Clinical trials: Cognitive Health, open to volunteers
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Chronic Migraine, Headache
Comprehensive Approach to Lifestyle Modification in Chronic Migraine
Migraine is a highly prevalent neurological disorder and one of the leading causes of disability worldwide, substantially affecting quality of life and individuals during their most productive years.
- Trial name
- CALM-Migraine (NCT07802860)
- Testing
- Comprehensive Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Mild Cognitive Impairment (MCI)
Exercises for Rehabilitation of COgnition and Lifestyle Enhancement in Patients With Mild Cognitive Impairment
Mild Cognitive Impairment (MCI) is a clinical condition with a heterogeneous etiology and clinical course characterized by objective cognitive deficits not severe enough to cause clear functional limitations or to warrant a…
- Trial name
- ERCOLE (NCT07517380)
- Testing
- Multimodal Group Cognitive Rehabilitation Intervention, Active Control
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Casa di Cura IGEA
Psychosocial Well-being, Neurocognitive Function
taVNS + CCT for Neurocognitive Rehab
The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood.
- Conditions
- Psychosocial Well-being, Neurocognitive Function, Cognitive Complaint, Cognitive Dysfunction
- Trial name
- NeuroHUB (NCT07517237)
- Testing
- taVNS, Computerized Cognitive Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
HIV -1 Infection, Mental Health Issue
Integrating iSYV Within HIV Clinical Care for Youth Living With HIV in Tanzania
Youth living with HIV (YLWH) experience mental health (MH) challenges that compromise their HIV care. Though the MH gap is well described, MH service delivery to YLWH is rare, especially in low resource settings.
- Trial name
- NCT07621510
- Testing
- iSYV (integrated Sauti ya Vijana; The Voice of Youth), mHealth, eSOC
- Where
- Tanzania
- Volunteers
- 5,000 people
- Sponsor
- Duke University
Urinary Incontinence (UI), Lower Urinary Tract Symptoms (LUTS)
Reducing Disparities in Urinary Control Symptoms for Minority Women
The study is designed to address the disparity in available conservative/behavioral treatments for UI/LUTS. The program was developed by experts from urogynecology, psychology, and physical therapy then modified based on focus…
- Conditions
- Urinary Incontinence (UI), Lower Urinary Tract Symptoms (LUTS), Pelvic Floor Disorder
- Trial name
- SUPPORT (NCT06798311)
- Testing
- SUPPORT workbook
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
LTC-to-hospital Transfer Decision-making
Evaluation of the STEP Intervention for Long-Term Care Residents Facing Hospital Transfer Decisions
This trial will evaluate whether the Supporting Transitions and Empowering Preferences (STEP) toolkit can improve decision-making about hospital transfers in long-term care residents and their substitute decision-makers and…
- Trial name
- STEP (NCT07153341)
- Testing
- STEP Decision Support Toolkit
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Bruyère Health Research Institute.
Mild Cognitive Impairment (MCI), Older People
Digital Health and Exercise for Autonomous Longevity Program
Digital HEAL (Health and Exercise for Autonomous Longevity) is a multicomponent training program (combining concurrent training with cognitive stimulation) designed to promote physical fitness and cognitive function in older…
- Trial name
- DigitalHEAL (NCT06722976)
- Testing
- Multicomponent exercise programs
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Aging
Breaking Sitting with High-intensity Interval Training for Brain Health
This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in…
- Trial name
- HIIT2SITLess (NCT06243016)
- Testing
- High-Intensity Interval Training (HIIT) Breaks to Sitting, Light-Intensity Interval Training (LIIT) Breaks to Sitting
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Tobacco Use Disorder
Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily
This study aims to test the feasibility and acceptability of a remotely delivered cue-based treatment intervention to promote smoking cessation among people who smoke lightly or non-daily.
- Trial name
- NCT07425119
- Testing
- Cognitive Behavioral Therapy (CBT), Cue-based treatment intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Anxiety, Depression
eBehandling - Health and Work for Patients in Specialist Mental Health Care
Mental health problems and disorders affect one in every five amongst the working- age adults in the countries of the Organization for Economic Cooperation and Development.
- Trial name
- NCT06568419
- Testing
- Transdiagnostic, work-focused Cognitive Behavioural Therapy
- Where
- 9 sites in Norway
- Volunteers
- 400 people
- Sponsor
- Solli Distriktspsykiatriske Senter
Suicide Attempt
Treating Suicidality Remotely
Background: Practical and psychological barriers make it difficult for people with Suicidal Thoughts and Behaviors (STBs) to get professional help.
