Clinical trials: Cognitive Dysfunction, open to volunteers
Mild Cognitive Impairment
Improve New Learning and Memory in Individuals With Mild Cognitive Impairment
The current study is a double-blind, placebo-control randomized clinical trial examining the efficacy of memory retraining in individuals with Mild Cognitive Impairment (MCI).
- Trial name
- NCT05396248
- Testing
- Memory Retraining Exercises
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Kessler Foundation
Mild Cognitive Impairment (MCI)
Cognitive-motor Training in Community-dwelling Older People With Mild Cognitive Impairment
As the global population ages, the prevalence of mild cognitive impairment (MCI) among older adults, which ranges from 5% to 40%, is expected to rise.
- Trial name
- NCT07241598
- Testing
- Smart±step cognitive-motor training
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Mahidol University
Physical Activity, Exercise
Goal Setting to Promote Physical Activity Adherence in Midlife Adults
Engaging in regular physical activity during midlife is a key lifestyle behavior associated with reduced risk for Alzheimer's disease and related dementias (AD/ADRD).
- Trial name
- NCT05980052
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Schizophrenia Disorder
Mechanisms of Sulforaphane Supplementation in Alleviating Negative Symptoms and Cognitive Impairment in Schizophrenia
The goal of this randomized, double-blind, placebo-controlled clinical trial with an open-label extension is to evaluate whether sulforaphane can improve negative symptoms and cognitive impairment, and to explore its underlying…
- Trial name
- NCT07652866
- Testing
- Sulforaphane
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Xiangya Hospital of Central South University
Primary Intracerebral Hemorrhage
Biomarkers for Cognitive Decline in Intracerebral Hemorrhage
The goal of this clinical trial is to see if silent brain infarcts (SBIs), or stroke-like symptoms detectable during brain imaging, are a possible contributor to cognitive decline for patients diagnosed with spontaneous…
- Trial name
- NCT06836141
- Testing
- MRI, Blood Draw, Cognitive Test
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Rush University Medical Center
Chronic and Episodic Headache, Headache Disorders
PERSONOLOGICAL STRUCTURE, COGNITIVE FUNCTIONS AND CENTRAL SENSITIZATION IN HEADACHE
Headache, in its episodic and chronic forms, cannot be considered solely as an isolated neurological symptom, but as a complex condition of a bio-psycho-social nature.
- Trial name
- AURA (NCT07268768)
- Testing
- Neuropsychological assessment
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Alzheimer Disease
Multisensory 40-Hz Stimulation for Alzheimer's Disease
This study aims to evaluate the safety and preliminary efficacy of combined auditory and visual 40-Hz stimulation in participants with biomarker-confirmed Alzheimer's disease spectrum disorders.
- Trial name
- NCT07758751
- Testing
- Multisensory 40-Hz Stimulation Device
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Caregiver Stress, Social Isolation in Older Adults
Tech-based Respite Care for Caregivers and Homebound Older Adults
The goal of this study is to examine the effectiveness of VR-based respite in improving cognitive function, mental health, and quality of life in caregivers and homebound older adults compared to a control group using videos and…
- Conditions
- Caregiver Stress, Social Isolation in Older Adults, Cognitive Decline in Older Adults, Depression in Older Adults
- Trial name
- TechRespiteRCT (NCT07160673)
- Testing
- VR-based Respite, Video-based Respite
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- Hong Kong University
Schizophrenia
NMDA-enhancing Treatment for Cognitive Dysfunction of Schizophrenia
Cognitive impairment, the core psychopathology of schizophrenia, usually persists in schizophrenia patients even during symptomatic remission.
- Trial name
- NCT06021197
- Testing
- NMDAE
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Mild Cognitive Impairment (MCI)
The Effects of Single Baduanjin and Elastic Band Exercises on VSWM in Elderly Individuals With MCI
Previous studies have confirmed that both acute (single) and long-term various exercise interventions can significantly improve the cognitive function of individuals with MCI.
- Trial name
- NCT07656480
- Testing
- baduanjin exercise, elastic band exercises
- Volunteers
- 60 people
- Sponsor
- qiu chen
Depressive Disorder, Major, Treatment Outcome
Precision Medicine in the Depression Treatment
The BrainDrugs-D study uses multimodal neuroimaging combined with self-report measures, clinical and molecular markers to identify clinically relevant predictors that can identify subtypes of major depressive disorder (MDD) and…
- Conditions
- Depressive Disorder, Major, Treatment Outcome, Cognitive Dysfunction, Cognitive Behavioral Therapy
- Trial name
- BDD (NCT05616559)
- Testing
- Treatment Package for First-Episode Depression
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Digital Solutions for Predicting the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors
Population ageing is one of the main factors responsible for the global increase in the prevalence of dementia. Recent evidence suggests that modifiable risk factors, such as cardiovascular disease and lifestyle, may increase the…
- Trial name
- PrevAl (NCT07731191)
- Testing
- Digital solution for the prediction of the biological mechanisms of Alzheimer's disease through the analysis of risk factors
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Mild Cognitive Impairment (MCI)
Effect of Inspiratory Muscle Training in Cognition
The goal of this clinical trial is to examine the effect of a respiratory muscle strengthening program on the cognitive and physical functioning of patients with neurocognitive disorders (Mild Cognitive Impairment) or those…
- Trial name
- NCT07146373
- Testing
- Inspiratoty Muscle training, Usual Care
- Where
- Greece
- Volunteers
- 76 people
- Sponsor
- University of West Attica
Cerebrovascular Disorders
Daphnetin Capsule In the Treatment of VaScular COgnitive Impairment Without Dementia
The purpose of this clinical trial is to understand and evaluate the clinical efficacy and safety of Daphnetin Capsule in patients with vascular cognitive impairment.
- Trial name
- DISCO (NCT06507488)
- Testing
- Daphnetin Capsule
- Where
- China
- Volunteers
- 206 people
- Sponsor
- First People's Hospital of Shenyang
Cognitive Dysfunction
The Application of an AI-driven Multimodal Predictive Model for Cognitive Impairment in Patients With Type 2 Diabetes Mellitus
The objective of this observational study is to evaluate the accuracy and feasibility of an artificial intelligence-based multimodal cognitive screening system in early identification of diabetes-related mild cognitive impairment…
- Trial name
- NCT07128186
- Testing
- follow-up observation
- Where
- 21 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Diabetes Mellitus Type 2, Mild Cognitive Impairment
The Early Warning System for the Diabetic Encephalopathy
Diabetes( mainly type II diabetes )lead to the central nervous system (CNS) function impairment, especially the mild cognitive impairment that increased the risk of progression to dementia.The primary objectives are defined…
- Conditions
- Diabetes Mellitus Type 2, Mild Cognitive Impairment, Metabolic Syndrome X
- Trial name
- NCT02420470
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Dementia, Alzheimer Dementia (AD)
Fuzhou Aging Brain Health Initiative
The goal of this observational study is to learn about the pathophysiological characterization and evolutionary patterns of Alzheimer's disease (AD) in older adults in Fujian Province, China.
- Conditions
- Dementia, Alzheimer Dementia (AD), Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- FAITH (NCT07891429)
- Testing
- Fluids biomarker and neuroimaging of AD diagnosis
- Where
- 4 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Immune Thrombotic Thrombocytopenia
Impact of Acute ITTP Therapies on Long Term Neurologic and Cognitive Outcomes in ITTP Survivors
1. We expect to find that the silent cerebral infarct (SCI) rate is two fold higher in patients treated without caplacizumab. We also expect to find that the rate of mild and major cognitive impairment in patients treated with…
- Trial name
- NeST (NCT06358703)
- Testing
- Caplacizumab
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- US Thrombotic Microangiopathy Alliance
Cognitive Disorders
Single-center Prospective Longitudinal Study of Taste in Patients With Cognitive Disorders at Different Stages of Severity (Isolated Cognitive Complaint, Minor or Major Neurocognitive Alzheimer-type Disorders) by Analysis of Gustatory Evoked Potentials
The aim of the MAPEG 2 study is to explore gustatory function and to follow its evolution in the 4 following groups of participants: Healthy subjects Participants with isolated cognitive complaint Participants with minor…
- Trial name
- MAPEG 2 (NCT05888961)
- Testing
- Blood samples, Interviewing the subject and scales, Neurocognitive evaluation
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
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