Clinical trials: Cognitive Investigation
Parkinson Disease, Parkinson Disease, Mild Cognitive Impairment
Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation
The study aims to investigate neural correlate of Mild Cognitive Impairment (MCI) in Parkinson's disease (PD) and to identify a link between functional impairment (in both cognitive and motor domains) and electrophysiological…
- Conditions
- Parkinson Disease, Parkinson Disease, Mild Cognitive Impairment, Healthy
- Trial name
- MMCI (NCT06640673)
- Testing
- Hd-EEG
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (NMI)
The proposed study is designed to evaluate the performance of the ALTOIDA™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Memory Disorders, Cognitive Impairment
- Trial name
- AltoidaML (NCT02843529)
- Testing
- Altoida: neuropsychological, MRI, EEG and CSF biomarkers
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Altoida
Fibromyalgia
Cognitive Dysfunction in Fibromyalgia Patients
Fibromyalgia is a common rheumatologic disorder. Many patients complain of cognitive dysfunction as part of their symptoms. The investigators aim to assess this cognitive dysfunction through extensive neuro-cognitive testing.
- Trial name
- NCT01655537
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Hadassah Medical Organization
Postoperative Cognitive Dysfunction
Optic Nerve Sheath Diameter and Cognitive Outcomes in Bentall Surgery
Bentall surgery is a major cardiac procedure involving replacement of the ascending aorta, aortic root, and aortic valve, typically requiring cardiopulmonary bypass (CPB) and sometimes deep hypothermic circulatory arrest (DHCA).
- Trial name
- ONCOB (NCT07452367)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Anxiety Disorders
An Investigation of General Predictors for CBT Outcome for Anxiety Disorders in a Naturalistic Setting
The aim of this study is to investigate the predictive value of emotion regulation and attentional control for outcome of Cognitive Behavioural Therapy for adults with anxiety disorders in a naturalistic setting.
- Trial name
- NCT02638363
- Testing
- Cognitive behavioral therapy
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Copenhagen
Sepsis
Electroencephalographic Patterns of Septic Patients and Its Correlation With Cognitive Outcomes
The investigators evaluated the electroencephalographic pattern by the Sinek and Young scales during ICU stay and its correlation with cognitive impairment determined by the Montreal Cognitive Assessment (MOCA) in septic patients…
- Trial name
- NCT05448534
- Testing
- Eletroencephalography
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Hospital Sao Domingos
Transcranial Direct Current Stimulation, Functional Magnetic Resonance Imaging
High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease
This completed randomized trial evaluated the clinical and neural effects of high-definition transcranial direct current stimulation (HD-tDCS) combined with computerized cognitive training in patients with Alzheimer's disease.
- Conditions
- Transcranial Direct Current Stimulation, Functional Magnetic Resonance Imaging, Early Alzheimer's Disease
- Trial name
- HD-tDCS (NCT04599764)
- Testing
- HD-tDCS, computer-based cognitive training, Control cognitive training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Mild Cognitive Impairment
Management of Mild Cognitive Impairment Patients With Greek Mountain Tea - TEAMENTIA
There is accumulating evidence suggesting that Greek Mountain Tea may have a positive impact on conditions involving cognitive deficits, such as Mild Cognitive Impairment (MCI) and AD.
- Trial name
- TEAMENTIA (NCT04435509)
- Testing
- 1000+ Greek Mountain Tea, Mediterranean Diet
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
EEG and TMS-based Biomarkers of ALS, MS and FTD
The purpose of this observational study is to improve understanding of the biology of why ALS, MS and FTD have different effects on different people and facilitate better measurement of the disease in future drug testing.
- Conditions
- Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Multiple Sclerosis
- Trial name
- NCT04918251
- Testing
- 128 electrode electroencephalography (EEG), Transcranial magnetic stimulation (TMS)
- Where
- Ireland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Parkinson Disease, Mild Cognitive Impairment
Adaptango Performance PRocess for Older Adults Community reHabilitation
This study is being done to answer the question: How do people with Parkinson's disease, people with Mild Cognitive Impairment, and younger people process difficult topics in conversation? It will also explore themes related to…
- Conditions
- Parkinson Disease, Mild Cognitive Impairment, Old Age; Dementia
- Trial name
- APPROACH (NCT07824128)
- Testing
- Adaptango Performance Process (APP) program
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Autism Spectrum Disorder, Social Communication Disorder
Safety and Efficacy of NDTx-03 in Children and Adolescents With ASD or SCD
The purpose of this study is to evaluate the safety of NDTx-03 used together with treatment as usual (TAU) and to determine whether NDTx-03 plus TAU is more effective than TAU alone in improving social situation recognition and…
- Trial name
- NCT07770867
- Testing
- NDTx-03, TAU
- Where
- 7 sites in South Korea
- Volunteers
- 156 people
- Sponsor
- Neudive Inc.
