Clinical trials: Cognitive Dysfunction, open to volunteers
Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment and Psychopathology
Mild Cognitive Impairment (MCI) is a condition characterized by cognitive deterioration greater than what is expected from normal aging, representing an important risk factor for the development of dementia.
- Trial name
- MIND (NCT07358962)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Acute Kidney Injury
Application of CLCVP Technique in Early Intervention of CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT05855954
- Testing
- controlled low central venous pressure technique (CLCVP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Alzheimer Disease, Cognitive Impairment
Clinical Evaluation on the Therapeutic Effect of Acupuncture Treatment for Alzheimer's Disease
The objective of this proposed study is to evaluate the effect and safety of acupuncture combined therapy on cognitive function, daily living ability and quality of life of Alzheimer's disease by using the international dementia…
- Trial name
- NCT03810794
- Testing
- Acupuncture, Donepezil
- Where
- 3 sites in China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Jian Pei,MD
Cognitive Impairment, High Fall Risk
Fall Prevention in Mild Cognitive Impairment
Falls represent the leading cause of hospitalization, nursing home admissions, disability and mortality for older adults with annual healthcare costs over $50 billion.
- Trial name
- NEUROFALL (NCT07507812)
- Testing
- Virtual Neurophysiological Rehabilitation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Disorder
Study on the Effect of Online Cognitive Training Doses on Cognitive Function in Individuals With Mild Cognitive Decline
The primary questions that this clinical trial aims to answer are: To compare the differences in the efficacy of different doses of Computerized Cognitive Training (CCT) in improving cognitive function among patients with Mild…
- Trial name
- NCT07213362
- Testing
- Computerized Cognitive Training
- Volunteers
- 234 people
- Sponsor
- Peking University
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Mild Cognitive Impairment
Assessing and Improving the Durability of Compensatory Cognitive Training for Older Veterans
Veterans have numerous risk factors (e.g., Post-traumatic stress disorder (PTSD), traumatic brain injury (TBI), cerebrovascular problems) for later-life cognitive and functional decline.
- Trial name
- AID-CCT (NCT05770479)
- Testing
- Motivationally-Enhanced Compensatory Cognitive Training (ME-CCT) Booster Modules, Treatment As Usual
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Severe Acute Malnutrition, Cognitive Impairment
Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition
The goal of this clinical trial is to test the use of milk fat globule membrane (MFGM) in ready-to-use therapeutic food (RUTF) in children with severe acute malnutrition in Sierra Leone.
- Conditions
- Severe Acute Malnutrition, Cognitive Impairment, Kwashiorkor, Severe Wasting
- Trial name
- MEND-SAM (NCT06869850)
- Testing
- MFGM-RUTF (milk fat globule membrane ready-to-use therapeutic food), S-RUTF (standard ready-to-use therapeutic food), Amoxicillin
- Where
- 10 sites in Sierra Leone
- Volunteers
- 1,600 people
- Sponsor
- Washington University School of Medicine
Alzheimer Disease, Mild Alzheimer Disease
Repurposing Siponimod for Alzheimer's Disease
Collaboration with multiple sclerosis (MS) specialty colleagues led us to formulate the central hypothesis that Siponimod could lower the rate of brain atrophy in Alzheimer's disease (AD) subjects.
- Conditions
- Alzheimer Disease, Mild Alzheimer Disease, MCI With Increased Risk for Alzheimer Disease, Cognitive Impairment, Mild
- Trial name
- SIPO1-AD (NCT06639282)
- Testing
- Siponimod
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Parkinson Disease, Mild Cognitive Impairment
Financial Abilities in Neurological Diseases. Development of a Telerehabilitation Program: FINAGE
Financial Abilities (FA) are a set of capacities that allow a person to independently manage her/his financial affairs in a manner consistent with personal self-interests and values.
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Stroke
- Trial name
- FINAGE (NCT05826548)
- Testing
- Telerehabilitation group, Conventioanl treatment group
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Mild Cognitive Impairment, Mild Dementia
Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease
This study is a multicentre, randomized, double-blind, controlled trial that aims to investigate the efficacy of multi-domain life-style intervention including low inflammatory-index diet, exercise, and cognitive training in…
- Trial name
- SIM-2 (NCT05887674)
- Testing
- Diet intervention, Exercise, Cognitive training
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruijin Hospital
Medulloblastoma, Childhood, Cognitive Impairment
Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in children/adolescents treated for a brain tumour will be investigated in a multi-site Phase III randomized double-blind…
- Trial name
- Met Med Can (NCT05230758)
- Testing
- Metformin hydrochloride (HCl) 500mg tablet
- Where
- 20 sites in Australia, Canada
- Volunteers
- 140 people
- Sponsor
- Donald Mabbott
Mild Cognitive Impairment
Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment
This study will investigate the feasibility of implementing a time-restricted eating intervention in females with mild cognitive impairment.
- Trial name
- NCT05858008
- Testing
- Time-restricted eating
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Julie Pendergast
Alzheimer Disease
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
The primary purpose of this study is to evaluate the safety and tolerability of Zunveyl® over 12 weeks of routine clinical use in adults with mild to moderate Alzheimer's disease.
- Trial name
- RESOLVE (NCT07633470)
- Testing
- Zunveyl®
- Where
- 22 sites in United States
- Volunteers
- 150 people
- Sponsor
- Alpha Cognition, Inc
Ageing, Disability
The Beijing Longitudinal Disability Survey in Community Elderly
The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for…
- Conditions
- Ageing, Disability, Cognitive Impairment, Frailty
- Trial name
- BLINDSCE (NCT06863727)
- Where
- China
- Volunteers
- 1,962 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Cerebrovascular Disorders
Daphnetin Capsule In the Treatment of VaScular COgnitive Impairment Without Dementia
The purpose of this clinical trial is to understand and evaluate the clinical efficacy and safety of Daphnetin Capsule in patients with vascular cognitive impairment.
- Trial name
- DISCO (NCT06507488)
- Testing
- Daphnetin Capsule
- Where
- China
- Volunteers
- 206 people
- Sponsor
- First People's Hospital of Shenyang
Parkinson's Disease, Mild Cognitive Impairment
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor…
- Trial name
- NCT05968703
- Testing
- Combined STN+NBM DBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Helen M. Bronte-Stewart
Frailty, Cognitive Dysfunction
Trajectory of Frailty and Cognitive Dysfunction in Older Adults
To explore the heterogeneity of the development trend of frailty and cognitive function of older adults.
- Conditions
- Frailty, Cognitive Dysfunction, Community-dwelling Older Adults
- Trial name
- NCT06276166
- Testing
- No intervention
- Volunteers
- 934 people, healthy volunteers welcome
- Sponsor
- Zheng Li
Postoperative Delirium, Postoperative Cognitive Dysfunction
Bilateral Bispectral Index, Asymmetries and Post-operative Delirium
The primary objective of the study is to describe the value of interhemispheric asymmetry (ASYM), during the different intra- and peri-operative phases, in those patients who develop or do not develop post-operative delirium…
- Trial name
- DELBIS (NCT06761573)
- Testing
- Bilateral Bispetral Index Monitor will be applied on forehead of our patients, before surgery begins
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna