Clinical trials: Cognitive Impairment, Mild
Mild Cognitive Impairment (MCI)
Cognitive-Frailty Gait Biomechanics for Early Dementia Detection
The purpose of this study is to better understand how physical characteristics, walking patterns, and a blood-based brain health marker differ between older adults with dementia and healthy older adults.
- Trial name
- gait dementia (NCT07448909)
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alzheimer Dementia
Allopregnanolone Regenerative Therapeutic for Early Alzheimer's Disease: Intramuscular Study
The purpose of this study is to identifying the intramuscular dose equivalent to the 4mg intravenous dose and assess its safety and tolerability as a weekly injection.
- Trial name
- Allo-IM (NCT03748303)
- Testing
- Allopregnanolone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Arizona
Glaucoma, Mild Cognitive Impairment
Assessing Neurovisual Function in Patients With Cognitive Impairment
The aim of this study is to measure fitness to drive in patients with a visual and a cognitive impairment. To do so, Ocusweep is used in patients with glaucoma and Mild Cognitive Impairment.
- Conditions
- Glaucoma, Mild Cognitive Impairment, Glaucoma and Mild Cognitive Impairment, Healthy
- Trial name
- NCT03333096
- Testing
- Ocusweep test battery, Neuropsychological test battery
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Dementia, Mild Cognitive Impairment
An Intervention to Reduce Discrepancy in Everyday Preferences
Dementia is a disabling, progressive major neurocognitive disorder. Although cognitive symptoms drive the diagnosis of dementia, neuropsychiatric symptoms (NPS), such as depression, agitation/aggression, and psychosis, are common…
- Trial name
- NCT03577418
- Testing
- Templated, clinician-facilitated intervention to align everyday living preferences assessment
- Where
- United States
- Sponsor
- Mclean Hospital
Alzheimer Disease
A Study of CM383 in Patients With Alzheimer's Disease Related Mild Cognitive Impairment and Mild Alzheimer's Disease
This is a randomized, double-blind, placebo-controlled and multiple dose escalation phase Ib study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of CM383 in patients with Alzheimer's…
- Trial name
- NCT06619613
- Testing
- Alzheimer Disease (AD)
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Keymed Biosciences Co.Ltd
Mild Cognitive Impairment (MCI)
Multicomponent Intervention to Improve Cognitive Abilities in Older Adults With Mild Cognitive Impairment
The research aims to investigate the effectiveness of a new short-term multicomponent intervention to promote the bio-psycho-social-spiritual health of older adults with MCI to improve their cognitive abilities.
- Trial name
- MMI for MCI (NCT07549074)
- Testing
- Cognitive stimulation, Lifestyle Education, Multicomponent intervention
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong
Memory Disorders
Efficacy and Safety of Piracetam Taken for 12 Months in Subjects Suffering From Mild Cognitive Impairment (MCI)
The purpose of this study was to explore in a more documented way the relative potential and efficacy of piracetam 9600 and 4800 mg daily.
- Trial name
- NCT00567060
- Testing
- Piracetam
- Volunteers
- 676 people
- Sponsor
- UCB Pharma
Mild Cognitive Impairment
Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment
This randomized controlled trial aims to evaluate the effectiveness of Tai Chi and conventional exercise on improving cognitive function in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT05540613
- Testing
- Health Education, Conventional Exercise, Tai Chi
- Where
- Hong Kong
- Volunteers
- 315 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment
Effects of Combined Physical-cognitive Training on Cognitive Function in MCI
The present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI.
- Trial name
- NCT03805620
- Testing
- Combined physical-cognitive training, Physical training, Cognitive training
- Where
- Thailand
- Volunteers
- 128 people
- Sponsor
- Chiang Mai University
Mild Cognitive Impairment, Alzheimer Disease
Music Therapy for Patients With Alzheimer's Disease
This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or…
- Trial name
- NCT05151562
- Testing
- Virtual Music Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment (MCI), Cognitive Training
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial
Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia.
- Trial name
- COGIT-2 (NCT06601933)
- Testing
- Cognitive Training
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Columbia University
Dementia, Mild, Mild Cognitive Impairment
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
The purpose of this study is to test the adapted protocol, CAPABLE Family which builds upon the evidenced based CAPABLE program to address older adults with co-occurring physical disability and mild cognitive impairment or early…
- Conditions
- Dementia, Mild, Mild Cognitive Impairment, Disability Physical, Impairment, Cognitive
- Trial name
- NCT05187117
- Testing
- CAPABLE Family - Open Label Pilot, CAPABLE Family - Randomized Control Trial
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Diabetic Neuropathy, Balance
Effects of Turning Based Dual Task Training on Balance and Mild Cognitive Impairment in Diabetic Peripheral Neuropathy
Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, characterized by impaired sensory and motor function, often leading to balance dysfunction and an increased risk of falls.
- Conditions
- Diabetic Neuropathy, Balance, Cognitive Dysfunction, Cognitive Decline
- Trial name
- NCT07394504
- Testing
- Turning Based Dual Task Training, Dual-Task Training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Foundation University Islamabad
Mild Cognitive Impairment, Alzheimers Disease
Multiple Nutritional Deficiencies Causing Dementia of the Alzheimer Type
The purpose of the study is to compare the concentrations of Vitamin B1 (thiamine), Vitamin B6 (pyridoxal-5-phosphate), folate, Vitamin B12 (cobalamin), Vitamin C (ascorbic acid), Vitamin A (retinol), Vitamin E (alfa-tocopherol)…
- Trial name
- ALZ-vit (NCT01479855)
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Survivorship, Quality of Life
Neuromodulation of Central Sensory Integration to Improve Postural Control
The objective is to evaluate if neuromodulation of the PFC can acutely improve sensory integration for balance performance in OTTBCS.
- Conditions
- Survivorship, Quality of Life, Cognitive Deficits, Mild
- Trial name
- NCT06610617
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI)
A Study of QLH2405 in Healthy Participants and Participants With Mild Cognitive Impairment Due to Alzheimer's Disease and Mild Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of QLH2405 injection in healthy participants and participants with mild cognitive impairment (MCI) due to…
- Trial name
- NCT07489599
- Testing
- QLH2405
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Mild Cognitive Impairment
Cognitive Stimulation Therapy and Olderly People With Mild Cognitive Impairment
The aim of this study is to examine the effect of cognitive stimulation therapy on cognitive status and apathy in elderly individuals with mild cognitive impairment.
- Trial name
- NCT06115785
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ejdane Coskun
Mild Cognitive Impairment, Subjective Cognitive Decline
Efficacy of a Multicomponent Cognitive Intervention in Adults With Subjective Cognitive Decline and Mild Cognitive Impairments
Individuals with mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have greater risk of developing dementia.
- Trial name
- NCT04023032
- Testing
- multicomponent cognitive intervention
- Where
- Taiwan
- Volunteers
- 28 people
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment, Adults
Comparative Effects of a2 Skim Milk on Mild Cognitive Impairment in Older Adults
The aim of the study is to compare the effects of powdered skim milk containing A2 β-casein only versus conventional powdered skim milk containing A1 and A2 β-casein milk on cognition, inflammation, and dietary intake in adults…
- Trial name
- NCT05741047
- Testing
- a2Milk skim milk powder, Yili skim milk powder
- Where
- 2 sites in China
- Volunteers
- 96 people
- Sponsor
- a2 Milk Company Ltd.