Clinical trials: Cognitive Function and Mental Health
Delirium, Post ICU Syndrome
Delirium Phenotypes and Subsequent Impairment During Transition From ICU to Hospital Wards
The goal of this observational study is to learn about the disability profile during transition from ICU to hospital wards of delirium patients, including cognitive impairment, physical dysfunction and psychological disorders.
- Trial name
- NCT07193797
- Testing
- Phenotypes of ICU delirium
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Shanghai Zhongshan Hospital
Sedentary Time, Insomnia
mPATH for Low-income Older Adults
Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults.
- Conditions
- Sedentary Time, Insomnia, Cognitive Decline
- Trial name
- NCT05935241
- Testing
- mPATH, Attention Control
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Illness, Cognitive Impairment
Home Care Medication Management Program for the Frail Elderly
The purpose of this study is to determine whether a home care medication management program which includes nurse coordination and use of the MD.2 medication-dispensing machine will affect older adults' health outcomes…
- Trial name
- NCT01321853
- Testing
- MD2 machine and nurse care coordination, Medplanner and Nurse Care Coordination
- Where
- United States
- Volunteers
- 414 people
- Sponsor
- Arizona State University
Schizophrenia, Schizoaffective Disorder
Cognitive Remediation Therapy Within a Secure Forensic Setting
This clinical trial tests the feasibility, effectiveness and patient satisfaction with cognitive remediation therapy for patients diagnosed with schizophrenia or schizoaffective disorder within a forensic hospital.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Cognitive Deficits
- Trial name
- NCT02360813
- Testing
- Cognitive Remediation Therapy, Treatment as usual
- Where
- Ireland
- Volunteers
- 65 people
- Sponsor
- Central Mental Hospital
Sleep Disorders, Frailty
Impact of Sleep Disorders and Digital Support on Older People's Health
The goal of this observational study is to learn about the effects of sleep disorders on health and ageing in older people over the age of 65.
- Conditions
- Sleep Disorders, Frailty, Cognitive Impairment, Quality of Life
- Trial name
- SOMNUS-DARE (NCT06944600)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Parma
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Alcohol Use Disorder, Alcohol Drinking
Virtual Incentive Treatment for Alcohol
The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention.
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
- Trial name
- VITA (NCT06265506)
- Testing
- Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington State University
Health, Subjective, Gastrointestinal Dysfunction
Personal Lifestyle Engine (PLX) - Personal Lifestyle Medicine Center (PLMC)
It has been suggested that the best medicine should include four principles (4P) - Medicine should be personalized, predictive, preventative and participatory.
- Conditions
- Health, Subjective, Gastrointestinal Dysfunction, Cardiovascular Risk Factor, Autoimmune Diseases
- Trial name
- NCT04007939
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Mental Disorders, Schizophrenia
A System for Preference Assessment in Mental Health
It is important that individuals with serious mental illness make informed choices among alternative healthcare treatments based on their preferences.
- Conditions
- Mental Disorders, Schizophrenia, Overweight, Obesity
- Trial name
- SPA (NCT02183844)
- Testing
- Psychosocial Weight Intervention
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of California, Los Angeles
Dementia, Mild Cognitive Impairment (MCI)
Augmented Reality-Based Aromatherapy Education for Older Adults With Early-Stage Dementia in Taiwan
This study evaluates an augmented reality (AR)-based aromatherapy education program designed for older adults with early-stage dementia in Taiwan.
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Neuropsychiatric Symptoms
- Trial name
- NCT07431164
- Testing
- Augmented Reality-Based Aromatherapy Education Program
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan Normal University
Schizophrenia, Cognition
Promoting Cognitive Health in Schizophrenia
The goal of this clinical trial is to effectively implement virtually-delivered interventions in mental health institutions nationwide to improve the cognitive health of individuals living with schizophrenia.
- Trial name
- iCogCA (NCT05661448)
- Testing
- Cognitive remediation, MetaCognitive Training
- Where
- 5 sites in Canada
- Volunteers
- 192 people
- Sponsor
- Douglas Mental Health University Institute
Mild Cognitive Impairment
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
This study is a randomized, single-blind, controlled trial that will test a multilevel intervention, Tiempo Juntos para la Salud, (Time Together for Health) designed to promote moderate-intensity physical activity; theoretically…
- Trial name
- NCT05030948
- Testing
- Tiempo Juntos Intervention
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Pennsylvania
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research
Age-related Cognitive Decline
Train the Brain With Music: Brain Plasticity and Cognitive Benefits Induced by Musical Practice in Elderly People
This longitudinal study aims to countervail age-related cognitive and cerebral decline in healthy retired people through intensive piano / keyboard music practice in Switzerland and Germany.
- Trial name
- TBM (NCT03674931)
- Testing
- musical practice, music education
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Cognitive Impairment, Healthy Control
Prediction of MMSE Scores for Cognitive Impairment
This study aims to explore the potential of using machine learning (ML) algorithms to predict cognitive status, specifically MMSE scores, based on oral health and demographic data.
- Trial name
- NCT06611475
- Testing
- MMSE ≤26
- Where
- Sweden
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Blekinge Institute of Technology
Obstructive Sleep Apnea, Sleep Disorder
Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy
This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy.
- Conditions
- Obstructive Sleep Apnea, Sleep Disorder, Well-Being, Psychological, Cognitive Impairment
- Trial name
- MULTI-OSAS (NCT06312956)
- Testing
- Continuous Positive Airway Pressure Ventilotherapy
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Istituto Auxologico Italiano
CKD Stage 4, CKD Stage 5
Frailty, Cognitive Function and Health-related Quality of Life in Older Adults With Advanced Chronic Kidney Disease.
This observational study explores the impact of cognitive impairment and frailty in older adults with advanced chronic kidney disease ].
- Conditions
- CKD Stage 4, CKD Stage 5, Frailty, Cognitive Impairment
- Trial name
- NCT05705011
- Where
- Romania
- Volunteers
- 240 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Treatment Adherence and Compliance, Anxiety
Global Controlled Trial on Effects of an Online Self-Help Program for of Ambitious Altruists on Their Mental Health, Wellbeing, and Productivity: Comparing Versions With IFS vs. CBT, Buddy- vs. Group-, Standard- vs. Minimum-Guidance Intensity.
This study aims to compare different versions of a 16-week online self-help program in terms of their effect on self-assessed mental health, well-being, and productivity.
- Conditions
- Treatment Adherence and Compliance, Anxiety, Depression, Mental Health Issue
- Trial name
- CT_DoBetter (NCT06442072)
- Testing
- guided online self-help program
- Where
- Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rethink Wellbeing
Chronic Inflammation, Chronic Pain
Gulf War Illness Inflammation Reduction Trial
The primary objective of this clinical trial is to determine if treatment with an anti-inflammatory drug (delayed-release prednisone) improves the health-related quality of life (HRQOL) of veterans with Gulf War Illness (GWI).
- Conditions
- Chronic Inflammation, Chronic Pain, Fatigue, Cognitive Impairment
- Trial name
- GWIIRT (NCT02506192)
- Testing
- Modified-Release Prednisone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Schizophrenia
Efficacy of ISST in Schizophrenia
The ISST study investigates whether integrated social cognitive remediation and social behavioral skills therapy is more efficacious in improving functional outcome and treatment adherence than an active control treatment…
- Trial name
- NCT02678858
- Testing
- Integrated Social Cognitive and Behavioral Skills Therapy, Neurocognitive Remediation Therapy
- Where
- 6 sites in Germany
- Volunteers
- 177 people
- Sponsor
- Heinrich-Heine University, Duesseldorf