Clinical trials: Cognitive Function and Mental Health
Brain Injuries, Cognitive Impairment
Occupational Therapy and Cognitive Challenges After Brain Injury
Background: There is a need for standardized interventions in community rehabilitation that can improve everyday task performance for older adults with cognitive challenges after acquired brain injury.
- Trial name
- NCT05148247
- Testing
- The Perceive, Recall, Plan and Perform System of Intervention
- Where
- 2 sites in Norway
- Volunteers
- 6 people
- Sponsor
- Norwegian University of Science and Technology
Mental Health, Cognition
Bio-Experiential Spaces for Mental Health in Healthworkers
Recharge Rooms are immersive, biophilic private spaces designed to ameliorate trauma, anxiety, and stress. They feature multisensory input that is inspired by nature, as has previously been found to confer physiological benefits.
- Conditions
- Mental Health, Cognition, Anxiety
- Trial name
- NCT05227352
- Testing
- Biophilic design experience
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post Traumatic Stress, Overall Functioning
Randomized Controlled Trial of Supervision Strategies to Improve Clinician Fidelity to Trauma-focused CBT
The primary goal of this study is to examine the impact of varying supervision strategies on clinician fidelity and client outcomes in a community-based setting.
- Conditions
- Post Traumatic Stress, Overall Functioning, Clinician Fidelity, Supervision
- Trial name
- STEPS (NCT01800266)
- Testing
- Supervision Practices of TF-CBT
- Where
- United States
- Volunteers
- 1,280 people
- Sponsor
- University of Washington
Alzheimer Disease
Effect of Physical Exercise in Alzheimer Patients
Background: Current treatment for Alzheimer's disease (AD) is symptomatic and can only temporarily slow down progression. Exercise has the potential to improve cognition, psychological symptoms, physical performance and quality…
- Trial name
- ADEX (NCT01681602)
- Testing
- Aerobic exercise
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mental Health, Cognition
Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly
The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints.
- Conditions
- Mental Health, Cognition, Memory, Attention
- Trial name
- NCT01427231
- Testing
- glucose, sacharose
- Where
- Netherlands
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Cognitive Decline, Vascular Health
Double-task Exercise in Older Adults at Risk of Cognitive Decline (MeMo-Health-Cog-3 Program)
Cerebral small vessel disease is a frequent cause of cognitive disability among older adults (OAs) in Mexico that imposes a significant burden on the health system and OAs' families.
- Trial name
- NCT04068376
- Testing
- Control excercise, "Mind and Movement for Cognitive Health in the Older Adult", Double-task exercise by older adults and their caregivers
- Where
- Mexico
- Volunteers
- 300 people
- Sponsor
- Instituto Mexicano del Seguro Social
Alzheimer Disease, Mild Cognitive Impairment
A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
The purpose of this study is to learn about health care use, costs, and clinical outcomes over time for amyloid positive participants with early stages of AD in the United States.
- Trial name
- GERAS-US (NCT02951598)
- Testing
- Florbetapir F 18 PET Scan
- Where
- 77 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- Eli Lilly and Company
Mild Cognitive Impairment, Aged
South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention
This study evaluates acceptability and efficacy of multidomain intervention program to prevent cognitive impairment and protect brain health in Korean at-risk elderly.
- Trial name
- SUPERBRAIN (NCT03980392)
- Testing
- Multidomain intervention program
- Where
- 6 sites in South Korea
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Inha University Hospital
Mild Cognitive Impairment, Caregiver Burden
A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI
This clinical trial is being conducted to see if brain stimulation and brain training together improves cognitive functioning and mood in older adults diagnosed with Mild Cognitive Impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Caregiver Burden, Mental Health Issue, ADL
- Trial name
- rTMS+iVCT (NCT06024473)
- Testing
- rTMS, rTMS+iVCT
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Central Arkansas Veterans Healthcare System
Cognitive Impairment, Mild, Dementia, Mild
Buddy-Up Dyadic Physical Activity Program for Persons With Dementia and Family Caregivers
The global cost of dementia is over 818 billion, and a further rise is expected in the next decade. While family caregiving is the backbone of the formal care service, promoting "living well with dementia" needs to extend to a…
- Conditions
- Cognitive Impairment, Mild, Dementia, Mild, Dementia, Caregiver Burden
- Trial name
- BUDPA (NCT06584110)
- Testing
- Buddy-Up Dyadic Physical Activity (BUDPA) program, Usual care with waitlist control
- Where
- Hong Kong
- Volunteers
- 236 people
- Sponsor
- The University of Hong Kong
Diabetes Type 2, Diabetes Type 1
Disentangling the Effect of Brain Insulin Resistance on Brain Health
People with diabetes are at increased risk of developing dementia, including Alzheimer's disease and vascular dementia. In addition, persons with diabetes have more pronounced age-related brain atrophy and cognitive difficulties…
- Trial name
- BIR 1 (NCT07374705)
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henrik Bo Wiberg Larsson
Quality of Life, Cognitive Decline
Health and Energy Through Active Living Every Day After Cancer Intervention for Cancer Survivors
The purpose of the Health and Energy through Active Living Every Day (HEALED) intervention, is to examine the effect of a web-based intervention on changes in device-measured physical activity (light and moderate-to-vigorous…
- Conditions
- Quality of Life, Cognitive Decline, Fatigue, Sleep
- Trial name
- HEALED (NCT05356988)
- Testing
- Physical activity experiment, Balance and flexibility control
- Where
- United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- American Cancer Society, Inc.
Dementia
Enhancing Mobility and Mental Health in Dementia Patients
This study aims to evaluate the effect of a multidisciplinary six-minute walking group and activities on patients with dementia\'s physical activity levels, mobility, anxiety, and cognitive function.
- Trial name
- NCT06611202
- Testing
- Exercise, Clonazepam
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Oxleas NHS Foundation Trust
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Breast Cancer, Breast Neoplasms
Mental and Cognitive Health and Physical Activity in the Perioperative Breast Cancer Setting
This study evaluates the complex relationships between mental health, cognitive function, and physical activity before surgery in patients with stage I-III breast cancer.
- Conditions
- Breast Cancer, Breast Neoplasms, Cancer, Breast, Cancer of the Breast
- Trial name
- NCT06595901
- Testing
- Actigraph, Questionnaires, BrainBaseline application
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes Mellitus (T2DM), Cognitive Impairment
Exercise and PPARGC1A rs8192678 in Older Adults With Type 2 Diabetes and Cognitive Impairment
This completed single-arm interventional study evaluated changes in metabolic control, cognitive function, and health-related physical fitness following a 12-week combined aerobic and resistance exercise program in older adults…
- Trial name
- Association Be (NCT07711834)
- Testing
- Combined aerobic and resistance exercise
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Harbin Sport University
Cognitive Change, Well-Being, Psychological
Trout Consumption in Young Children and Families and Brain Health
Regular fish consumption may support brain health. Trout lines developed in Idaho contain higher levels of omega-3 fatty acids, nutrients important for human cognition and mental wellbeing.
- Trial name
- NCT06721468
- Testing
- Trout, Child-centered nutrition phrases, Puzzle
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Idaho
Menopause, Cognitive Dysfunction
Brain Fog and Life Quality in Menopause
This clinical study aims to investigate cognitive changes in women undergoing the menopausal transition, with a specific focus on the prevalence, characteristics, and impact of brain fog.
- Conditions
- Menopause, Cognitive Dysfunction, Memory Disorders, Quality of Life
- Trial name
- NCT06978218
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Merve Coskun
Sleep Health, Stress
Sleep Well Firefighters: An App-based Program to Improve Sleep, Cognition, and Behavioral Health in Firefighters
The purpose of this pilot study is to examine the feasibility and acceptability of an app-based sleep program designed to help firefighters improve their sleep.
- Conditions
- Sleep Health, Stress, Anxiety, Physical Activity
- Trial name
- NCT07477184
- Testing
- Sleep enhancement intervention, Standard of Care (Investigator Choice)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Type2 Diabetes, Type 2 Diabetes Mellitus in Obese
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus in Obese, Dysglycemia, Microvascular Complications
- Trial name
- Metabrain (NCT05277558)
- Testing
- Observational
- Where
- 2 sites in United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine