Clinical trials: Cognitive Dysfunction, open to volunteers
Stroke
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these…
- Trial name
- PROTECT (NCT07445841)
- Testing
- Multimodal Training, Balance, Toning and Stretching
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McGill University
Cancer-related Cognitive Impairment
Photobiomodulation for Cancer-Related Cognitive Impairment
This is a single site, pilot randomized, double blinded control trial designed to assess changes in cognitive symptoms in cancer survivors with cancer-related cognitive impairment.
- Trial name
- NCT05855694
- Testing
- THOR LED Photobiomodulation Helmet - Therapeutic, THOR LED Photobiomodulation Helmet - Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arash Asher, MD
Dementia, Parkinsonism
DaTSCAN Imaging in Aging and Neurodegenerative Disease
The investigators propose using DaTscan in patients with REM sleep behavior disorder (RBD), mild cognitive impairment (MCI), Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and other…
- Conditions
- Dementia, Parkinsonism, Mild Cognitive Impairment, REM Sleep Behavior Disorder
- Trial name
- NCT01453127
- Testing
- I-123 Ioflupane solution injection prior to SPECT scan (DaTscan), Single photon emission computed tomography (SPECT) scan
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Cognitive Dysfunction, Memory Disorders
A Study of Retinal Imaging to Detect Abnormal Protein Deposits Associated With Alzheimer's Disease
The purpose of this study is to test the use of a screening tool to detect changes in the eye that are associated with Alzheimer's disease in adult participants with memory issues.
- Trial name
- NCT07254234
- Testing
- Retinal scan, Blood test
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- Eli Lilly and Company
Negative Symptoms in Schizophrenia, Cognition Function
tACS to Improve Negative Symptoms & Cognition in Long-term Hospitalized Schizophrenia Patients.
This study aims to evaluate the efficacy of transcranial alternating current stimulation (tACS) on negative symptoms and cognitive function in long-term hospitalized patients with schizophrenia.
- Trial name
- NCT07074704
- Testing
- Hi-tACS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tongji University
Neurodegenerative Disease, Dementia
Cognition and Affective Research in China
This is a prospective cohort study of patients with cognitive impairment mood disorders and behavioral disorders. Comprehensive baseline and longitudinal follow-up assessments include clinical and epidemiological data, cognitive…
- Conditions
- Neurodegenerative Disease, Dementia, Alzheimer's Disease, Parkinson's Disease
- Trial name
- CARE (NCT07833267)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Mild Cognitive Impairment
Five Lives MED to Improve Cognitive Function in Mild Cognitive Impairment
The goal of this randomized controlled trial is to determine whether the digital health app Five Lives MED can improve cognitive function in people with mild cognitive impairment (MCI).
- Trial name
- NCT06598163
- Testing
- Five Lives MED
- Where
- 7 sites in France, United Kingdom
- Volunteers
- 170 people
- Sponsor
- SharpTx
Obstructive Sleep Apnea
Brain Fog in Sleep Apnea
Objective: This observational, cross-sectional pilot study aims to assess "Brain Fog" (cognitive symptoms impacting memory, attention, and concentration) in severe Obstructive Sleep Apnea (OSA) patients.
- Trial name
- BF -OSA (NCT06664450)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Obstructive Sleep Apnea, Cognitive Decline
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from…
- Trial name
- ESSENTIAL (NCT05988385)
- Testing
- Positive airway pressure, Oral appliance therapy, Positional therapy
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- California Pacific Medical Center Research Institute
Mild Cognitive Impairment, Alzheimer Disease
Understanding Brain Mechanisms Involved in Autobiographical Memory
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Loss
- Trial name
- NCT05710549
- Testing
- high-density electroencephalography (hdEEG), Transcranial alternating current stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention and Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- Quest-Tablet (NCT05625425)
- Testing
- LabyrinthVR software, Labyrinth Tablet software, Labyrinth VR wireless
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Vascular Cognitive Impairment, Mild Cognitive Impairment
Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory.
- Trial name
- EXPRESS-V (NCT05079464)
- Testing
- tDCS, Exercise, Treatment as usual
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Sunnybrook Health Sciences Centre
Stroke, Ischemic, Sleep Disorder
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients.
- Trial name
- NCT05242393
- Testing
- No intervention is planned
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Postoperative Delirium, Major Noncardiac Surgery
The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality.
- Conditions
- Postoperative Delirium, Major Noncardiac Surgery, Postoperative Cognitive Dysfunction
- Trial name
- RAPID-II (NCT05990790)
- Testing
- Desflurane, Sevoflurane, Propofol
- Where
- 2 sites in Austria
- Volunteers
- 1,332 people
- Sponsor
- Medical University of Vienna
Alzheimer's Disease (AD), Mild Cognitive Impairment Due to Alzheimer's Disease
An Evaluation of Treatments for Sustained Clinical Response (18 Months) in Symptomatic Alzheimer's Disease
A multicentre, interventional, multi-arm, multi-stage Phase 3 trial including randomisation, double blinding, placebo control evaluation of treatments for sustained clinical response (18 months) in symptomatic Alzheimer's Disease…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer Disease Dementia
- Trial name
- AD-SMART (NCT07724132)
- Testing
- Atomoxetine, Metformin 1000 mg Oral Tablet
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- University College, London
Ischemia; Cerebrovascular, Cognitive Impairment
LA Improves the Prognosis of Patients With ICVD After Surgery
Ischemic cerebrovascular disease will cause serious harm to the life and safety of patients, and the treatment prognosis is poor.
- Trial name
- NCT05656209
- Testing
- Lactobacillus acidophilus
- Volunteers
- 236 people
- Sponsor
- Huaqiu Zhang
Insomnia, Sleep
Artificial Intelligence (AI)-Assisted Sleep Intervention for Insomnia in Older Adults With Subjective Cognitive Decline
To assess the feasibility and acceptability of Artificial Intelligence (AI)-assisted sleep intervention on improving the insomnia of older adults with subjective cognitive decline.
- Trial name
- NCT07588035
- Testing
- Artificial Intelligence (AI)-assisted sleep intervention, Usual Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Post-stroke Cognitive Impairment (PSCI)
Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)
Post-stroke cognitive impairment (PSCI) refers to a clinical syndrome characterized by cognitive impairment that occurs after a stroke event and persists for at least 24 weeks.
- Trial name
- Be-CLEVER (NCT05976152)
- Testing
- dl-3-butylphthalide
- Where
- China
- Volunteers
- 3,200 people
- Sponsor
- Fudan University
Mild Cognitive Impairment
Personalized Medicine in the Elderly With Vision Impairment and Mild Cognitive Impairment
Globally, approximately 55 million people suffer from dementia, and 60-70% of cases are due to Alzheimer's disease (AD). Increasing scientific evidence highlights that the pathological changes underlying AD and other forms of…
- Trial name
- Eye-MCI (NCT06942728)
- Testing
- nLIFE EyeFitness
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Patients With Cancer
Cognition Assessment and REhabilitation in Virtual Reality for Patients With Cancer
1. To assess the cognitive function of patients with cancer by leveraging a validated virtual reality (VR)-based cognitive assessment tool. 2.
- Trial name
- CARE-VR4PC (NCT07335393)
- Testing
- VR-based cognitive rehabilitation therapy (VR-CRT)
- Volunteers
- 64 people
- Sponsor
- JING MINGXUE
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