Clinical trials: Cognitive Dysfunction, open to volunteers
ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis
ME/CFS Brain Fog: Cognitive Rehabilitation Trial
The purpose of this study is to compare two approaches to cognitive rehabilitation in adults with post-viral cognitive syndrome, which resulted in brain fog.
- Conditions
- ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis, ME/CFS Following COVID-19, Chronic Fatigue
- Trial name
- NCT07523113
- Testing
- Processing Speed Training, In-session Instrumental Activities of Daily Living Training, Transfer Package
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Stroke, Cognitive Decline
Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients: an FNIRS Study
This is an fNIRS study performed to investigate Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients.
- Trial name
- NCT06703320
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dingqun Bai
Dementia With Lewy Bodies, Parkinson Disease Dementia
Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia
The proposed study aims to address the critical gaps in understanding the mechanisms of CF (Cognitive Fluctuations) by leveraging recently emerged molecular biomarkers, advanced neuroimaging techniques to assess measures of…
- Conditions
- Dementia With Lewy Bodies, Parkinson Disease Dementia, Healthy Controls
- Trial name
- NCT07284290
- Testing
- Syn-One skin biopsy, Multi modal MRI, Assessment of dynamic EEG features over 48-hour periods across all study aims
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild
[11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction
Heart failure reduces the amount of blood the heart pumps, which can lead to memory and thinking problems in many patients. One possible reason is that heart failure triggers brain inflammation, a process in which certain brain…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild, Neuroinflammation, Vascular Contributions to Cognitive Impairment and Dementia (VCID)
- Trial name
- NEURO-HF (NCT07856043)
- Testing
- [11C]PS13: [carbon-11]PS13; COX-1 PET radioligand, Sacubitril-Valsartan
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Stony Brook University
Age-related Hearing Loss
Prediction of Age-Related Hearing Loss Based on Comprehensive Risk Factors
This study aims to develop a predictive model for age-related hearing loss (ARHL) based on multi-source risk factors and artificial intelligence techniques.
- Trial name
- NCT07612618
- Testing
- Not applicable- observational study
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
A Clinical Study Evaluating the Diagnostic Performance and Safety of PET for the Deposition of Aβ Plaques in the Brain of Participants With Normal Cognitive Function, MCI and AD Using [18F]Fluorbetazine Injection
A multicenter phase III clinical study evaluating the diagnostic performance and safety of PET for the deposition of Aβ plaques in the brain of participants with normal cognitive function, MCI and AD using [18F]Fluorbetazine…
- Trial name
- NCT07764679
- Testing
- [18F]Fluorbetazine injection
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- HTA Co., Ltd.
Cognitive Dysfunction, Overweight and Obesity
Cognitive Effects of Hesperidin in Overweight/Obese Older Adults
A randomized, double-blind, placebo-controlled trial was designed to test whether two doses of hesperidin (a natural flavonoid from citrus fruits) improve cognitive function in overweight and obese older adults.
- Trial name
- NCT07750223
- Testing
- Hesperidin
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Min Hou
Presbycusis
Hearing and Cognition in Aging Adults
This cohort study is expected to provide valuable insights into the complex interplay between auditory and cognitive functions and how they change over time.
- Trial name
- ACAV (NCT06183450)
- Testing
- auditory level, cognitive level, quality of life level
- Where
- France
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Cognitive Impairment
Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment
This pilot randomized, double-blind, crossover clinical trial will evaluate the effect of a synbiotic containing Lactobacillus acidophilus LA-5 and agave inulin on mild cognitive impairment (MCI) in adults aged 60-75 years…
- Trial name
- NCT07818369
- Testing
- Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin) Intervention Type:
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Anahuac University
Dementia, Mild, Accidental Falls
Development of Pressure Sensor Based Dementia and Fall Prevention Program for Older Adults
The goal of this intervention program is to test the effectiveness of pressure sensor based dementia and fall prevention program for improving cognitive and physical functions of community dwelling older adults.
- Conditions
- Dementia, Mild, Accidental Falls, Mild Cognitive Impairment
- Trial name
- NCT06664229
- Testing
- Fall and dementia prevention exercise
- Where
- South Korea
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Sunmi Song
Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs)
The Signature of Alzheimer's Disease in Subjective Cognitive Decline
This study focuses on improving early detection of Alzheimer's disease (AD) in patients with subjective cognitive decline (SCD), a preclinical stage of cognitive impairment, in the context of emerging disease-modifying therapies…
- Conditions
- Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs), Subjective Cognitive Impairment, Subjective Cognitive Concerns
- Trial name
- SIGN-AL (NCT07402161)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Policlinico S. Donato
Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment
Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative…
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment
- Trial name
- NCT07449117
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- Masaryk University
Mild Cognitive Impairment (MCI)
Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment
This study aims to develop an automated instant message-delivered intervention (i.e., EMI) for people with mild cognitive impairment to reduce their NPS, and to investigate the feasibility and effectiveness of the intervention.
- Trial name
- IMPACT (NCT07420426)
- Testing
- automated instant message-guided neuropsychiatric symptoms management, general mental health management
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Older Adults With Cognitive Decline, Older Adults
Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline
The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living…
- Conditions
- Older Adults With Cognitive Decline, Older Adults, AI-Based Fitness, Wearables
- Trial name
- NCT07207993
- Testing
- Fitness app for self-efficacy, Social network via app for social support, Health education app targeting outcome expectations
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- The University of Tennessee, Knoxville
Rolandic Epilepsy
Music Perception in SeLECTs
Self-limited epilepsy with centrotemporal spikes (SeLECTS) is the most frequent epilepsy syndrome in children between the ages of 4 and 13 years.
- Trial name
- EpiMUS (NCT06545708)
- Testing
- Patients
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
A Pilot Study to Examine the Effect of Egb761 on Plasma Biomarker Levels and on Cognitive Function in Patients With MCI
The goal of this clinical trial is to learn if the drug Egb761, produced from Ginkgo Biloba extract, works to improve the blood level of a biomarker of Alzheimer's disease, called phosphorylated-tau217 (p-tau217), which serves as…
- Trial name
- NCT07287852
- Testing
- Ginkgo Biloba Extract 761
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Alzheimer Disease
F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (DIAN Project)
The purpose of this research study is to evaluate a new radioactive compound used in positron emission tomography (PET) scans in identifying tau tangles (a certain protein that might be associated with Dominantly Inherited…
- Trial name
- AV ADAD (NCT02414178)
- Testing
- F 18 T807
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment, Cerebrovascular Disease
EGb 761 in the Syndrome of MCI With Concomitant CVD
EGb 761 has been demonstrated to be useful in improving cognitive and global clinical outcomes in patients with cognitive impairment or dementia, when administered at a daily dosage of 240mg in randomised controlled trials…
- Trial name
- NCT04525144
- Testing
- Tebonin Forte
- Where
- Singapore
- Volunteers
- 134 people
- Sponsor
- National Neuroscience Institute
Severe Acquired Brain Injury, Cognitive Impairment
Feasibility and Acceptability of StimolIrpinia for Cognitive Rehabilitation After Severe Acquired Brain Injury
This single-center pilot study evaluates the feasibility, acceptability, usability, and preliminary stimulus validation of StimolIrpinia, a multimedia repository of culturally and territorially relevant autobiographical stimuli…
- Conditions
- Severe Acquired Brain Injury, Cognitive Impairment, Cognitive Rehabilitation, Neurorehabilitation
- Trial name
- StimolIrpinia (NCT07718321)
- Testing
- StimolIrpinia-supported cognitive rehabilitation activities
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Alfonso Magliacano
Alzheimer Disease, Mild Cognitive Impairment
MR Elastography of Cognitive Impairment
The purpose of this research is to further investigate the potential of brain stiffness as a novel biomarker for Alzheimer's disease.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Healthy
- Trial name
- NCT06029114
- Testing
- Magnetic Resonance Elastography (MRE)
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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