Clinical trials: Cognitive Enhancement
Epilepsy
fMRI Guided TMS Enhancement of Associative Memory Networks
This is a randomized, single-blinded, controlled phase 1 study to demonstrate feasibility and explore the neurophysiologic and clinical effects of repetitive transcranial magnetic stimulation (TMS) interventions in epilepsy…
- Trial name
- NCT02749422
- Testing
- MagStim RapidStim2
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Edentulism Complete, Denture, Complete
Nutritional Intervention for Older Adults With Complete Dentures
The purpose of this clinical trial is to test a nutritional intervention. This study helps older adults who wear complete removable dentures improve their health.
- Conditions
- Edentulism Complete, Denture, Complete, Mastication Disorder
- Trial name
- NCT07692828
- Testing
- Nutritional Intervention
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Universidad de La Frontera
Stress, Mindfulness
Enhanced Stress Resilience Training for Residents
Burnout and overwhelming stress are growing issues in medicine and are associated with mental illness, performance deficits and diminished patient care.
- Conditions
- Stress, Mindfulness, Cognitive Change
- Trial name
- ESRT-R (NCT03518359)
- Testing
- Enhanced Stress Resilience Training (ESRT), Active Control
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Down Syndrome, Mild Cognitive Impairment
Nicotine Treatment of Cognitive Decline in Down Syndrome
This study will ascertain whether nicotine is safe and tolerable in DS patients, help with dose-ranging of nicotine in DS, look for evidence of enhancements in cognitive functioning, and establish evidence for biological and…
- Trial name
- NCT01778946
- Testing
- Low Dose Nicotine (7mg), Moderate Dose Nicotine (14mg)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Breast Cancer
The Effect of Acupuncture on Cancer-Related Cognitive Difficulties
The purpose of this study is to test whether acupuncture can improve cognitive difficulties and insomnia in survivors of breast cancer.
- Trial name
- NCT04837820
- Testing
- Acupuncture, Wait-List Control (WLC), Questionnaires
- Where
- 7 sites in United States
- Volunteers
- 270 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Inflammatory Bowel Diseases
Heart Rate Variability and Inflammatory Bowel Disease
The goals of this study are to test the effectiveness of a virtually delivered, group-based coping skills treatment program incorporating heart rate variability biofeedback to target autonomic dysfunction in youth diagnosed with…
- Trial name
- NCT06537258
- Testing
- Biofeedback Enhanced Treatment
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- Emory University
Mindfulness, Alzheimer's Disease Related Dementia
Mindfulness to Enhance Cognitive Health in Latino Older Adults
The primary objective of the proposed research is to investigate the promise and underlying mechanisms of mindfulness training as a preventative lifestyle intervention to enhance cognitive health in Latino older adults, thereby…
- Trial name
- MLX (NCT07040904)
- Testing
- mindfulness
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Type 1 Diabetes
Effects of Acute Intake of Caffeinated Beverages in Type 1 Diabetes
The aim of this pilot study is to determine the impact of caffeine-enhanced energy drinks on blood glucose excursion on heart rate, blood pressure, cardiac output and cognitive performance in patients with type 1 diabetes.
- Trial name
- REDBULL (NCT01805700)
- Testing
- Caffeine enhanced energy drink, Glucose drink
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- The Royal Bournemouth Hospital
Aging
Activities for Cognitive Enhancement of Seniors
Cognitive aging and cognitive decline are important public health concerns in an aging US population. The investigators will conduct a randomized controlled trail among healthy older adults to assess effects of several innovative…
- Trial name
- ACE-Seniors (NCT01094509)
- Testing
- Tai Chi, Guided autobiography, Qigong
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
Reaction Time, Alertness
tFUS to Enhance Alertness and Performance
The investigators goal is to target FUS energy to the centromedian nucleus of the thalamus (CMT), the core of arousal, which is inaccessible by traditional non-invasive neuromodulation devices.
- Trial name
- NCT06461221
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Aging
Cognitive Enhancement and Risk-reduction Through Exercise for Brain-Related Outcomes
As the population ages, it is also growing more diverse. Twelve percent of older Latinos are currently diagnosed with Alzheimer's disease (AD), and it is estimated that the number of Latinos with AD will increase by 832% by 2060.
- Trial name
- CEREBRO (NCT05588778)
- Testing
- BAILAMOS™ @home/en casa, ¡En Forma y Fuerte! @home/en casa
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Healthy, Cognition
Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity
This study examined whether standardized IQ test scores in healthy adults aged 18-35 are stable measures of cognitive ability and evaluated whether standardized cognitive-test performance and response-initiation measures vary…
- Conditions
- Healthy, Cognition, Sleep Deprivation
- Trial name
- NCT07852130
- Testing
- Modafinil, Oxiracetam, Pramiracetam
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Abdulraheem Mohamed Gouda
Alzheimer's Disease
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Background: Normal aging, as well as dementias such as Alzheimer s disease, can cause changes in the brain that affect memory, attention, and thinking.
- Trial name
- NCT07721467
- Testing
- Psilocybin, Cognitive Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Aging
Computer-Based Training for Cognitive Enhancement: Classroom Study
The primary objective of this study is to evaluate the design and effectiveness of a computer-based training program on the memory and cognitive abilities of mature individuals undergoing healthy aging.
- Trial name
- NCT00337909
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Educational DVDs
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Gamma Oscillations, Healthy Adults
Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement
This study aims to evaluate whether personalized gamma-frequency auditory stimulation enhances cognitive function and brain synchronization.
- Conditions
- Gamma Oscillations, Healthy Adults, Alzheimer's Disease (AD), Gamma Entrainment Using Sensory Stimuli (GENUS)
- Trial name
- NCT07690865
- Testing
- Personalized optimal gamma auditory frequency stimulation, Non-optimal gamma auditory frequency stimulation
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Traumatic Brain Injury, Depression
Feasibility Study of Duloxetine in the Treatment of Depression in Patients With Traumatic Brain Injury
The primary objective of the study is to compare the efficacy of duloxetine 60 mg by mouth daily with placebo in the prevention of depression associated with mild/moderate traumatic brain injury and to enhance cognitive function.
- Trial name
- Duloxetine (NCT01223001)
- Testing
- Duloxetine, Sugar pill
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rehabilitation Hospital of Indiana
Emotion Regulation, Mood Disorders
Neurostimulation Versus Therapy for Problems With Emotions
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation…
- Conditions
- Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders
- Trial name
- NCT05712057
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), electrical scalp stimulation, Cognitive Restructuring
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Duke University
Alzheimer Disease, Dementia
Neurostimulation for Cognitive Enhancement in Alzheimer's Disease
The prevalence of Alzheimer's Disease (AD) is rising, but existing medications provide only modest control of cognitive decline and associated symptoms, and novel therapies are urgently needed.
- Trial name
- NICE-AD (NCT04404153)
- Testing
- tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver active tDCS.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albert Einstein College of Medicine
Pathological Gambling
A Pilot SMART Design for Pathological Gamblers
Pathological gambling is serious problem, with significant psychological, financial, and public health consequences. Nevertheless, controlled trials examining the efficacy of therapeutic interventions for pathological gamblers…
- Trial name
- SMART (NCT00685724)
- Testing
- Motivational Enhancement Therapy (MET), Cognitive-Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- UConn Health
Mild Cognitive Impairment, Subjective Cognitive Decline
Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline
The goal of this clinical trial]is to evaluate if learning to play traditional board games could improve cognition in subjects with mild cognitive impairment and subjective cognitive decline.
- Trial name
- Cognichess (NCT06281652)
- Testing
- Go classes, Chess classes
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Milano Bicocca