Clinical trials: Cognitive Fatigue
- Condition Cognitive Fatigue
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Mental Energy, Physical Performance
Dose Effect of a Plant Extract on Fatigue
Test the short-term effects of the acute consumption of two separate beverages containing different concentrations of polyphenols, a beverage containing 75 mg of caffeine and a flavored placebo beverage on mental energy and…
- Trial name
- NCT03870126
- Testing
- Flavored beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Fatigue, Mental, Alertness
Effect of Coffeeberry on Mood, Motivation and Cognitive Performance
The primary purpose is to test the short-term effects of the acute consumption of two novel beverages made from coffeeberries, the fruit of the coffee plant (Coffea arabica) benchmarked against caffeine on several aspects of…
- Conditions
- Fatigue, Mental, Alertness, Mood, Motivation
- Trial name
- NCT04974606
- Testing
- Cherry-flavored still beverage
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Aging, Cognitive Decline
Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes
This is a parallel group, randomized, double-blind, placebo-controlled clinical study assessing the safety and effects of a novel nutritional product on self-reported cognitive function and health in adults that reside in the…
- Conditions
- Aging, Cognitive Decline, Brain Fog, Cognitive Function
- Trial name
- CLARITY (NCT07060898)
- Testing
- Active Product
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Change in Cognitive Function and Fatigue During Extended Performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 Hours Post Consumption, Change in Long Term Declarative Memory at 1, 3 and 6 Hours Post-intervention.
Plant Based Extracts and Cognition
Acute, randomized, placebo controlled, double blind, 4 arm crossover study to determine the effect of different combinations of plant based extracts on cognitive function and cerebral blood flow.
- Trial name
- CEOPTB (NCT02202629)
- Testing
- Beverage containing plant based extracts
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Nutrition Processes
Effects of Nutraperf Consumption in Runners
Exercise has numerous health benefits. Nevertheless, when exercise duration is ~45 min or longer and intensity moderate to intense, it may induce different troubles, for example: hypoglycemia, peripheral and central fatigue…
- Trial name
- NCT00799630
- Testing
- Carbohydrate drink
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Lescuyer Laboratory
Fatigue, Cognitive Function
Radicle Energy VBMTM: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes
Radicle Energy VBMTM: A randomized, double-blind, placebo- controlled direct-to-consumer study assessing the impact of health and wellness products on fatigue and related health outcomes.
- Conditions
- Fatigue, Cognitive Function, Global Mental Health, Sleep Disturbance
- Trial name
- NCT07653724
- Testing
- Energy Active Product 1
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Cognitive Function, Fatigue
A Clinical Trial to Evaluate the Effects of a Supplement on Cognitive Function and Energy Levels
This study evaluates the effects of Artah's Cellular Hydration electrolyte supplement on cognitive function and energy levels in healthy adults aged 25-60 who experience mild to moderate fatigue, brain fog, or related symptoms.
- Conditions
- Cognitive Function, Fatigue, Energy Levels, Mental Clarity
- Trial name
- NCT07755475
- Testing
- Cellular Hydration Supplement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Artah Nutrition Limited
Psychological Stress, Anxiety
NeuroFinance Human Stress Trial During Financial and Informational Volatility
The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven…
- Conditions
- Psychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System Dysfunction
- Trial name
- NFHST (NCT07622589)
- Testing
- Wearable Physiologic Monitoring Platform
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Mental Fatigue
Brain Oxygenation Marker for Cognitive Function in Healthy Adults
This study aims to identify a cortical oxygenation marker for cognitive function using functional Near Infrared Spectroscopy in healthy adults.
- Trial name
- NCT05559034
- Testing
- Cognitive intervention
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Improves Daytime Energy Levels, Reduces Afternoon Energy Crashes and Midday Fatigue
A Clinical Trial to Evaluate the Effects of Adrenal Adapt on Sleep Quality, Daytime Energy, Stress Resilience, and Cognitive Performance.
