Clinical trials: Cognitive Function Decline
Cognitive Dysfunction
Fluoxetine Prevention Trial
Many cancer survivors are experiencing problems with memory and other cognitive abilities following cancer treatment. Little is known concerning the contributions of potentially preventive therapies on cognitive function, but…
- Trial name
- NCT01615055
- Testing
- Fluoxetine
- Where
- 2 sites in United States
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment (MCI), Oral Health
To Exam the Efficacy of Oral Health and Mediterranean Diet Interventions in Preventing Cognitive Decline Among Older Adults With Mild Cognitive Impairment
At present, many literatures have confirmed that the Mediterranean diet has the effect of delaying cognitive degeneration in patients with mild cognitive impairment, and can also slow down the speed of brain atrophy.
- Conditions
- Mild Cognitive Impairment (MCI), Oral Health, Mediterranean Diet
- Trial name
- NCT05865340
- Testing
- oral health + MED diet, oral health, MED diet
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Frail Elderly Syndrome, Cognitive Impairment
Taiwan Health Promotion Intervention Study for Elders
Objectives: 1-year multidomain health promotion on prevention of physical and cognitive decline for community-living older people.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Cognitive Decline
- Trial name
- THISCE (NCT03056768)
- Testing
- Multidomain intervention, Active control
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cognitive Decline, Vascular Health
Double-task Exercise in Older Adults at Risk of Cognitive Decline (MeMo-Health-Cog-3 Program)
Cerebral small vessel disease is a frequent cause of cognitive disability among older adults (OAs) in Mexico that imposes a significant burden on the health system and OAs' families.
- Trial name
- NCT04068376
- Testing
- Control excercise, "Mind and Movement for Cognitive Health in the Older Adult", Double-task exercise by older adults and their caregivers
- Where
- Mexico
- Volunteers
- 300 people
- Sponsor
- Instituto Mexicano del Seguro Social
Disability Physical, Cognition
Immersive Virtual Reality and Physical Exercise on Cognitive and Functional Performance in Hospitalized Older Patients
This study will be conducted in a hospital in Spain to investigate how a special intervention using immersive virtual reality technology can benefit hospitalized older adults with difficulties in their daily functionality.
- Trial name
- MOTOMED (NCT06340282)
- Testing
- Virtual reality, multicomponent exercise
- Where
- Spain
- Volunteers
- 212 people
- Sponsor
- Fundacion Miguel Servet
Refractive Errors
Cognitive Level Enhancement Through Vision Exams and Refraction
The investigators aim to conduct a mixed-method study in which a randomised controlled trial (RCT) and a descriptive qualitative study will be conducted.
- Trial name
- CLEVER (NCT05458323)
- Testing
- Free near and Distance Vision glasses
- Where
- India
- Volunteers
- 820 people
- Sponsor
- Queen's University, Belfast
Age-related Cognitive Decline
Effectiveness Of Computer-Based Cognitive Training in Age-Related Cognitive Decline
Background: Ageing is frequently accompanied by physiological changes that might result in a deterioration in physical and cognitive abilities, which frequently leads to institutionalization or the loss of autonomy.
- Trial name
- NCT06226103
- Testing
- Aerobic Exercise and Computerized Cognitive Training, Conventional Exercises and Brain health lectures
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Jazan
Aging
Improvement in Memory With Plasticity-Based Adaptive Cognitive Training (IMPACT)
The primary objective of this study is to evaluate the effects of a computer-based training program on the memory and cognitive abilities of mature individuals undergoing healthy aging.
- Trial name
- IMPACT (NCT00283010)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Educational DVDs
- Where
- United States
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Age-related Cognitive Decline, Mild Cognitive Impairment
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown.
- Conditions
- Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- NCT04171323
- Testing
- Cognitive Training, Computerized Cognitive Stimulation
- Where
- 6 sites in United States
- Volunteers
- 1,305 people
- Sponsor
- University of Alabama at Birmingham
Mild Cognitive Impairment, Cognitive Function
MIND Diet and Cognitive Function in Adults With MCI
To examine the effects of a 1-year cluster-randomized controlled intervention of MIND diet on cognitive function among 240 participants with mild cognitive function (MCI) aged 50 years and above from 4 communities.
- Conditions
- Mild Cognitive Impairment, Cognitive Function, Cognitive Decline
- Trial name
- NCT05975723
- Testing
- MIND diet education, Routine follow-up and general advice
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhejiang University
Cardiovascular Diseases, Diabetes
Kuopio Ischaemic Heart Disease Risk Factor Study (Nutrition Component)
To determine associations between dietary factors and risk of major chronic diseases and their risk factors
- Conditions
- Cardiovascular Diseases, Diabetes, Metabolic Syndrome, Cancer
- Trial name
- NCT03221127
- Volunteers
- 2,682 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Cognition Disorders in Old Age
Study on the Effectiveness and Safety of Two Olive Extract- Based (Olea Europea L. Folium) Supplements, Alone or Combined With a Mullein Extract (Verbascum Thapsus L. Herba Cum Floribus), for the Maintenance of Cognitive Function.
The goal of this clinical trial is to learn if two food supplements based on olive leaf extract, alone or combined with mullein extract, help maintain cognitive function in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT07586410
- Testing
- ACTIVE TREATMENT 1 - OLI-COGNITIVE FOOD SUPPLEMENT, ACTIVE TREATMENT 2 - OLI-VERB-COGNITIVE FOOD SUPPLEMENT
- Where
- Italy
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- ISTITUTO FARMOCHIMICO FITOTERAPICO: EPO SRL
Cognitive Dysfunctions, Cognitive Disorder
Additional Effects of Immersive vr 360 Degree Videos With Aerobic Exercises on Cognitive Functions in Elderly With Mild Cognitive Impairment
One of the key challenges faced by individuals with Mild Cognitive Impairment (MCI) is the decline in cognitive abilities, particularly global cognition, attention, and executive function, which are essential for maintaining…
- Conditions
- Cognitive Dysfunctions, Cognitive Disorder, Cognitive Decline
- Trial name
- NCT07242495
- Testing
- VR 360 degree Videos and Aerobic Chair Exercises intervention, Chair Aerobic Exercises
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Sleep, Alzheimer Disease
Napping, Sleep, Cognitive Decline and Risk of Alzheimer's Disease
This study aimed to pilot test a non-pharmacological (behavioral) treatment program targeting improved cognition through improving 24-h sleep-wake cycle in people with mild cognitive impairment (MCI) or mild Alzheimer's disease.
- Conditions
- Sleep, Alzheimer Disease, Cognitive Impairment, Aging
- Trial name
- NCT03256539
- Testing
- Sleep intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Francisco
Mild Cognitive Impairment, Alzheimer's Disease
Hormone and Information Processing Study
The purpose of this study is to examine the effects of testosterone (T) replacement on changes in thinking and memory, as well as mood in older men with mild cognitive impairment (MCI) and low T levels.
- Trial name
- HIP (NCT00539305)
- Testing
- testosterone gel
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Washington
Frontal Lobe Dementia, Frontotemporal Lobe Dementia
Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia
The primary objective of the study is to determine whether memantine is effective in slowing the rate of behavioral decline in frontotemporal dementia.
- Conditions
- Frontal Lobe Dementia, Frontotemporal Lobe Dementia, Semantic Dementia
- Trial name
- NCT00545974
- Testing
- memantine
- Where
- 9 sites in United States
- Volunteers
- 81 people
- Sponsor
- University of California, San Francisco
Spatial Navigation
Exploring to Remediate Behavioral Disturbances of Spatial Cognition
Spatial navigation (SN) has been reported to be one of the first cognitive domains to be affected in Alzheimer's disease (AD), which occurs as a result of progressive neuropathology involving specific brain areas.
- Trial name
- BDSC-MCI (NCT05944601)
- Testing
- Virtual and computer-based cognitive remediation training
- Where
- Italy
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline
This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and…
- Conditions
- Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Aging, Healthy
- Trial name
- NCT05014893
- Testing
- multi-modal targeted intervention (e.g., cognitive training, exercise, games)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Research Center for Rehabilitation Technical Aids
Cognitive Impairment, Cognitive Decline
Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)
This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognition Disorders, Cognitive Symptom
- Trial name
- MoCA-Norm (NCT03246269)
- Testing
- MoCA
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Andreas Monsch
Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease
TMS for Cognitive Decline in Aging and Preclinical AD
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical…
- Conditions
- Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
- Trial name
- NCT06956300
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital