional State
Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia
The objective of this Phase II trial is to evaluate the feasibility of this study protocol to progress to a large-scale Phase III RCT in the future.
- Conditions
- Brain Injuries, Traumatic, Confusional State, Sensory Motor System Disorder, Alteration of Cognitive Function
- Trial name
- NCT02792985
- Testing
- Multisensory stimulation protocol, Control protocol
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Institut Guttmann
Cognitive Disorders
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-D4010 in Healthy Subjects
The purpose of this study is to investigate the safety, tolerability and pharmacokinetics of SUVN-D4010 in healthy male subjects following single or multiple ascending doses.
- Trial name
- NCT02575482
- Testing
- SUVN-D4010
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suven Life Sciences Limited
Delirium, Inflammation
The Role of Ketamine in Preventing Cognitive Dysfunctions in Postoperative Period of Cardiac Surgery
The purpose of this study is to analyze the Ketamine with its anti-inflammatory profile would be able to prevent cognitive disorders in the postoperative period of cardiac surgery, since these disorders contribute to an impact on…
- Conditions
- Delirium, Inflammation, Cognitive Disorders, Amnestic
- Trial name
- KeCoDy (NCT02782429)
- Testing
- Ketamine, Saline
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Flavia orange
Diabetes, Cancer
Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures
Explore the benefit of the game-based virtual reality system in improving lower extremity kinematics and balance in patients suffering from disease/disorders including Diabetes, Cancer, Multiple Sclerosis, Arthritis, Parkinson's…
- Conditions
- Diabetes, Cancer, Multiple Sclerosis, Arthritis
- Trial name
- NCT02777060
- Testing
- Exergame, Home based balance training
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Alzheimer's Disease
Short Term Efficacy and Safety of Perispinal Administration of Etanercept in Mild to Moderate Alzheimer's Disease
While the cause of AD is still unknown, evidence suggests it develops because of a complex series of events in the brain that occur over time.
- Trial name
- NCT01716637
- Testing
- Etanercept, Curcum.Luteol.Theaflav.Lip.Acid,FishOil,Quercet.,Resveratr.
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Life Extension Foundation Inc.
Multiple Sclerosis, Cognitive Deficits
Computerized Exercise Training for Cognitive Remediation in Adults With Multiple Sclerosis Treated With Gilenya
This study is investigating the efficacy of computer-based cognitive exercises as a means of cognitive remediation in patients with Multiple Sclerosis (MS) who are beginning the disease modifying pharmacotherapy Gileyna.
- Conditions
- Multiple Sclerosis, Cognitive Deficits, Gilenya Modifying Therapy for MS
- Trial name
- NCT02141022
- Testing
- plasticity-based computerized cognitive remediation program, Gileyna
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stony Brook University
Postoperative Cognitive Dysfunction
Cognitive Dysfunction Following Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is the most common complication after cardiac surgery. This prospective study was conducted to investigate the mechanisms of development of POCD following cardiac surgery taking into…
- Trial name
- CDCS (NCT02767713)
- Testing
- Dexamethasone
- Volunteers
- 171 people
- Sponsor
- Clinical Hospital Center, Split
Cognitive Deficit
Deep Brain Stimulation (DBS) of the Nucleus Basalis of Meynert (NbM) in Patients With Parkinson's Disease
The existing DBS setting in patients with DBS of the globus pallidus interna (GPi), which aims to treat motor symptoms by a high-frequency stimulation, will be temporarily reprogramed to stimulate the NbM at a low frequency using…
- Trial name
- NCT02763397
- Testing
- NBM-DBS, DBS
- Volunteers
- 13 people
- Sponsor
- University Medical Center Groningen
Mild Cognitive Impairment (Vascular), Mild Cognitive Disorder (Vascular)
Symptomatic Treatment of Vascular Cognitive Impairment
Single center threeway double blind cross over trial investigating the pharmacological responsivity in patients with VCI using a challenge aimed at the monoaminergic and cholinergic neuronal systems
- Conditions
- Mild Cognitive Impairment (Vascular), Mild Cognitive Disorder (Vascular), Vascular Dementia
- Trial name
- STREAM-VCI (NCT02098824)
- Testing
- Galantamine, Methylphenidate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Amsterdam UMC, location VUmc
Hepatitis C
Cognitive Impairments in Chronic Hepatitis C Patients and Potential Reversibility With New Agents (CICHepC)
The overall aim of this study is to evaluate the prevalence of cognitive impairments and brain anomalies in Chronic Hepatitis C infected individuals and to investigate likely changes in cognition and brain structure and function…
- Trial name
- CICHepC (NCT02745132)
- Testing
- Neuropsychological evaluation and Brain MRI
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Elderly Adults, Parkinson
A Treadmill Training Program Augmented by Virtual Reality to Decrease Fall Risk in Older Adults
The proposed randomized controlled trial will evaluate the effects of treadmill training augmented with virtual reality on fall risk. 300 older adults with a history of falls will be recruited to participate in this study.
- Conditions
- Elderly Adults, Parkinson, Mild Cognitive Disorder
- Trial name
- VTIME (NCT01732653)
- Testing
- TT+VR, TT alone
- Where
- 5 sites in Belgium, Israel and 3 more
- Volunteers
- 302 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Mild Cognitive Impairment, Dementia
Train the Brain - Cognitive and Physical Training for Slowing Dementia
Train The Brain is aimed at assessing the efficacy of cognitive and physical training in slowing progression to dementia in patients diagnosed with mild cognitive impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Dementia, Memory Disorders
- Trial name
- TTB (NCT01725178)
- Testing
- Cognitive and Physical training
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
HIV - Human Immunodeficiency Virus, Cognitive Symptoms
COMO: Cognition Study With HIV+ Patients (CTNPT 015)
The purpose of this study is to contribute evidence towards the potential to improve cognition in HIV+ individuals experiencing cognitive decline through personalized change in antiretroviral (ARV) medication.
- Trial name
- COMO (NCT02144688)
- Testing
- Change in antiretrovirals
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Marie-Josée Brouillette
Cognitive Disorders, Multiple Sclerosis
Evaluation of the Efficiency of a Cognitive Remedial Program (PROCOG-SEP) Designed for Multiple Sclerosis Patients
Cognitive disorders are well-known in multiple sclerosis (MS), even in earlier stages of the disease. They effect personal life. Their management may be overlooked.
- Trial name
- PROCOG-SEP (NCT01659593)
- Testing
- procog
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Central Hospital, Nancy, France
Traumatic Brain Injury, Concussion
Enhancing Cognitive and Neurobehavioral Functions After Repetitive Traumatic Brain Injuries (rTBI) in Retired NFL Players and Military Veterans.
The purpose of this study is to compare different combinations of cognitive training in retired professional football players and military veterans with a history of repeated concussions and persistent symptoms of impaired…
- Conditions
- Traumatic Brain Injury, Concussion, Mild Cognitive Disorder
- Trial name
- NCT02699476
- Testing
- Psycho-Social Therapy, Cognitive Behavioral Computer Training, Interactive Trainer-Subject Sessions
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brain & Body Health Foundation
Alzheimer's Disease, Mild Cognitive Impairment
A Clinical Trial of a Vitamin/Nutriceutical Formulation for Alzheimer's Disease
Based on prior published pilot studies, the investigators have initiated a larger, multi-site placebo-controlled clinical trial with Alzheimer's disease (AD) patients and individuals diagnosed with Mild Cognitive Impairment…
- Trial name
- NCT01320527
- Testing
- Nutriceutical formulation
- Where
- 8 sites in United States
- Volunteers
- 135 people
- Sponsor
- University of Massachusetts, Worcester
Post-Stroke Cognitive Impairment (PSCI)
Efficacy and Safety of Actovegin in Post-stroke Cognitive Impairment (PSCI)
The aim of this trial is to provide evidence that Actovegin has a symptomatic effect in subjects with post stroke cognitive impairment (PSCI) during a six month treatment period compared to subjects administered placebo.
- Trial name
- ARTEMIDA (NCT01582854)
- Testing
- Actovegin
- Where
- 14 sites in Belarus, Kazakhstan and 1 more
- Volunteers
- 503 people
- Sponsor
- Takeda
Major Depressive Disorder, Cognitive Behavior Therapy
Using a Text-message System to Engage Depressed Adolescents in Cognitive-behavioral Therapy Homework
The primary goal of the pilot is to test the feasibility and utility of using a text-messaging system to engage adolescents in improved homework adherence during cognitive-behavioral therapy (CBT) for major depressive disorder.
- Conditions
- Major Depressive Disorder, Cognitive Behavior Therapy, Text Messaging
- Trial name
- NCT00919932
- Testing
- Paper and pen homework, Text message system homework.
- Volunteers
- 9 people
- Sponsor
- University of Pittsburgh
Breast Cancer
Epigenetics and Psychoneurologic Symptoms in Women With Breast Cancer
This study examines the relationship among epigenetic alterations and the development and persistence of psychoneurologic symptoms (cognitive dysfunction, depressive symptoms, anxiety, fatigue, sleep disturbance, and pain) in…
- Trial name
- NCT01411943
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Virginia Commonwealth University
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications
Postoperative Cognitive Dysfunction in Geriatric Patients
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting.
- Conditions
- Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications, Memory Disorders
- Trial name
- NCT00512200
- Where
- Switzerland
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland