Clinical trials: Cognitive Function Assessment
Mild Cognitive Impairment
A Clinical Trial to Evaluate the Efficacy and Safety of Choline Alfoscerate Compared to Placebo in Patients With Degenerative Mild Cognitive Impairment
This is a multi-center, randomized, double-blind, placebo-controlled, Phase IV trial to evaluate the efficacy and safety of Choline Alfoscerate compared to placebo in patients with degenerative mild cognitive impairment.
- Trial name
- NCT05041790
- Testing
- Choline Alfoscerate
- Where
- South Korea
- Volunteers
- 418 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Cognitive Impairment, Physical Disability
Circle Game Collaborative--Freddie the Frog
Families who have children with disabilities experience more challenges in interacting with their children than families who have children without disabilities.
- Trial name
- NCT05522946
- Testing
- Gameplay between parent and child or adolescent with or without a disability
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Traumatic Brain Injury, Acquired Brain Injury
Comparative Utility of Clinical Balance Measures in Traumatic Brain Injury
The purpose of this research study is to investigate how useful three balance tests are in predicting fall risk in the individual with traumatic brain injury (TBI).
- Conditions
- Traumatic Brain Injury, Acquired Brain Injury, Accidental Falls
- Trial name
- NCT02696538
- Testing
- Functional Gait Assessment, mini-Balance Evaluation Systems Test, Berg Balance Scale
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Parkinson's Disease
Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
In phenotypic animal models of Parkinson's Disease (PD), chronic physical exercise has produced nigrostriatal neuroprotection and symptom improvement, provided training was of high-intensity and prolonged duration (>3 months in…
- Trial name
- AEROPROTECT (NCT04046276)
- Testing
- High Intensity Aerobic program, Conventional Physical Therapy, Medium Intensity Aerobic program
- Where
- 3 sites in France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Physical Activity, Adolescents
Effectiveness of a Multicomponent Intervention to Promote Physical Activity Levels During the School Day (MOVESCHOOL)
Study based a multicomponent school-based intervention during the school-day (i.e., Physically active learning, active breaks, and active recess) on Physical Activity, health, educational, and cognition outcomes in adolescents.
- Conditions
- Physical Activity, Adolescents, Physical Fitness, Cognition
- Trial name
- MOVESCHOOL (NCT06254638)
- Testing
- Multicomponent school-based intervention.
- Where
- Spain
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Gait Disorders, Neurologic, Gait Disorders in Old Age
ExerG: Video Game-based Physical Cognitive Training for Patients: a Usability Study
Video game-based training programs, in the following referred to as "exergames" are an innovative digital training approach to simultaneously train physical and cognitive functions and increase training motivation for various…
- Conditions
- Gait Disorders, Neurologic, Gait Disorders in Old Age, Gait Disorder, Sensorimotor, Balance; Distorted
- Trial name
- ExerGetic (NCT05967078)
- Testing
- ExerG
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Frank Behrendt
Dementia, Cognitive Impairment
Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
In this study, the investigators implement FDG-PET imaging for clients in the Geriatric Psychiatry department at The Royal Ottawa Hospital (ROH) and evaluate the impact of this advanced imaging technique on client care.
- Conditions
- Dementia, Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT05428475
- Testing
- [18F]FDG-PET Scan
- Volunteers
- 15 people
- Sponsor
- Tim Lau
Anhedonia, Cognitive Function
Pitolisant Effects on Affect and Cognition Exploratory Study (PEACE Study)
The goal of this study is to investigate the effects of selective histamine 3 antagonist pitolisant on brain function and cognition in healthy individuals. The main questions it aims to answer are: 1.
- Trial name
- PEACE (NCT05849675)
- Testing
- Pitolisant 17.8 MG [Wakix]
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Williams Syndrome
Clemastine Treatment in Individuals With Williams Syndrome
This study explores the neurobiological etiology of Williams syndrome and potential therapeutic targets for associated social, motor, and cognitive abnormalities.
- Trial name
- NCT06087757
- Testing
- Open Label Clemastine with a blinded randomize withdrawal
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Alzheimer's Type Dementia
A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease
The objective is to demonstrate that donepezil hydrochloride 10 mg/day has superior efficacy compared with placebo in cognitive function in Chinese subjects with severe Alzheimer's Disease.
- Trial name
- NCT01404169
- Testing
- E2020
- Where
- 32 sites in China
- Volunteers
- 260 people
- Sponsor
- Eisai Limited
Healthy
Sensitivity of Project: EVO Monitor Cognitive Measurements to Pharmacological Agents
This is a study in adults to assess the sensitivity of Project: EVO Monitor cognitive measurements to two short-acting cognitively active pharmacological agents.
- Trial name
- NCT02822937
- Testing
- Methylphenidate, Triazolam, Project: EVO
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Akili Interactive Labs, Inc.
Head and Neck Cancer
Comprehensive Assessment of Head and Neck Cancer Survivors
Cancer survivorship has dramatically improved within the last four decades and a greater number of Americans are living after cancer diagnosis.
- Trial name
- CAHNCA (NCT01222481)
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Jay F. Piccirillo, MD
Alzheimer Disease, Dementia
ANNE Vital Sign System Remote Sleep Assessment
Sleep apnea is characterized by temporary pauses or stops to participant's breathing. Currently, sleep apnea is diagnosed using an in-lab sleep study, which involves spending a night in a sleep laboratory hooked up to wires on…
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Sleep Apnea
- Trial name
- NCT05669495
- Testing
- ANNE Vital Sign System
- Where
- Canada
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
ICU Survivors
Integrated Recovery Program for Critical Illness
This study aims to investigate the effects of the Integrated Critical Illness Aftercare and Recovery Enhancement (I-CARE) program on reducing healthcare burden and improving functional outcomes in ICU survivors.
- Trial name
- iCARE (NCT06997822)
- Testing
- LINE Bot-Based Remote Care Combined with In-Person Post-ICU Clinic
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment
ThinkingFit: Combined Physical, Cognitive and Social Treatment in Mild Cognitive Impairment (MCI)
Dementia is serious problem and around 700 000 people are affected in the UK alone. Currently there is no cure however early diagnosis and effective treatment offers hope for reducing the impact.
- Trial name
- ThinkingFit (NCT01603862)
- Testing
- ThinkingFit programme
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- Dr Thomas Dannhauser
Alzheimer Disease
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
The main purpose of this study is to evaluate the safety of LY3954068 in participants with early symptomatic Alzheimer's Disease (AD).
- Trial name
- NCT06297590
- Testing
- LY3954068, Flortaucipir F18
- Where
- 10 sites in United States, Japan and 1 more
- Volunteers
- 48 people
- Sponsor
- Eli Lilly and Company
Alzheimer Disease, Cognitive Decline
Smart Cupboard-based System for Memory Assessment in Alzheimer's Patients
The main objective of the research is to create a tool that can make a good diagnosis of cognitive abilities in Alzheimer's patients.
- Trial name
- NCT05202197
- Testing
- Smart cupboard
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Universidad de Zaragoza
Dementia, Alzheimer Disease
Integrating eSAGE With EHR Data Using Machine Learning for the Early Detection and Monitoring of Cognitive Impairment in Individuals
The goal of this observational trial is to leverage the electronic Self-Administered Gerocognitive Examination (eSAGE), a variety of metadata (a set of data that describes and gives information about other data) collected during…
- Conditions
- Dementia, Alzheimer Disease, Mild Cognitive Impairment, Worried Well
- Trial name
- NCT06017505
- Testing
- electronic self administered gerocognitive examination (eSAGE)
- Where
- United States
- Volunteers
- 1,486 people
- Sponsor
- Douglas Scharre
Cognitive Dysfunction, Motor Skills Disorders
Impact of Sociodemographic, Psychological, and Quality of Life Factors on Dual-Task Performance in Elderly Iraqis
This study investigates the impact of sociodemographic, psychological, and quality of life factors on dual-task performance in elderly individuals living in Iraq.
- Conditions
- Cognitive Dysfunction, Motor Skills Disorders, Aging
- Trial name
- SociQ-DT (NCT06476561)
- Testing
- - Sociodemographic Assessment - Psychological Assessment - Quality of Life Assessment - D
- Where
- Turkey (Türkiye)
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Mild Cognitive Impairment
Application and Revision of Montreal Cognitive Assessment in Chinese Retirees
The study was designed to employ MOCA to screen mild cognitive impairment (MCI) in military retirees and to analyze the associated risk factors. As such, MOCA was revised to be validated for the Chinese context.
- Trial name
- ARMOCA (NCT02483754)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital