Clinical trials: Cognitive Function Decline
Delirium, Cognitive Decline
Early Cognitive Intervention in Delirium
This is a randomized control trial to determine if early cognitive training and rehabilitation improve 4-month cognition in hospitalized older (>=65 years old) delirious patients with and without Alzheimer's disease and related…
- Conditions
- Delirium, Cognitive Decline, Dementia
- Trial name
- ECID (NCT04740567)
- Testing
- Cognitive Training, Goal Management Training
- Where
- 2 sites in United States
- Volunteers
- 283 people
- Sponsor
- Vanderbilt University Medical Center
Cognitive Decline, Mild, Cognition Disorders in Old Age
Effects of Wearable Sensor-based Interactive Cognitive-motor Training in Older Adults.
Based on research showing that cognitive-motor training programs help improve cognition in older adults with mild cognitive impairment, this program uses an interactive system to combine cognitive training with exercise.
- Conditions
- Cognitive Decline, Mild, Cognition Disorders in Old Age, Subjective Memory Decline
- Trial name
- NCT05983913
- Testing
- cognitive-motor training, cognition training
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Sahmyook University
Hypertension
Systolic Blood Pressure Intervention Trial
Elevated blood pressure (BP) is an important public health concern. It is highly prevalent, the prevalence may be increasing, and it is a risk factor for several adverse health outcomes, especially coronary heart disease, stroke…
- Trial name
- SPRINT (NCT01206062)
- Testing
- Intensive control of SBP, Standard control of SBP
- Where
- United States
- Volunteers
- 9,361 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cognitive Impairment, Dementia, Mild
Cognitive Screening Made Easy for PCPs - R33 Phase
This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care.
- Conditions
- Cognitive Impairment, Dementia, Mild, Cognitive Decline
- Trial name
- NCT06162026
- Testing
- RACS app
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Texas at Austin
Mild Cognitive Impairment (MCI), Self-Reported Memory Concerns
Transcranial Direct Current Stimulation Combined With Tai Chi for Dual-Task Mobility and Cognitive Function in Older Adults With Cognitive Decline
This randomized clinical trial evaluated the effects of transcranial direct current stimulation (tDCS) combined with Tai Chi on dual-task mobility, cognitive function, and physical function in older adults with mild cognitive…
- Trial name
- NCT07863518
- Testing
- Tai Chi, Transcranial Direct Current Stimulation
- Where
- 2 sites in China
- Volunteers
- 61 people
- Sponsor
- Shanghai University of Sport
Frailty, Cognitive Decline
The Effectiveness of a Dual-task Training Program
The purpose of this study is to explore the effect of a dual-task training intervention on cognitive function,physical function, depression symptoms and quality of life in middle-aged and elderly people with cognitive impairment.
- Trial name
- NCT06450119
- Testing
- walking training, cognition training
- Volunteers
- 196 people
- Sponsor
- Taipei Medical University
Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Postoperative Cognitive Decline, Inflammation, and Plasma Levels of Beta-amyloids
Postoperative cognitive dysfunction (POCD) can be a serious complication. The development of therapeutic strategies for the prevention and treatment of this condition requires the identification of subgroup of patients with the…
- Trial name
- NCT00850928
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Aging, Cognitive Decline
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular…
- Conditions
- Aging, Cognitive Decline, Sarcopenia, Frailty
- Trial name
- BRAIN-M (NCT05744167)
- Testing
- BFRT, MDRT
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
EEG Brain Oscillations, Alzheimer's Disease (AD) and Related Disorders
Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited.
- Conditions
- EEG Brain Oscillations, Alzheimer's Disease (AD) and Related Disorders, Cognitive Dysfunction
- Trial name
- NCT07087951
- Testing
- Gamma auditory stimulation device (active setting)
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Dementia, Mixed, Dementia, Vascular
Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy
The STAREE-Mind imaging sub-study will examine the effect of statin treatment over a 4-year period, compared with placebo, on markers of brain health.
- Conditions
- Dementia, Mixed, Dementia, Vascular, Dementia of Alzheimer Type, Cognitive Decline
- Trial name
- STAREE-Mind (NCT05586750)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 2 sites in Australia
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Monash University
Cognitive Decline
TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics.
The study is based on the hypothesis that the integration of biological, psychological, and social factors, according to the biopsychosocial paradigm, allows for more accurate identification of the different stages of the…
- Trial name
- TRIAD (NCT07399418)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Age-related Cognitive Decline
Impact of Formal Home Help on Quality of Life for Caregivers of Elderly Patients With Neurocognitive Impairment
The purpose of this prospective monocenter observational study is to assess the impact of the first introduction of formal home help (personalized autonomy allowance for seniors) on the quality of life of home caregivers of…
- Trial name
- PIAF-QVA (NCT04732312)
- Testing
- Home help
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Alzheimer's Disease (AD), Dementia
δ in Dementia Clinical Trials
The goal of this clinical trial is to demonstrate potential improvements in clinical trial methods relating to dementia and cognitive decline.
- Conditions
- Alzheimer's Disease (AD), Dementia, Cognitive Decline, Mild Cognitivie Impairment (MCI)
- Trial name
- δND (NCT05592678)
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Age-related Hearing Loss, Cognitive Decline
Auditory-Cognitive Dual-Task Intervention for Older Adults With Hearing Loss
Background: Age-related hearing loss (ARHL) is a common and irreversible condition that has been recently associated with cognitive decline and dementia. Hence, if ARHL is treated earlier, the risk of dementia might decrease.
- Conditions
- Age-related Hearing Loss, Cognitive Decline, Loneliness, Social Isolation
- Trial name
- NCT06486285
- Testing
- Auditory-cognitive dual-task training (ACDT)
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Cerebral Small Vessel Disease, Stroke
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
Cerebral small vessel disease (cSVD) is characterized by an alteration of the structure and function of small penetrating brain arteries.
- Conditions
- Cerebral Small Vessel Disease, Stroke, Cognitive Complaint
- Trial name
- SHIVA-CogNeuro (NCT07068620)
- Testing
- Home-based cognitive training
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bordeaux
Healthy Ageing, Cognitive Decline
Fitness, Ageing, and Bilingualism (FAB): The Benefits of Regular Exercise and Bilingualism for Language Abilities in Healthy Ageing.
This project investigates the relative benefits of regular physical activity and bilingualism for ameliorating cognitive decline in healthy ageing, with a particular focus on language function.
- Conditions
- Healthy Ageing, Cognitive Decline, Cardiorespiratory Fitness
- Trial name
- FAB (NCT07443189)
- Testing
- Home-Based HIIT
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Agder
Dysglycemia, Cognitive Deficit
Long-acting Exenatide and Cognitive Decline in Dysglycemic Patients
The overall objective of the study is to assess the potential effects of the long-acting GLP-1 analogue exenatide in preventing/slowing the progression of cognitive dysfunction and related biomarkers in dysglycemic/prediabetic…
- Trial name
- DRINN (NCT02847403)
- Testing
- Exenatide
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Mild Cognitive Impairment, Alzheimer Disease (AD)
Microbiome in Aging of Gut and Brain
The Microbiome in Aging Gut and Brain (MiaGB) Study is an observational study designed to examine whether differences in the microorganisms living in the gut and mouth are associated with cognitive health and cognitive decline.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease (AD), Dementia
- Trial name
- MiaGB (NCT07799402)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Healthy Volunteers
The Brain Alerting Mechanism Study
This is a study designed to look at how arousal levels in the brain change with age and how these changes influence thinking, vision, hearing and physical function in people of advanced age.
- Trial name
- NCT02050386
- Testing
- Cold pressor stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Alzheimer Disease, Cognitive Dysfunction
Renew NCP-5 for the Treatment of Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild Dementia of the Alzheimer's Type
A Randomized Pivotal Study of RenewTM NCP-5 for the Treatment of Mild Cognitive Impairment due to Alzheimer's Disease or Mild Dementia of the Alzheimer's Type is a pivotal, single blind, parallel design, multi-site study intends…
- Conditions
- Alzheimer Disease, Cognitive Dysfunction, Mild Cognitive Impairment, Mild Dementia
- Trial name
- NCT03721705
- Testing
- Renew NCP-5
- Where
- 12 sites in United States, Ireland and 1 more
- Volunteers
- 190 people
- Sponsor
- Renew Research, LLC