This is a single-group, open-label, uncontrolled clinical trial designed to evaluate the effects of Adrenal Adapt, a commercially available dietary supplement, on sleep quality, daytime energy, stress resilience, and cognitive…
- Conditions
- Improves Daytime Energy Levels, Reduces Afternoon Energy Crashes and Midday Fatigue, Improves Overall Sleep Quality and Restorative Sleep, Helps People Fall Asleep Faster and Wake Less During the Night
- Trial name
- NCT07893561
- Testing
- Adrenal Adapt
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bioligent
Attention Difficulties
Guayusa: The Effect of an Herbal Extract on Alertness and Mental Fatigue
The primary objective of this randomized, double-blind, placebo-controlled, cross-over study is to assess the acute effects of a novel ingredient, guayusa on alertness and mental fatigue compared to a placebo.
- Trial name
- NCT05530915
- Testing
- Gel capsule
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Exercise Addiction
Effects of Supplementation With Ginseng and BCAA Improved Central Fatigue and Enhanced Attention During Exercise
The main purpose of the present study is to determine the effects of acute and short-term (14 days) ginseng combined with branch chained amino acids supplementation on endurance exercise performance and the ability of…
- Trial name
- NCT05129917
- Testing
- Gojinsen® drinks
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Stress
Effects of Ginseng on Stress, Emotional and Cognitive Processing
This study aims to confirm the positive effect of the Red Panax Ginseng on the cognitive performance and regulation of stress and fatigue in adults with moderate stress level.
- Trial name
- GNIZEN (NCT06414486)
- Testing
- Dietary supplement group
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Botalys
Brain Fog, Cognitive Health
Modulation of the Brain Fog Scale by Eicosapentaenoic Acid Monoglycerides (MAG-EPA).
A growing body of studies shows that omega-3s act directly in molecular signaling pathways that reduce inflammation and are thought to have a positive effect on cognitive health.
- Trial name
- NBF-MG01 (NCT06695910)
- Testing
- Monoglyceride Eicosapentaenoic acid (omega-3), Sunflower Oil
- Where
- 2 sites in Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Samuel Fortin
Mental Fatigue, Alertness
Effect of Coffeeberry on Mood and Cognitive Performance
The primary aim of this randomised, double-blind, placebo-controlled, cross-over study is to assess the short-term cognitive effects of two beverages containing 100 and 300 mg coffeeberry extract (obtained from the fruit of the…
- Conditions
- Mental Fatigue, Alertness, Mood, Cognition
- Trial name
- NCT04975802
- Testing
- Coffeeberry, Caffeine
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Cognitive, Mood and Cognitive Performance
The Acute Effects of Onnit Alpha Brain on Cognition and Mood States
The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive…
- Conditions
- Cognitive, Mood and Cognitive Performance, Sleep Deprivation, Executive Function (Cognition)
- Trial name
- NCT07495592
- Testing
- Alpha Brain proprietary cognitive dietary supplement, Alpha Brain 2.0 proprietary cognitive dietary supplement
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Fatigue
Evaluate the Effectiveness and Safety of the Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health
The purpose of this study is to assess the effectiveness and safety of the Alpinia galanga formulation, Theacrine formulation, and Caffeine formulation on fatigue, mental acuity, and cognitive health among overall healthy…
- Trial name
- NCT05170113
- Testing
- Alpinia galanga formulation, Theacrine formulation, Caffeine formulation
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Menopause, Sleep Disturbance
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
A randomized, double-blind, placebo-controlled, direct-to-consumer trial assessing the impact of health and wellness products on hormonal health and associated health outcomes in women with menopausal health issues
- Conditions
- Menopause, Sleep Disturbance, Anxiety, Depression
- Trial name
- NCT06749288
- Testing
- Radicle Revive Active Study Product 4.1 Usage
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Premenstrual Syndrome, Premenstrual Dysphoric Disorder
CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life
This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device…
- Conditions
- Premenstrual Syndrome, Premenstrual Dysphoric Disorder, Dysmenorrhea, Endometriosis
- Trial name
- CREST (NCT07679074)
- Testing
- Lutea Transcranial Direct Current Stimulation (tDCS) Device, Samphire Guided Care Program
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samphire Group, Inc.