Clinical trials: Cognitive Function, open to volunteers
Post Intensive Care Syndrome (PICS), Cognitive Impairment
Eye Tracking for Early Identification of Post-ICU Cognitive Impairment
Some patients may have problems with memory, attention, thinking speed, or other cognitive functions after leaving the intensive care unit (ICU). This is called post-ICU cognitive impairment.
- Trial name
- NCT07676864
- Where
- China
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Schizophrenia
A 20-Year Follow-up of First Episode Psychosis: Longitudinal Effects of Early Treatment Strategies and Relapse
The study aims to address the following questions: 1. Do subgroups defined by early medication choices, relapse, and medication taken over 20 years differ in clinical, cognitive, and functional outcomes? 2.
- Trial name
- NCT07616999
- Where
- China
- Volunteers
- 178 people
- Sponsor
- The University of Hong Kong
Alzheimer Disease
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease.
- Trial name
- ADVISe (NCT04576793)
- Testing
- 11C-ER176, 18F-MK6240, 18F-Florbetaben
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Schizophrenia
Improving Real-world Function for Persons with Schizophrenia: a Single-case Experimental Design
Existing treatment for individuals with psychosis primarily targets positive symptoms but has only modest effects on cognition and negative symptoms.
- Trial name
- ImproFunc (NCT06790186)
- Testing
- Perceive, Recall, Plan and Perform intervention Interventions:
- Volunteers
- 27 people
- Sponsor
- Sykehuset Innlandet HF
Sleep, Circadian Rhythm
Morning Bright Light Therapy and Daytime Functioning in University Students
This study tests whether a week of morning bright light therapy changes how well healthy young adults sleep and how alert, positive, and mentally sharp they feel during the day.
- Conditions
- Sleep, Circadian Rhythm, Daytime Sleepiness, Mood
- Trial name
- BLIGHT (NCT07685262)
- Testing
- Bright light therapy (10,000 lux light box)
- Where
- Hong Kong
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Older Adults
Social Participation Program for Older Adults in Nursing Homes
The goal of this clinical trial is to learn whether a multi-level social participation program can help improve social engagement and slow down cognitive decline in older adults living in nursing homes.
- Trial name
- NCT07079124
- Testing
- Multi-level Social Participation Intervention, Health Education
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Autism Spectrum Disorder (ASD), Transcranial Direct Current Stimulation (tDCS)
Transcranial Direct Current Stimulation in Children With Autism Spectrum Disorder
Background: Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation that has aroused increased interests in the past decade.
- Conditions
- Autism Spectrum Disorder (ASD), Transcranial Direct Current Stimulation (tDCS), Electroencephalography
- Trial name
- NCT06880159
- Testing
- tDCS with computerized cognitive training
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Type 2 Diabets Mellitus, Cognitive Ability, General
Cilostazol-Ginkgo for Cognitive Function in Elderly Diabetes
This exploratory pilot study aims to evaluate the cognitive improvement effects of combination therapy with cilostazol (200 mg) and ginkgo biloba extract (160 mg) in elderly patients with type 2 diabetes mellitus.
- Trial name
- NCT06989697
- Testing
- Cilostazol / Ginko Leaf Dried Ext.
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Investigating Memory and Physical Activity After Cancer Treatment in Survivors of Adolescent and Young Adult Cancers
This study evaluates relationships among physical activity, thinking, and memory after cancer treatment in survivors of adolescent and young adult cancers.
- Trial name
- IMPACT (NCT06880861)
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Dementia, Mild Cognitive Impairment (MCI)
Dementia and Mild Cognitive Impairment: Assessment of Cognitive Functioning, Functional Autonomy, and Neuropsychiatric Symptoms.
Dementia, in its various forms, is characterized by a generalized cognitive decline that can significantly compromise personal autonomy and quality of life.
- Trial name
- RE-MIDA (NCT07287410)
- Testing
- none - observational study
- Where
- Italy
- Volunteers
- 151 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
PTSD, Cognitive Impairment
(Neuro)Cognitive Remediation for Adults With OSIs
(Neuro)Cognitive remediation (CR) is an intervention for people experiencing cognitive impairments that interfere with their daily functioning.
- Conditions
- PTSD, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT06813378
- Testing
- (Neuro)Cognitive Remediation
- Volunteers
- 20 people
- Sponsor
- Nova Scotia Health Authority
Healthy, Older Adults
The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.
This pilot study will compare the effect of combining dietary nitrate and caloric restriction versus dietary nitrate alone. The participant will be contacted, having responded to an advertisement on social media and posters, to…
- Conditions
- Healthy, Older Adults, Overweight and Obesity
- Trial name
- CRNitrateMRI (NCT06151015)
- Testing
- Nitrate-rich beetroot juice plus calorie-restricted diet, Nitrate-rich beetroot juice plus weight-maintenance diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Moira Taylor
Preclinical Alzheimer's Disease, Alzheimer Disease
Alzheimer's Tau Platform: Master Protocol
The goal of the Alzheimer's Tau Platform (ATP) is to evaluate the safety and effectiveness of tau-directed therapies, alone or in combination with the anti-amyloid monoclonal antibody, donanemab, in adults aged 50-80 with late…
- Conditions
- Preclinical Alzheimer's Disease, Alzheimer Disease, Prodromal Alzheimer's Disease
- Trial name
- ATP (NCT06957418)
- Testing
- AADvac1, Tau2
- Where
- 7 sites in United States
- Volunteers
- 900 people
- Sponsor
- Paul S. Aisen
Huntington Disease
Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease
The purpose of this research study is to determine whether an implantation of hNSC-01 is a safe and tolerable study intervention for Huntington's disease. This study is the first time that hNSC-01 is being tested in people.
- Trial name
- REGEN4HD (NCT07451613)
- Testing
- hNSC-01
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Leslie Thompson
Alzheimer Disease
F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (DIAN Project)
The purpose of this research study is to evaluate a new radioactive compound used in positron emission tomography (PET) scans in identifying tau tangles (a certain protein that might be associated with Dominantly Inherited…
- Trial name
- AV ADAD (NCT02414178)
- Testing
- F 18 T807
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
Impact of Cognitive Impairment on Chronic Pain in Breast Cancer
Breast cancer treatments are associated with frequent and sometimes severe adverse effects that may significantly impair quality of life and lead to functional disability.
- Trial name
- Cactus (NCT07877376)
- Testing
- Evaluation of cognitive functions in patients with beast cancer
- Where
- France
- Volunteers
- 182 people
- Sponsor
- Nadine ATTAL
Cognitive Impairment, Cognitive Decline
Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy
Randomized, placebo-controlled, double-blinded, parallel group clinical trial to investigate if 6 months of oral lithium tablets (S-lithium 0,5-1,0 mmol/l) will prevent cognitive decline after brain radiotherapy in pediatric…
- Conditions
- Cognitive Impairment, Cognitive Decline, Radiotherapy Side Effect, Radiotherapy; Complications
- Trial name
- LiBRA (NCT06051240)
- Testing
- Lithium
- Where
- 2 sites in Sweden
- Volunteers
- 84 people
- Sponsor
- Region Stockholm
Age-related Hearing Loss
Prediction of Age-Related Hearing Loss Based on Comprehensive Risk Factors
This study aims to develop a predictive model for age-related hearing loss (ARHL) based on multi-source risk factors and artificial intelligence techniques.
- Trial name
- NCT07612618
- Testing
- Not applicable- observational study
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease
Safety Assessment of Leronlimab and Its Effect on Brain Inflammation in Alzheimer's Disease
The present study will administer the drug leronlimab to 20 participants who are above 50 years old with Alzheimer's disease (AD) or mild cognitive impairment (MCI) due to AD.
- Trial name
- SALIENT-AD (NCT07553338)
- Testing
- Leronlimab (700mg)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Aged, Aged Subject
CREM - Clinical and Functional Outcomes in a Controlled Clinical Trial with Older Adults
To evaluate and compare the effects of different types of physical exercise on clinical and functional outcomes in the elderly. 240 community-dwelling elderly individuals of both sexes, sedentary, will be recruited for twelve…
- Trial name
- CREM (NCT06638697)
- Testing
- Free walking, Nordic walking, Dance
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
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