Pulmonary Fibrosis, Anxiety
Controlled Investigation to Evaluate Impact of dCBT on Psychological Symptom Burden in Adult Subjects With PF
The purpose of the study is to assess efficacy and safety of a digital cognitive behavioural therapy for patients with pulmonary fibrosis on anxiety.
- Trial name
- COMPANION (NCT05330312)
- Testing
- Digital cognitive behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- Vicore Pharma AB
Post-stroke Cognitive Impairment
Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Post-stroke Cognitive Impairment
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of post-stroke cognitive impairment patients' cognitive function by altering the cortical…
- Trial name
- NCT03647319
- Testing
- High-frequency rTMS on left DLPFC+anodal tDCS on right DLPFC, High-frequency rTMS on left DLPFC+cathodal tDCS on right DLPFC
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center
Traumatic Brain Injury, Diffuse Axonal Injury
Brain Stimulation for Traumatic Brain Injury
The purpose of this study is to determine whether repetitive Transcranial Magnetic Stimulation (rTMS) is effective in the cognitive rehabilitation of patients with diffuse axonal injury(DAI) after Traumatic Brain Injury(TBI).
- Trial name
- TMS/DAI (NCT02167971)
- Testing
- Active Coil
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Minor Stroke
Early-phase Telecare Programs for Minor Stroke
Minor strokes (few acute neurological symptoms ; NIHSS score <5), represent almost 65% of cerebrovascular ischemic events. The increasing incidence of stroke in people under 65, together with advances in diagnostic and…
- Trial name
- COGaDOM (NCT06306144)
- Testing
- Psychoeducation, Computerised Cognitive Stimulation, Usual Care
- Where
- 3 sites in France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Cognitive Function
Investigation of Acute Mood and Cognitive Performance Effects of Beverages Containing Phenolics in Healthy Adults
An acute, randomized, placebo controlled, double blinded crossover study in health subjects. Participants will complete 4 intervention arms in random order consisting of a placebo control beverage, a high dose phenolic beverage…
- Trial name
- NCT02675621
- Testing
- Phenolic Beverage
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Alzheimer Disease, Dementia, Alzheimer Type
Dose-Finding Study To Evaluate Safety, Tolerability, and Efficacy of E2609 in Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (Prodromal Alzheimer's Disease) and Mild to Moderate Dementia Due to Alzheimer's Disease
This is a Phase 2 study to evaluate safety and efficacy in participants with Mild Cognitive Impairment due to Alzheimer's Disease/Prodromal Alzheimer's Disease (referred to as MCI/Prodromal) and mild to moderate dementia due to…
- Trial name
- NCT02322021
- Testing
- E2609
- Where
- 21 sites in United States
- Volunteers
- 70 people
- Sponsor
- Eisai Inc.
Dementia
Nurse-led Medicines' Monitoring in Care Homes: a Process Evaluation
Lay Summary: The investigators have shown in randomised controlled trials and observation studies that structured nurse-led medicines' monitoring using the WWADR Profile benefits patients, for example, by reducing pain and…
- Trial name
- NCT03110471
- Testing
- West Wales Adverse Drug Reaction (WWADR) Profile, usual care
- Where
- 10 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Swansea University
Dyslipidemias
Are Exercise Capacity and Physical Fitness Related With Quality of Life, Physical Activity, Cognitive Health and Health Literacy in Dyslipidemia
There is insufficient literature explaining the relationship between exercise capacity and physical fitness of dyslipidemia patients and quality of life, cognitive status and health literacy.
- Trial name
- NCT06563154
- Testing
- Exercise Capacity Assessment, Physical Fitness Assessment, Quality of Life Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Çankırı Karatekin University
Primary Brain Tumor, Neurocognition
Executive and Socio-cognitive Functions in Survivors of Primary Brain Tumor: Impact on Patients' Quality of Life
Significant advances in primary malignant brain tumors (PBT) treatment have led to dramatically improved survival, both in children and adults.
- Conditions
- Primary Brain Tumor, Neurocognition, Quality of Life
- Trial name
- NEUROCOG-QOL (NCT02693405)
- Testing
- Executive functions, social cognition, quality of life
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
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