Clinical trials: Cognitive Disorders
Distorted; Balance, Motor Deficit
Virtual Reality Based Balance Training in People With Mild Cognitive Impairment
The aim of the present study is to evaluate an innovative virtual reality-based balance training intervention for improving clinically relevant motor performances (balance and gait) in people with mild cognitive impairment.
- Conditions
- Distorted; Balance, Motor Deficit, Cognitive Deficit
- Trial name
- NCT02214342
- Testing
- Balance Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Mild Cognitive Impairment, Major Depressive Disorder
Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment
Alzheimer's disease (AD), the most common dementing disorder of later life, is a major cause of disability and death in the elderly. Although a number of theoretical causes exist, the etiology of AD is still unknown.
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Alzheimer's Disease
- Trial name
- NCT01876823
- Testing
- es-citalopram, Memantine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer's Disease
ADNI: Alzheimer's Disease Neuroimaging Initiative
The purpose of this study is to examine how brain imaging technology can be used with other tests to measure the progression of mild cognitive impairment (MCI) and early Alzheimer's disease (AD).
- Trial name
- NCT00106899
- Testing
- Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Lumbar Puncture (LP)
- Where
- 59 sites in United States, Canada
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Mild Cognitive Impairment, Alzheimer's Disease
Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects With Amnestic Mild Cognitive Impairment Who Will Convert to Clinically Probable Alzheimer's Disease
This study will investigate the efficacy of the Flutemetamol (18F) Injection PET tracer in identifying abnormal (18F) flutemetamol uptake patterns which predict the conversion from aMCI to a b-amyloid associated clinically…
- Trial name
- NCT01028053
- Testing
- Flutemetamol (18F) Injection
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- GE Healthcare
Alzheimer Disease, Dementia
ADVANCE Study: Alzheimer Disease eVAluation iN Clinical PracticE
In 1906, Dr. Alois Alzheimer first described the disease that later took his name. Today, 100 years later, 24 million people worldwide suffer from Alzheimer's disease or other dementias.
- Conditions
- Alzheimer Disease, Dementia, Cognitive Disorders
- Trial name
- ADVANCE (NCT01772095)
- Where
- Greece
- Volunteers
- 389 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Major Depression
Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients
The purpose of this study is to evaluate clinical efficacy (affective and cognitive) in patients with moderate depression between TMS over the left Dorsolateral Prefrontal Cortex (DLPFC) with simulated TMS, as well as clinical…
- Trial name
- NCT02213016
- Testing
- Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Nacional Autonoma de Mexico
Alzheimer's Type Dementia
A Study Versus E2020 10mg Followed by an Open-label Extension Phase to Explore the Safety of E2020 SR 23 mg in Japanese Subjects With Severe Alzheimer's Type Dementia
The purpose of this study is to compare 23 mg donepezil sustained release (SR) to the currently marketed formulation of 10 mg donepezil immediate release (IR) in patients with severe Alzheimer's disease.
- Trial name
- NCT01276353
- Testing
- E2020
- Where
- 11 sites in Japan
- Volunteers
- 45 people
- Sponsor
- Eisai Inc.
Major Depressive Disorder
Efficacy Study of Vortioxetine on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder
Major Depressive Disorder (MDD) is a severe and common psychiatric disorder. Although MDD primarily involves mood disturbances, patients also usually present alterations in cognitive function (attention, memory, executive…
- Trial name
- FOCUS (NCT01422213)
- Testing
- Vortioxetine (Lu AA21004)
- Volunteers
- 598 people
- Sponsor
- H. Lundbeck A/S
Cognitive Dysfunction
Neuropsychological Profile of a Patient's Group With Multiple Sclerosis and Effect of a Cognitive Rehabilitation Program
The purpose of the study is to determine the effect of an web-based intensive cognitive rehabilitation program in neuropsychological performance of a population of patients with multiple sclerosis or clinical isolated syndrome.
- Trial name
- MS_Rehab (NCT02193906)
- Testing
- Cognitive training
- Volunteers
- 75 people
- Sponsor
- Aveiro University
Pain, Retention Disorders, Cognitive
Legacy Intervention Family Enactment (LIFE)
The research activities funded through PAR "Dissemination and Implementation Research in Health" in grant R21NR011112 "Legacy Intervention Family Enactment (LIFE)" have been varied and highly successful.
