Clinical trials: Cognitive Function Decline
Cognitive Impairment
The Mental Activity and eXercise Trial for Seniors
The primary objective of this study is to conduct a randomized, controlled trial to determine whether engaging in mental activity or exercise, either alone or in combination, improves cognitive function in non-demented, inactive…
- Trial name
- MAX (NCT00522899)
- Testing
- Group 1, Group 2, Group 3
- Where
- 2 sites in United States
- Volunteers
- 126 people
- Sponsor
- University of California, San Francisco
Diet Modification, Cognitive Decline
Multicultural Healthy Diet to Reduce Cognitive Decline
This is a pilot randomized controlled clinical trial is designed to investigate whether the Multicultural Healthy Diet (MHD), an anti-Inflammatory diet tailored to a multi-cultural population, can improve cognitive functioning in…
- Conditions
- Diet Modification, Cognitive Decline, Cognitive Change
- Trial name
- MHD (NCT03240406)
- Testing
- Multicultural Healthy Diet, Usual Diet plus Self-Care
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Postoperative Cognitive Dysfunction
Evaluation of the Ketogenic Diet to Improve Post Operative Cognitive Decline in Cardiac Surgery
Postoperative cognitive decline (POCD) is a significant neurological problem that commonly follows coronary artery bypass grafting surgery (CABG) in elderly patients.
- Trial name
- NCT06480708
- Testing
- Ketogenic diet, Control diet
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Bipolar Disorder (BD), Depression - Major Depressive Disorder
Epigenetic Enhancement of Cognitive Training in Aging Mood and Schizophrenia Spectrum Disorder Populations
The aim of this clinical trial is to investigate the effects of a three-week virtual reality-based cognitive remediation training (VR-CRT) programme in combination with daily intake of a histone deacetylase inhibitor (HDACi)…
- Conditions
- Bipolar Disorder (BD), Depression - Major Depressive Disorder, Cognitive Impairment, Schizophrenia Disorders
- Trial name
- EPIC (NCT07404085)
- Testing
- Virtual Reality-based cognitive remediation therapy (VR-CRT), Virtual Reality-based control treatment (VR-CT), HDACi butyrate
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Old Age; Dementia, Aging
Compensatory Brain Activity in Older Adults.
There are two important aspects in which the present project will allow to enrich our understanding of compensatory brain activity in older adults.
- Conditions
- Old Age; Dementia, Aging, Cognitive Decline
- Trial name
- BrainAct (NCT06235840)
- Testing
- working memory adaptive training, multi-domain non-adaptive control training
- Where
- Poland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Kazimierz Wielki University
Mild Cognitive Impairment (MCI), Alzheimer Disease
Innovative Cognitive Impairment Case Finding and Engagement for Diverse Participation in Alzheimer's Disease Care, Treatment, And Research
Recent studies have highlighted the potential use of electronic health record (EHR) data for scalable and less biased identification of people who may have or be at risk of developing MCI or ADRD at the population level.8,9 Using…
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Dementia
- Trial name
- INCLUDE (NCT07016178)
- Testing
- Acceptability and Feasibility of Twistle messaging for PDM+ patients
- Where
- United States
- Volunteers
- 3,454 people
- Sponsor
- Indiana University
Down Syndrome
Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome
The purpose of this study is to test in adults with Down Syndrome the safety, tolerability and immunogenicity of a vaccine, ACI-24.
- Trial name
- 3-Star (NCT02738450)
- Testing
- ACI-24 low dose, ACI-24 high dose
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- AC Immune SA
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention and Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- Quest-Tablet (NCT05625425)
- Testing
- LabyrinthVR software, Labyrinth Tablet software, Labyrinth VR wireless
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cardiovascular Health, Functional Health
Beetroot Extract and Quality of Life in Adults Aged 75 and Over
The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging.
- Conditions
- Cardiovascular Health, Functional Health, Cognitive Function Decline, Physical Performance Decline in Older Adults
- Trial name
- BERS (NCT07666685)
- Testing
- Beetroot Extract Supplementation
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Community-Dwelling Older Adults, Aging
The Efficacy of a Technology-Assisted Block Training Program on Cognitive Function, Hand Dexterity, and Grip Strength in Community-Dwelling Older Adults: A Mixed-Methods Research
Block-building activities represent a promising tool for enhancing cognitive and hand function in older adults. When integrated with technological support, they offer personalized training advantages; however, their comprehensive…
- Conditions
- Community-Dwelling Older Adults, Aging, Cognitive Decline, Hand Dexterity
- Trial name
- NCT07315724
- Testing
- Technology-Assisted Block Training Program
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Cognitive Decline, Dementia Prevention
Small Monetary Incentives for Digital Cognitive Training Adherence in Community-Dwelling Older Adults
This study aims to find out whether small daily monetary rewards can help older adults living in the community to regularly complete digital cognitive training.
- Trial name
- NCT07913243
- Testing
- Digital cognitive training, Monetary incentive 0.2 CNY/day, Monetary incentive 0.5 CNY/day
- Where
- 5 sites in China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Ovarian Cancer, Cognitive Decline
Predictors of Cognitive Decline and Delirium in Older Women With Ovarian Cancer
Cognitive decline and delirium are common geriatric syndromes that adversely affect treatment adherence, functional independence, quality of life, and survival in older adults with cancer.
- Conditions
- Ovarian Cancer, Cognitive Decline, Delirium
- Trial name
- CROWN (NCT07716800)
- Volunteers
- 205 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Mild Cognitive Impairment, Alzheimer Disease
Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers
This study aims to provide clinical validation of EyeQuant, a fully automated retinal image analysis system for computation of vascular biomarkers indicative of cognitive disorders, using retinal fundus photographs collected from…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Vascular Dementia
- Trial name
- NCT04567745
- Testing
- Retinal fundus photography
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Aging, Focus Groups
Development of Web-Based Mind-Body Trainings for Adults With Subjective Concerns
The goal of this observational study is to develop online, self-paced mindfulness (iMBSR) and lifestyle education (iLifeEd) programs for adults with cognitive concerns.
- Trial name
- iMBT (NCT06410807)
- Testing
- Focus groups
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ohio State University
Brain Infarction, Hypertension
Angiotensin II Receptor Blockers (ARB) and ACE Inhibitors (ACEI) on Silent Brain Infarction and Cognitive Decline
The purpose of this study is to elucidate whether or not angiotensin II receptor blockers (ARB) are more beneficial or equal to angiotensin converting enzyme inhibitors (ACEI) on development or progression of silent brain…
- Trial name
- NCT00126516
- Testing
- Angiotensin II Receptor Antagonists, Angiotensin-converting Enzyme Inhibitors
- Where
- Japan
- Volunteers
- 395 people
- Sponsor
- Nara Medical University
Alzheimer Dementia, Dementia Disorders
Medication Repurposing to Stop Cognitive Decline in Dementia
Dementia creates a great personal and societal burden and there are currently no treatments to stop memory loss. Many patients with dementia take medications to treat other conditions, e.g. high blood pressure and cholesterol.
- Trial name
- NCT05817188
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 100,000 people
- Sponsor
- Karolinska Institutet
Cognitive Decline
Effectiveness of Reminiscence Therapy Versus Cognitive Stimulation in Older Adults With Cognitive Decline
Although data suggest that non-pharmacologic therapies such as Reminiscence Therapy (RT) and Cognitive Stimulation (CS) can potentially maintain or reverse this trend, cognitive impairment can be a precursor to neurodegenerative…
- Trial name
- TRvsCS (NCT05187572)
- Testing
- Group intervention
- Where
- Portugal
- Volunteers
- 106 people
- Sponsor
- Paulo Costa
Parkinson Disease, Prodromal Stage
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
α-Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are the second most common neurodegenerative diseases.
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- ALPHA-FIT (NCT07324330)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Neurocognitive Disorders, Anesthesia
Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study
Traditionally, general anesthesia is maintained with inhalational anesthesia (GAS), but there is a gap in knowledge regarding whether intravenous anesthesia (IV) can prevent deleterious postoperative outcomes in the geriatric…
- Conditions
- Neurocognitive Disorders, Anesthesia, Post-operative Delirium, Post-operative Cognitive Dysfunction
- Trial name
- TIVA GAS (NCT06036095)
- Testing
- Sevoflurane, Propofol
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cognitive Decline
Happy Older Latinos Are Active - Cognitive Decline
The purpose of this study is to look at the best ways to prevent cognitive decline (loss of memory and/or functioning) in midlife and older Latino adults living with HIV.
- Trial name
- HOLA-CD (NCT04791709)
- Testing
- Happy Older Latinos are Active (HOLA)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami