Clinical trials: Cognitive Dysfunction, open to volunteers
Insomnia, Sleep
Artificial Intelligence (AI)-Assisted Sleep Intervention for Insomnia in Older Adults With Subjective Cognitive Decline
To assess the feasibility and acceptability of Artificial Intelligence (AI)-assisted sleep intervention on improving the insomnia of older adults with subjective cognitive decline.
- Trial name
- NCT07588035
- Testing
- Artificial Intelligence (AI)-assisted sleep intervention, Usual Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
HIE - Hypoxic - Ischemic Encephalopathy, Perinatal Anoxic-ischemic Brain Injury
Biomarkers Study in Infants With Prior Neonatal Brain Injury
This research focuses on the long-term cognitive development of children, including healthy infants and those who had a perinatal brain injury.
- Conditions
- HIE - Hypoxic - Ischemic Encephalopathy, Perinatal Anoxic-ischemic Brain Injury, Premature Birth, Healthy Participants
- Trial name
- NCT07413900
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Mild Cognitive Impairment
EVASION: Effect of VisuAl Stimulation on attentION
The main objective is to compare changes in information processing speed after 30 days of intervention in participants with a dysexecutive mild cognitive impairment (MCI) and receiving either cognitive stimulation by adapted…
- Trial name
- EVASION (NCT05791994)
- Testing
- Visual cognitive stimulation exercises, Broadcast of a television program
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Multimorbidity, Hypertension
Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity
This study aims to test a new comprehensive management service package for older adults with two or more chronic conditions (multimorbidity).
- Conditions
- Multimorbidity, Hypertension, Diabetes Mellitus, Coronary Artery Disease
- Trial name
- COMPASS (NCT07151430)
- Testing
- Service Package Group
- Volunteers
- 358 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer's Disease (AD)
COGSCREEN II: Early Detection of Cognitive Impairment
While knowledge about dementia and its causes is increasing rapidly, healthcare systems remain ill-equipped to detect cognitive decline in the early stages of neurodegenerative diseases such as Alzheimer's disease (AD).
- Trial name
- COGSCREEN II (NCT07466394)
- Testing
- Early Detection
- Where
- Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Robert Perneczky
Tinnitus, Sleep Disturbances
Low-intensity TUS for Sleep Disturbances in Patients With Chronic Tinnitus
Background: Tinnitus, as a common symptom, can jeopardize the sleep quality and brain function and even lead to hearing loss and cognitive decline in elderly patients.
- Conditions
- Tinnitus, Sleep Disturbances, Cognition
- Trial name
- NCT06776705
- Testing
- Low-intensity transcranial ultrasound stimulation
- Where
- 2 sites in Hong Kong
- Volunteers
- 14 people
- Sponsor
- Chinese University of Hong Kong
Cardiac Arrest, Out-Of-Hospital, Cognitive Impairment
Prediction of Delayed Cognitive Impairment in Cardiac Arrest Survivors With Good Neurological Outcomes
The objective of this observational study is to provide basic data for predicting and analyzing the occurrence and causes of delayed cognitive impairment, an important factor in the quality of life, among discharged patients who…
- Trial name
- NCT05830422
- Testing
- nothing
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Chungnam National University Hospital
Mild Cognitive Impairment (MCI)
Non-pharmacological Interventions for People With Mild Cognitive Impairment in the Community
Mild cognitive impairment (MCI) may increase the risk of dementia. This study will evaluate an 8-week community-family mutual support intervention for adults aged 60 years or older with MCI.
- Trial name
- CNPI-MCI (NCT07703267)
- Testing
- Community-Family Mutual Support Intervention, Routine Community Care
- Volunteers
- 70 people
- Sponsor
- Anhui Medical University
Presymptomatic Disease, Mild Cognitive Impairment
Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
The study is carried out as part of the GR2021 Priority project "Healthy Brains for life (Age 20-99): Digitally-enhanced personalized medicine study ANANEOS" and code numbered GR-00546 and it will look at the decentralized and…
- Conditions
- Presymptomatic Disease, Mild Cognitive Impairment, Memory Loss (Excluding Dementia), Cognitive Change
- Trial name
- ANANEOS (NCT04701177)
- Testing
- Teleph0s digital phenotyping platform
- Where
- 4 sites in Greece, Spain
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Greece 2021 Committee
Alzheimer, Cognitive Unimpaired
Brain Heath Service for Prevention of AD
The aim of the program to serve as a prototype for future preventive program for AD in the region. The program will recruit elderly participants.
- Conditions
- Alzheimer, Cognitive Unimpaired, Mild Cognitive Impairment
- Trial name
- BEAT AD (NCT07834528)
- Testing
- medical referral and/or educational programs
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cerebral Small Vessel Diseases
Tongxinluo Capsule in the Treatment of Cerebral Small Vessel Disease-A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study（TOPS-CSVD）
Cerebral small vessel disease is a series of clinical, imaging and pathological syndromes caused by various etiologies affecting the arteries, capillaries, venules in the brain.
- Trial name
- NCT06061692
- Testing
- Tongxinluo Capsule
- Volunteers
- 1,052 people
- Sponsor
- Fudan University
Ischemic Stroke
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline.
- Trial name
- NCT05556395
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Sclerosis, Multiple, Neurocognitive Impairment, Mild
The DANCEREX Proof-of-Concept Study for Chronic Neurological Disorders
The goal of this clinical trial is to test a new digital therapeutic solution which combines a holistic, multidimensional rehabilitation program based on dance and music with an innovative motivational system (DANCEREX-DTx) in…
- Conditions
- Sclerosis, Multiple, Neurocognitive Impairment, Mild, Neurocognitive Dysfunction
- Trial name
- DANCEREX-DTx (NCT06112639)
- Testing
- DANCEREX-DTx, Multidimensional dance-based program, Educational Program
- Where
- 3 sites in Italy
- Volunteers
- 192 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cognitive Impairment
Effects of Aerobic Exercises on Dual-task Performance and Motor Skills in Children With Mild Cognitive Impairment
Cognition refers to the mental processes involved in gaining knowledge and understanding, encompassing aspects such as thinking, knowing, remembering, judging, and problem-solving.
- Trial name
- NCT06867692
- Testing
- Aerobic Exercise, Light Physical Activity Plan
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Biliary Atresia, Cognitive Impairment
BILACO Trial: Biliary Atresia - a Severe Complex Congenital Liver Disease
Biliary atresia is the most severe form of cholestatic liver disease. The children have high morbidity and mortality and get devastating pruritus and fatigue, failure to thrive, progressive hepatic failure and impaired…
- Trial name
- BILACO (NCT05399745)
- Testing
- Neurocognitive monitoring
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Delirium, Postoperative Cognitive Dysfunction
Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients
Elderly patients undergoing transurethral resection are at increased risk of postoperative cognitive dysfunction (POCD) and delirium, which are associated with prolonged hospital stay, increased morbidity, and decreased quality…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Dysfunction
- Trial name
- POCDTURMSTUD (NCT07719712)
- Testing
- Cognitive and Delirium Assessment (MoCA and CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Muğla Sıtkı Koçman University
PARKINSON DISEASE (Disorder), Parkinson
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
Gut problems, such as constipation, can have an important impact on quality of life of people who have them, and have been associated with higher risk of developing neurological diseases such as Parkinson's or Alzheimer's…
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson, Parkinson Disease, Parkinson s Disease
- Trial name
- Met-Pro (NCT07786116)
- Testing
- Probiotic Supplementation with L. reuteri
- Where
- United Kingdom
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Chronic Non-Specific Low Back Pain, Cognitive Decline
The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: A Longitudinal Study
Chronic non-specific low back pain (CNSLBP) is a common condition among older adults and has been associated with an increased risk of executive function impairment.
- Conditions
- Chronic Non-Specific Low Back Pain, Cognitive Decline, Longitudinal Study, Older Adults
- Trial name
- NCT07134699
- Testing
- Participants are not assigned an intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Breast Cancer, Chemo-brain
Assessment of Brain Cognitive Impairment in Breast Cancer
To explore the cognitive impairment caused by chemotherapy and endocrine therapy in premenopausal breast cancer patients and to find biomarkers with early predictive effect on this cognitive impairment by using multimodal…
- Conditions
- Breast Cancer, Chemo-brain, Endocrine Therapy
- Trial name
- NCT05305092
- Testing
- PET/MRI, psychobehavioral tests and questionnaires, serum biomarkers and stool sample
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Insomnia, Cognitive Impairment
RESET-BRAIN: REhabilitation of SleEp and CogniTive Impairment in BReast Cancer Survivors Using an App-based Intervention
The goal of the study is to investigate whether treating insomnia using app-based cognitive behavioral therapy for insomnia (CBT-I) can improve cognitive impairment in breast cancer survivors compared to an active control group…
- Conditions
- Insomnia, Cognitive Impairment, Breast Cancer
- Trial name
- RESET-BRAIN (NCT06553235)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep hygiene education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Aarhus University Hospital
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