- Conditions
- Pain, Retention Disorders, Cognitive, Other Chronic Illness, Palliative Care
- Trial name
- LIFE (NCT02007564)
- Testing
- LIFE Intervention
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Alabama, Tuscaloosa
Anxiety, Depression
Brief CBT for Anxiety and Advanced Cancer
RATIONALE: Providing cognitive-behavioral therapy (CBT) may reduce anxiety and improve quality of life of patients with advanced cancer.
- Conditions
- Anxiety, Depression, Unspecified Adult Solid Tumor, Protocol Specific, Cancer
- Trial name
- NCT00706290
- Testing
- Brief Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Massachusetts General Hospital
Age-Related Cognitive Decline, Age-Related Memory Disorders
Memory Improvement With Docosahexaenoic Acid Study (MIDAS)
The purpose of this study is to investigate the effect of docosahexaenoic acid (DHA, 22:6n-3) in improving cognitive functions in subjects with age-related cognitive decline.
- Trial name
- MIDAS (NCT00278135)
- Where
- 14 sites in United States
- Volunteers
- 485 people
- Sponsor
- dsm-firmenich Switzerland AG
Post Low Grade Glioma Surgery, Cognitive Deficits
Hyperbaric Oxygen Therapy Can Improve Cognitive Deficits Post Low Grade Glioma Removal Surgery
The aim of the current study is to evaluate, in a prospective cross-over, randomized study, the effect of hyperbaric oxygen therapy (HBOT) on patients with chronic impairment after low grade glioma tumor removal surgery
- Trial name
- NCT02122042
- Testing
- HBOT
- Where
- Israel
- Volunteers
- 62 people
- Sponsor
- Assaf-Harofeh Medical Center
Bipolar Disorder, Cognitive Impairment
Quetiapine XR for Cognitive and Functional Disability in Clinically Stable Patients With Bipolar Disorder
Quetiapine has been reported to have beneficial cognitive effects in several randomized controlled trials in schizophrenia. It has not yet been studied in bipolar disorder, but promising results from the use of extended release…
- Trial name
- NCT00746421
- Testing
- Quetiapine XR
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Emory University
Memory Disorders, Alzheimer Disease
Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGNISION™) as a Useful Cognitive Biomarker for Alzheimer's Disease.
The proposed study is designed to evaluate the performance of the COGNISION™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Memory Disorders, Alzheimer Disease, Dementia, Cognitive Impairment
- Trial name
- COGNISION™ (NCT00938665)
- Testing
- COGNISION™ System
- Where
- 7 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Neuronetrix, Inc.
Depression, Mental Disorder in Adolescence
Study of Web- Based Cognitive Behavioral Therapy for Depressed Korean Adolescents
The purpose of this study is to develope web-based cognitive behavioral therapy for Korean adoldescents who have a mild depression.
- Conditions
- Depression, Mental Disorder in Adolescence, Cognitive Behavioral Therapy
- Trial name
- wogyeokdajim (NCT02072304)
- Testing
- web-based CBT, supportive care
- Where
- 3 sites in South Korea
- Volunteers
- 164 people
- Sponsor
- Hallym University Medical Center
Executive Dysfunction, Cognitive Deficits
Cognitive Rehabilitation in Patients With Spina Bifida
This study will examine the effects of a theoretically grounded and manualized cognitive rehabilitation program on patients with Spina Bifida (SB).
- Conditions
- Executive Dysfunction, Cognitive Deficits, Spina Bifida
- Trial name
- NCT01302314
- Testing
- Goal management training (GMT)
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Jan Stubberud
Delirium,, Dementia,
Long-term Outcome of General Anesthesia on Dysgnosia
Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed.
- Conditions
- Delirium,, Dementia,, Amnestic,, Cognitive Disorders
- Trial name
- LOGAND (NCT01184638)
- Testing
- Sevoflurane, Propofol
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Nanjing Medical University
Aging, Mild Cognitive Impairment
SMART: Somatotrophics, Memory, and Aging Research Trial
The purpose of the SMART study was to better understand whether the body's own production of growth hormone (GH) would improve memory and problem solving ability, or cognitive function.
- Trial name
- NCT00257712
- Testing
- TH9507 human growth hormone releasing hormone (GHRH)
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cognitive Deficits, Cognitive Ability, General
Childhood Anesthesia and Cognitive Function
The purpose of this study is to determine whether pediatric anesthesia is associated with long-term hippocampal dysfunction
- Trial name
- UCSF-Anes-01 (NCT01359215)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco