Clinical trials: Cognitive Function Decline
Endothelial Dysfunction, Blood Brain Barrier Defect
Endothelial Injury Mechanism in Elderly Patients Undergoing Major Surgery
The incidence of postoperative cognitive injury is high in elderly patients, especially after major surgery. The relevant pathophysiological mechanisms are still unclear, and the possible mechanisms that have been proposed so far…
- Conditions
- Endothelial Dysfunction, Blood Brain Barrier Defect, Postoperative Cognitive Dysfunction
- Trial name
- NCT03639896
- Testing
- Dexmedetomidine, Saline
- Where
- 2 sites in China
- Volunteers
- 464 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Quality of Life, Cognitive Decline
Health and Energy Through Active Living Every Day After Cancer Intervention for Cancer Survivors
The purpose of the Health and Energy through Active Living Every Day (HEALED) intervention, is to examine the effect of a web-based intervention on changes in device-measured physical activity (light and moderate-to-vigorous…
- Conditions
- Quality of Life, Cognitive Decline, Fatigue, Sleep
- Trial name
- HEALED (NCT05356988)
- Testing
- Physical activity experiment, Balance and flexibility control
- Where
- United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- American Cancer Society, Inc.
Older Adults, Depression
Educational and Cultural Engagement and Incidence of Health Adverse Events
This study evaluated if the social and cultural activities decrease the incidence of dementia and frailty conditions.
- Conditions
- Older Adults, Depression, Cognitive Decline
- Trial name
- NCT03987360
- Testing
- Observational
- Where
- Canada
- Volunteers
- 30,000 people
- Sponsor
- Jewish General Hospital
Parkinson's Disease, PD
iPACES v3 MCI NIA Protocol Copied for iPACES v4 PD NINDS
The primary purpose of this study is to attempt to replicate and extend promising pilot findings regarding the cognitive benefits of in-home neuro-exergaming with iPACES (interactive Physical and Cognitive Exercise System v3) for…
- Conditions
- Parkinson's Disease, PD, Mild Cognitive Impairment, MCI
- Trial name
- iPACES-PD (NCT05810454)
- Testing
- iPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- iPACES LLC
Mild Cognitive Impairment, Dementia, Mild
The Brain Health Champion Study
6-month, randomized, controlled investigation measuring the effect of increased clinical contact and personalization compared to standard physician counseling on adherence to consensus-based, brain health recommendations for…
- Conditions
- Mild Cognitive Impairment, Dementia, Mild, Subjective Cognitive Decline, At Risk for Cognitive Decline
- Trial name
- BHC (NCT03772977)
- Testing
- Brain Health Champion
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cognitive Decline, Cognitive Impairment
Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity
Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group.
- Conditions
- Cognitive Decline, Cognitive Impairment, Aging, Motor Coordination or Function
- Trial name
- GIBKOP (NCT03860441)
- Testing
- Computerized cognitive training
- Where
- Slovenia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Insulin Resistance, Mild Cognitive Impairment
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
This randomized, double-blind, placebo-controlled, 8-week clinical trial is designed to evaluate the effects of Sabroxy®, a standardized extract of Oroxylum indicum bark, on insulin resistance and cognitive function in adults…
- Conditions
- Insulin Resistance, Mild Cognitive Impairment, Cognitive Decline, Neurodegenerative Disorders
- Trial name
- NCT07220694
- Testing
- Sabroxy®
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Cancer, Breast, Age-related Cognitive Decline
Older Breast Cancer Patients: Risk for Cognitive Decline
The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and…
- Conditions
- Cancer, Breast, Age-related Cognitive Decline, Cognitive Decline
- Trial name
- TLC (NCT03451383)
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Delirium, Cognitive Impairment
Redesigning the Surgical Pathway (PROMoTE)
Cognitive complications, that is problems with thinking and memory, are incredibly common after surgery, occurring in 10-50% of all older surgical patients.
- Conditions
- Delirium, Cognitive Impairment, Perioperative/Postoperative Complications, Cognitive Dysfunction
- Trial name
- PROMoTE (NCT05114876)
- Testing
- Multicomponent delirium-risk prevention bundle
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Sunnybrook Health Sciences Centre
Aging, Menopause
Estrogen Use in Protection From Cognitive Decline
This study is designed to assess the effects of estrogen therapy among postmenopausal women at risk for cognitive decline.
- Trial name
- NCT00097058
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Stanford University
Dementia, Mild Cognitive Impairment
HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study will investigate the validity of the HOGAR EEG/PSG monitoring kit designed by Bitbrain as a tool for characterizing and assessing cognitive function in older adults, as well as for detecting and predicting cognitive…
- Conditions
- Dementia, Mild Cognitive Impairment, Dementia Alzheimers, Dementia, Mixed
- Trial name
- Hogar (NCT06993207)
- Testing
- Home Lab
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bitbrain
Down Syndrome
A Study of ACI-24 in Adults With Down Syndrome
This study is a prospective multicenter, placebo-controlled, double-blind, randomized study to assess the effect of one dose ACI-24 versus placebo over a 74-week treatment period and 26-week safety follow-up period.
- Trial name
- NCT04373616
- Testing
- ACI-24
- Sponsor
- AC Immune SA
Mild Cognitive Impairment, Early Alzheimer's Disease
Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease
The purpose of this study is to determine whether daily treatment with this new treatment approach, called COT would be effective in protecting the memory and brain regions of people who are already showing signs of memory loss.
- Conditions
- Mild Cognitive Impairment, Early Alzheimer's Disease, Memory Impairment
- Trial name
- NCT05122598
- Testing
- COT
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Evon Medics LLC
Stroke
Long-term Follow-up After Stroke (The LAST-long Trial)
Despite the improved treatment of acute stroke over the past decades, those suffering from stroke still are at an increased risk of functional and cognitive decline in the long term.
- Trial name
- LAST-long (NCT03859063)
- Testing
- Intervention, Control
- Where
- 4 sites in Norway
- Volunteers
- 301 people
- Sponsor
- Norwegian University of Science and Technology
Cognitive Decline, Cognitive Function
A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory
This study will evaluate the efficacy of 1MD Nutrition's MindMD supplement in improving and maintaining cognitive function and memory.
- Trial name
- NCT06523218
- Testing
- MindMD Supplement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Scale Media Inc
Healthy Aging, Cognitive Change
The Effect of Transcranial Direct Current Stimulation on Visual Attention - Single Sessions
Recently, attention has been drawn to non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), in order to enhance cognitive functions by modifying brain plasticity and use it in…
- Conditions
- Healthy Aging, Cognitive Change, Cognitive Decline
- Trial name
- NCT04134195
- Testing
- Transcranial direct current stimulation
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Cognitive Decline, Age Problem
Clinical Outcomes in Elderly Patients With Preoperative Cognitive Dysfunction
Preexisting cognitive impairment, such as mild cognitive impairment, is common in many elderly patients who undergoing major surgeries.
- Conditions
- Cognitive Decline, Age Problem, Outcome
- Trial name
- NCT03143595
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhongda Hospital
Cognitive Decline, Cognitive Impairment
Effects of Accelerated rTMS on Cognitive Function
Cognitive impairment, including mild cognitive impairment (MCI) and mild dementia, is a growing public health challenge with limited effective treatment options.
- Trial name
- NCT07547319
- Testing
- TMS
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- San Francisco Neurology and Sleep Center
Cognitive Decline
An Investigation Into the Effects of a Wild Blueberry Powder and a Wild Blueberry Extract on Cognition in Older Adults
The purpose of this study is to determine whether a 6 month dietary intervention with wild blueberry powder and extract stabilised with L-cysteine and L-glutathione have an effect on cognitive performance in participants aged…
- Trial name
- NCT02446314
- Testing
- Wild Blueberry Powder - 450mg, Wild Blueberry Powder - 900 mg, Wild Blueberry extract 100mg
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cognitive Decline, Cognitive Symptoms
Oral Vitamin B12 Supplementation and Cognitive Performance in Elderly People
The purpose of this trial is to study the effects of oral vitamin B12 supplementation and vitamin B12 combined with folic acid supplementation on cognitive performance for 24 weeks in elderly people with mild vitamin B12…
- Trial name
- NCT00111267
- Testing
- vitamin B12 supplementation, vitamin B12 + folic acid combined supplementation
- Where
- Netherlands
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Wageningen University