- Trial name
- TREASURE (NCT06370104)
- Testing
- Brief Cognitive Behavioral Therapy for Suicide Prevention, Living under control
- Where
- Netherlands
- Volunteers
- 364 people
- Sponsor
- 113 Suicide Prevention
Brain Fog, Cognitive Health
Modulation of the Brain Fog Scale by Eicosapentaenoic Acid Monoglycerides (MAG-EPA).
A growing body of studies shows that omega-3s act directly in molecular signaling pathways that reduce inflammation and are thought to have a positive effect on cognitive health.
- Trial name
- NBF-MG01 (NCT06695910)
- Testing
- Monoglyceride Eicosapentaenoic acid (omega-3), Sunflower Oil
- Where
- 2 sites in Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Samuel Fortin
Mild Cognitive Impairment
WAVE: AudioVisual Stimulation Enhances Cognitive, Mental and Physical Health in Elderly
The goal of this randomized controlled trial is to 1) carry out a screening of cognitive function, depressive symptoms, agility and functional balance and chronic inflammatory conditions in older adults; 2) analyze the influence…
- Trial name
- NCT06686563
- Testing
- Intervention Group: Gamma stimulation, Control Group: Theta stimulation
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maria Paço
Serious Mental Illness, Older Adults
A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program
The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle…
- Trial name
- (HHL) (NCT06940843)
- Testing
- Hopeful and Healthy Living (HHL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Subjective Cognitive Decline (SCD)
PENSA+: Extended Follow-up of a Multimodal Lifestyle Intervention to Prevent Cognitive Decline in APOE-ε4 Carriers
PENSA+ is a 5-year follow-up study of participants who previously completed the PENSA clinical trial (NCT03978052), which evaluated an intensive multimodal lifestyle intervention, with or without epigallocatechin gallate (EGCG)…
- Trial name
- PENSA+ (NCT07730671)
- Where
- Spain
- Volunteers
- 121 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Cardiovascular Diseases, Cognition
Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health
In a single-blind, randomised, placebo-controlled crossover manner, this study aims to assess the impact of a high-fat mixed meal containing a whey protein (WP)-enriched milk fat globule membrane (MFGM) powdered ingredient on…
- Conditions
- Cardiovascular Diseases, Cognition, Overweight or Obesity, Postmenopausal Women
- Trial name
- NCT06953232
- Testing
- Whey protein-enriched milk fat globule membrane supplement, Whey protein-based supplement
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Autism Spectrum Disorder, PTSD and Trauma-related Symptoms
TF-CBT for Autistic Youth Pilot Implementation - Open Pilot
Compared to the general population, autistic youth are at increased risk for both exposure to potentially traumatic events and trauma-related symptoms following trauma exposure.
- Conditions
- Autism Spectrum Disorder, PTSD and Trauma-related Symptoms, Autism, Trauma and Stressor Related Disorders
- Trial name
- NCT07420478
- Testing
- Trauma-Focused Cognitive Behavioral Therapy, modified for autistic youth
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Loneliness, Depression
Enhancing Internet-Delivered Cognitive Behaviour Therapy With Additional Content
This study evaluates the effectiveness of additional content on loneliness offered alongside the Wellbeing Course - an internet-delivered cognitive behavioral therapy (ICBT) intervention for symptoms of depression and anxiety- in…
- Conditions
- Loneliness, Depression, Anxiety
- Trial name
- NCT07095582
- Testing
- Internet-delivered cognitive behavioral therapy, Additional Loneliness Content
- Where
- 2 sites in Canada
- Volunteers
- 494 people
- Sponsor
- University of Regina
Omega-3 Deficiency, DHA and EPA Blood Levels
A Clinical Trial to Evaluate the Effects of an Omega-3-containing Supplement on DHA and EPA Levels in the Blood
This is a 12-week, hybrid, single-arm clinical trial designed to evaluate the effects of an omega-3-containing supplement (Omega Active) on DHA and EPA levels in the blood.
- Conditions
- Omega-3 Deficiency, DHA and EPA Blood Levels, Cardiovascular Health, Cognitive Health
- Trial name
- NCT07753174
- Testing
- Omega Active Supplement
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Revive Active