Clinical trials: Cognitive Function Decline
Cognitive Dysfunction
Effects Of An 8-Weeks Mindfulness-based Intervention In Individuals With Subjective Cognitive Decline
The European Commission Horizon 2020 programme has funded the SCD-WELL trial to investigate the efficacy of mindfulness-based training to reduce anxiety in individuals with Subjective Cognitive Decline (SCD), in comparison to an…
- Trial name
- SCD-WELL (NCT03005652)
- Testing
- Mindfulness weekly courses for 8 weeks, Health education weekly courses for 8 weeks
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Parkinson Disease, Orthostatic Hypertension
Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in PD
The goal of clinical trial is to learn about how blood pressure fluctuations affect cognitive performance (thinking abilities) and brain blood flow in persons with Parkinson's disease with and without orthostatic hypotension (low…
- Conditions
- Parkinson Disease, Orthostatic Hypertension, Cognitive Change, Cognitive Impairment
- Trial name
- NCT06252376
- Testing
- Head-up tilt table
- Sponsor
- University of California, San Diego
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Delirium, Cognitive Decline
Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery
A parallel-group treatment, five-centre, participant and investigator masked, three-arm study to assess the safety and effectiveness of dexmedetomidine or clonidine infusion compared to placebo for the prevention of delirium and…
- Conditions
- Delirium, Cognitive Decline, Frailty
- Trial name
- ALPHA2PREVENT (NCT05029050)
- Testing
- Dexmedetomidine, Clonidine, Natriumchlorid
- Where
- 5 sites in Norway
- Volunteers
- 900 people
- Sponsor
- Oslo University Hospital
Delirium, Cognitive Impairment
Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
The purpose of this study is to determine what percentage of patients have cognitive problems (for example, memory or concentration difficulties) after surgery and anesthesia, what the characteristics of these problems are, and…
- Conditions
- Delirium, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- NCT03337282
- Testing
- Protocolized general anesthesia
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Cognitive Function, Cognitive Decline
Phospholipid-rich Dairy Extract for Cognitive Function
This clinical trial aims to determine whether dietary phospholipid-rich dairy milk extract improves cognitive function in adults with mild cognitive impairment and to assess its safety.
- Trial name
- NCT07011680
- Testing
- Phospholipid-rich dairy milk extract
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Dementia
Effects of Snoezelen Multisensory Therapy on Older Adults With Dementia
This randomized, controlled, longitudinal clinical trial investigates the effects of Snoezelen Multisensory Therapy (SMT) as an adjunct to standard therapy (ST) in older adults with dementia.
- Trial name
- SMT (NCT07657208)
- Testing
- Snoezelen Multisensory Therapy, Standard Therapy
- Where
- Slovenia
- Volunteers
- 63 people
- Sponsor
- University of Primorska
Type 2 Diabetes, Cognitive Decline in Older Adults
Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes
Type 2 diabetes and low levels of physical activity are associated with an increased risk of cognitive decline in older adults. Improving blood sugar control and engaging in regular exercise may help support brain health and…
- Trial name
- MOTIVATE (NCT07485062)
- Testing
- semaglutide, Moderate-Intensity Resistance Exercise, Balance and Tone (BAT) Exercise
- Where
- Canada
- Volunteers
- 164 people
- Sponsor
- Western University, Canada
Alzheimer Disease, Mild Cognitive Impairment
Quality Improvement PrecivityAD Clinician Survey (QUIP I)
There is an important unmet need for timely, non-invasive, and low-burden evaluation of patients presenting with mild cognitive impairment (MCI) and early dementia.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognitive Decline
- Trial name
- QUIP I (NCT05477056)
- Testing
- PrecivityAD blood test
- Where
- United States
- Volunteers
- 366 people
- Sponsor
- C2N Diagnostics
Preoperative Stress, Postoperative Cognitive Dysfunction
Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients.
Patients undergoing cardiac surgery often complain of anxiety before a major operation and the resulting stress. This circumstance is a risk factor for mental problems that may occur after the operation (e.g., delirium or memory…
- Conditions
- Preoperative Stress, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- DESTRESS-SURG (NCT05036538)
- Testing
- Intervention with natural sounds administered via headphones, Intervention with natural sounds and binaural beats administered via headphones, Intervention with natural sounds and virtual reality administered via headphones and head mounted display
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Heart and Brain Research Group, Germany
Hypertension, Cognitive Decline
The Heart & Mind Study
Older adults with subjective cognitive decline (SCD) may represent a portion of the population experiencing early sings of cognitive decline. Systolic hypertension is a major contributor to cognitive impairment.
- Conditions
- Hypertension, Cognitive Decline, Vascular Cognitive Impairment
- Trial name
- NCT03545958
- Testing
- High-intensity Interval Training (HIT), Moderate-intensity Continuous Training (MCT)
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Western University, Canada
Postoperative Delirium, Postoperative Cognitive Dysfunction
Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- CogCheck-Valid (NCT03360838)
- Testing
- CogCheck
- Where
- Switzerland
- Volunteers
- 475 people
- Sponsor
- University Hospital, Basel, Switzerland
Mild Cognitive Impairment, Subjective Cognitive Decline
Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline
The goal of this clinical trial]is to evaluate if learning to play traditional board games could improve cognition in subjects with mild cognitive impairment and subjective cognitive decline.
- Trial name
- Cognichess (NCT06281652)
- Testing
- Go classes, Chess classes
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Milano Bicocca
Diabetes Mellitus, Type 2
Computerized Cognitive Training for Diabetic Elderly Veterans
Computerized cognitive training (CCT) is an intervention has improved cognitive functioning in the elderly with and without cognitive impairment.
- Trial name
- CCT_DEV (NCT01736124)
- Testing
- computerized cognitive training, control games
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- VA Office of Research and Development
Lacunar Stroke
A Multicenter Randomized Clinical Trial Compared With Standard Clinical Practice to Evaluate the Efficacy of a Polyphenol-rich Salicornia Extract in the Progression of Cognitive Decline in a Cohort of Patients With Lacunar Infarcts (SALACUNAR)
SALACUNAR (LACI-2-polyphenols) is a multi-center randomized controlled trial (RCT) to evaluate the effect of a polyphenol-rich supplement on small vessel neurovascular disease.
- Trial name
- SALACUNAR (NCT07353424)
- Testing
- B-salicornia
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Cancer, Prostate Cancer
Physicians' Health Study II
The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring.
- Conditions
- Cancer, Prostate Cancer, Colorectal Cancer, Cardiovascular Disease
- Trial name
- PHS II (NCT00270647)
- Testing
- Vitamin E, Vitamin C, Multivitamin
- Volunteers
- 14,641 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Life Style, Risk Reduction
The Effects of a Multidomain Lifestyle Intervention on Brain Functioning and Its Relation With Immunometabolic Markers in Ageing
HELI is a multicenter, randomised controlled trial in two Dutch research centres (Donders Centre for Cognitive Neuroimaging, Nijmegen, and the department of Human Nutrition \& Health at Wageningen University) among 104 older…
- Conditions
- Life Style, Risk Reduction, Cognitive Decline, Aging
- Trial name
- HELI (NCT05777863)
- Testing
- Multidomain lifestyle intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 102 people
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Postoperative Cognitive Dysfunction
Post Cardiac Surgery Neurocognitive Decline: Correlations Between Neuropsychological Tests and Functional MRI Techniques
Postoperative cognitive decline (POCD) is a frequent complication after cardiac surgery. It is estimated that 40-70% of all cardiac patients show cognitive dysfunction during the first post-surgical week.
- Trial name
- CardChNeuroMRI (NCT01622452)
- Volunteers
- 50 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
Silent Stroke
Association Between Gait Assessed by Intelligent System and Cognitive Function in Silent Cerebrovascular Disease
This study is a multi-center prospective cohort study. We will continuously recruit subjects with silent cerebrovascular disease aged 60 to 85 years from Shanghai and Guizhou.
- Trial name
- ACCURATE-2 (NCT04456348)
- Testing
- there is no intervention
- Volunteers
- 1,600 people
- Sponsor
- Shanghai Zhongshan Hospital