Clinical trials: Cognitive Dysfunction, open to volunteers
Cognitive Impairment, Dementia
Hainan Community Cognition Cohort
This is a community-based prospective cohort study in Hainan Province, China. The study was initialized in 2023 and included older residents for longitudinal follow-up.
- Conditions
- Cognitive Impairment, Dementia, Age Problems
- Trial name
- NCT06686186
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Hainan Medical College
Alzheimer Disease, Mild Cognitive Impairment
ADRC Clinical Cohort (Alzheimer's Disease)
The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06703541
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Duke University
Alzheimer Disease, Cognitive Impairment
Clinical Evaluation on the Therapeutic Effect of Acupuncture Treatment for Alzheimer's Disease
The objective of this proposed study is to evaluate the effect and safety of acupuncture combined therapy on cognitive function, daily living ability and quality of life of Alzheimer's disease by using the international dementia…
- Trial name
- NCT03810794
- Testing
- Acupuncture, Donepezil
- Where
- 3 sites in China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jian Pei,MD
Parkinson Disease
Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease
This is a pilot randomized, sham-controlled, double-blind, multi-center study evaluating the safety and preliminary effectiveness of the Gen0Bh Transcranial Focused Ultrasound System for the treatment of motor symptoms in…
- Trial name
- NCT07207122
- Testing
- Gen0Bh Transcranial Focused Ultrasound System (Active)
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Sanmai Technologies PBC dba Sanmai
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
Effectiveness of Genistein in Mild Cognitive Impairment
Randomized, placebo-controlled, double-blind, multicenter clinical trial with two parallel study arms (experimental and placebo) to assess the efficacy of genistein extract consumption over 18 months on cognitive decline in…
- Trial name
- EXTRAGENIAL (NCT07385937)
- Testing
- Genistein
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Peripheral Arterial Disease, Critical Limb Ischemia
Leg Ischaemia Management Collaboration
Single-centre prospective cohort study of patients presenting with severe limb ischaemia (SLI). The primary outcome measure will be 12 month major amputation rate.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Frailty, Cognitive Impairment
- Trial name
- LIMb (NCT04027244)
- Where
- United Kingdom
- Volunteers
- 420 people
- Sponsor
- University of Leicester
Minor Stroke
Early-phase Telecare Programs for Minor Stroke
Minor strokes (few acute neurological symptoms ; NIHSS score <5), represent almost 65% of cerebrovascular ischemic events. The increasing incidence of stroke in people under 65, together with advances in diagnostic and…
- Trial name
- COGaDOM (NCT06306144)
- Testing
- Psychoeducation, Computerised Cognitive Stimulation, Usual Care
- Where
- 3 sites in France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
Virtual Reality for Recovery After Intensive Care (PICS)
The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU).
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Rehabilitation After Critical Illness, Rehabilitation Exercise of ICU Patients
- Trial name
- VR4ICU (NCT07585500)
- Testing
- Immersive VR Multi-Domain Rehabilitation, Tablet-Based Multi-Domain Training
- Where
- Portugal
- Volunteers
- 51 people
- Sponsor
- University of Minho
Alzheimer Disease, Mild Cognitive Impairment
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Logopenic Progressive Aphasia, Amnestic Symptoms
- Trial name
- NCT06538311
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Alzheimer Disease, Early Onset
Transcranial Magnetic Stimulation to Slow Down Cognitive Decline in Alzheimer's Disease
New amyloid-targeting drugs for Alzheimer's disease (AD) offer minimal or unclear efficacy and often cause adverse events, highlighting the need for new therapies.
- Trial name
- TMSLA (NCT07036328)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Willem de Haan
Telerehabilitation, Multiple Sclerosis
Cognitive Rehabilitation of Deficits in Patients With Multiple Sclerosis
Non-Inferiority Study, Post-Market Clinical Investigation with a Device, Single-Blind Randomized Controlled Trial in a Cohort of Patients Diagnosed with Multiple Sclerosis (MS).
- Conditions
- Telerehabilitation, Multiple Sclerosis, Cognitive Disorders, Neurorehabilitation
- Trial name
- NCT06964581
- Testing
- Cognitive treatment delivered via telerehabilitation., In-person cognitive treatment.
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Universita di Verona
Parkinson Disease, Cognitive Deficit in Attention
The Effect of Different Types of Focus Instructions in Parkinson's Rehabilitation
Parkinson's disease is the most common progressive neurodegenerative movement disorder. Common movement impairments in Parkinson's include balance and walking difficulties.
- Conditions
- Parkinson Disease, Cognitive Deficit in Attention, Feedback, Psychological, Gait, Festinating
- Trial name
- NCT06615115
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Mild Cognitive Impairment, Depression
Transcranial Magnetic Stimulation for MCI
The goal of this phase II study is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (accelerated Transcranial Magnetic Stimulation (TMS)) to improve both depression…
- Trial name
- PUSH2 (NCT05992831)
- Testing
- Accelerated iTBS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Alzheimer Disease
Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
This study is a prospective, single-center, single-arm early feasibility study, to establish safety and tolerability of LIFU for neuromodulation in patients with mild cognitive impairment ( MCI) due to Alzheimer's disease.
- Trial name
- NCT05997030
- Testing
- low intensity focused ultrasound (LIFU)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ali Rezai
Cancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction
CanCOG®: Pilot Trial of Cognitive Rehabilitation for Cancer Survivors
Cancer-related cognitive impairment (CRCI) affects a large proportion of non-central nervous system cancer survivors and can negatively impact cognitive functioning and daily life.
- Conditions
- Cancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction, Cancer-related Cognitive Difficulties, Depression and Anxiety Symptoms
- Trial name
- CanCOG® (NCT07755839)
- Testing
- CanCOG® - Cogntive Rehabilitation in Cancer
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Aveiro University
Alzheimer Disease, Mild Cognitive Impairment
The COMFORTage Project at Ace Alzheimer Center Barcelona
The COMFORTage study at Ace Alzheimer Center Barcelona is investigating whether a personalized cognitive and functional stimulation program can help slow cognitive decline in individuals diagnosed with mild cognitive impairment…
- Trial name
- COMFORTage (NCT07031167)
- Testing
- Cognitive and functional stimulation using digital platforms
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació ACE Institut Català de Neurociències Aplicades
Aging, Cognitive Impairment
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
The aim of this study is to design a sleep and mindfulness intervention to improve sleep, quality of life, and cognitive function among older adults.
- Conditions
- Aging, Cognitive Impairment, Sleep
- Trial name
- NCT06989619
- Testing
- Sleep health and mindfulness intervention
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 2, Heart Failure
Prediction of Heart Failure and Cognitive Decline in Type 2 Diabetes
Type 2 diabetes is a risk factor of heart failure and cognitive decline. Heart failure at its early stage is often silent. At present, primary prevention for heart failure is not available.
- Conditions
- Diabetes Mellitus, Type 2, Heart Failure, Cognitive Decline
- Trial name
- PreciDIAB-H&B (NCT04583800)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Lille
Cognitive Decline, Hypertension
MIND Foods and Aerobic Training in Black Adults With HTN
The goal of this randomized controlled trial is to determine the impact of Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diet and aerobic training on cognition in Black adults with high systolic blood…
- Conditions
- Cognitive Decline, Hypertension, Diet, Aerobic Exercise
- Trial name
- MAT (NCT06152614)
- Testing
- Enhanced Usual Care (EUC), Food Delivery and Cooking PLUS Aerobic Training (FoRKS+)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Indiana University
Atrial Fibrillation
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
The DaRe2 approach (healthcare Data for pragmatic clinical Research in the NHS - primary 2 secondary) is designed to operationalise efficient, nationwide, primary care approaches for randomised trials embedded within the UK…
- Trial name
- DaRe2THINK (NCT04700826)
- Testing
- Direct Oral Anticoagulants
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University of Birmingham
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