Clinical trials: Cognitive Investigation
Healthy
Pilot Study to Evaluate the Duration of Effects on Simulated Car Driving and Cognitive Performance After a Single Dose of JNJ-42847922, Zolpidem and Placebo in Healthy Participants
The purpose of the study is to evaluate the effects of JNJ-42847922, compared to zolpidem and placebo, on driving performance as assessed by the mean difference of standard deviation of lateral position (SDLP) after forced…
- Trial name
- NCT02578472
- Testing
- JNJ-42847922, Zolpidem
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Janssen-Cilag International NV
Cognitive Change, Beta-Thalassemia
Assessment of Cognitive Function, Fatigue and Health Related Quality of Life in Children With Beta Thalassemia
This study aims to: Assess the cognitive function in children with beta thalassemia Evaluate the fatigue in beta thalassemic children Assess the health related quality of life measures in children with beta thalassemia.
- Conditions
- Cognitive Change, Beta-Thalassemia, Fatigue, Quality of Life
- Trial name
- NCT05469230
- Where
- Egypt
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Cairo University
Memory Disorders, Alzheimer Disease
Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGNISION™) as a Useful Cognitive Biomarker for Alzheimer's Disease.
The proposed study is designed to evaluate the performance of the COGNISION™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Memory Disorders, Alzheimer Disease, Dementia, Cognitive Impairment
- Trial name
- COGNISION™ (NCT00938665)
- Testing
- COGNISION™ System
- Where
- 7 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Neuronetrix, Inc.
Healthy Aging, Mobility Limitation
Power Centering for Seniors
Walking difficulties, mobility decline and falls are prevalent among older adults. The incidence of each of these increases with age and the presence of each can negatively affect the quality of life in older adults.
- Conditions
- Healthy Aging, Mobility Limitation, Walking, Difficulty
- Trial name
- PCS (NCT04861831)
- Testing
- Power Centering for Seniors intervention
- Where
- Switzerland
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Department of Geriatric Medicine FELIX PLATTER
Driving Habits Patients, Cognitive Impairment
Evaluation of an Educational Program in the Prevention of the Driving Risks in Patients With Neurocognitive Disorders : ACCOMPAGNE
ACCOMPAGNE study proposes to evaluate an educational program for the patient / caregiver dyad, intended to accompany the patient towards the implementation of self-regulation strategies in the driving activity.
- Trial name
- ACCOMPAGNE (NCT04493957)
- Testing
- ACCOMPAGNE Education Program, Usuals recommandations
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Chronic Low Back Pain
Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response
VETERANS ONLY. Chronic low back pain (cLBP) is common. Most Americans will have at least one episode of low back pain in their lifetimes.
- Trial name
- SCEPTER (NCT04142177)
- Testing
- Pain EASE, Tailored exercise, Continued Care and Active Monitoring
- Where
- 19 sites in United States
- Volunteers
- 2,529 people
- Sponsor
- VA Office of Research and Development
Tic Disorder, Chronic Motor or Vocal, Tourette Syndrome in Children
Evaluation of a Cognitive Psychophysiological Treatment for Tourette Syndrome and Tic Disorders
It is a randomized controlled trial to compare two behavioural treatments, namely CBIT and CoPs. This study would be the first head-to-head randomized trial between two established treatments rather than supportive counseling or…
- Conditions
- Tic Disorder, Chronic Motor or Vocal, Tourette Syndrome in Children, Tourette Syndrome
- Trial name
- NCT03225430
- Testing
- Cognitive behavioural treatment for tics, Cognitive psychophysiological
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Cardiovascular Disease, Aortic Valve Stenosis
Evaluating the Risk of Cognitive Impairment After Surgical and Transcatheter Aortic Valve Replacement
The investigators are conducting a pilot study to compare cognitive outcomes among Veterans with severe aortic valve stenosis who are scheduled to undergo either aortic valve replacement.
- Conditions
- Cardiovascular Disease, Aortic Valve Stenosis, Cognitive Assessments, Valve Surgery
- Trial name
- CAVIAR (NCT02971020)
- Testing
- Observational/Cognitive Assessment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Minnesota Veterans Medical Research and Education Foundation
Mild Cognitive Impairment
Protocol of Multi-domain Attention Training
This study sought to investigate the changes in attention in older adults with mild cognitive impairment after Multi-domain Attention Training .
- Trial name
- NCT03379519
- Testing
- Multi-domain Attention Training (MAT), Passive information activities (PIA)
- Volunteers
- 60 people
- Sponsor
- Ministry of Science and Technology, Taiwan
Schizophrenia
Roflumilast Plus Antipsychotics Proof of Mechanism Study in Schizophrenia
The purpose of this study is to determine whether cognitive impairment associated with schizophrenia is attenuated by add-on roflumilast administration to second generation antipsychotics (SGA) in participants with stable…
- Trial name
- NCT02079844
- Testing
- Roflumilast, Second generation antipsychotic
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Takeda
Postcomatose Unawareness State, Minimally Conscious State
Eye Tracking Technology in the Diagnosis of Neurological Patients
Demonstrating that diagnostics of the state of consciousness and cognitive functions of patients with consciousness disorders performed using C-Eye X (based on eye-tracking technology) allows a more objective assessment of state…
- Conditions
- Postcomatose Unawareness State, Minimally Conscious State, Vegetative State, Disorder of Consciousness
- Trial name
- NCT05536921
- Where
- 5 sites in Poland
- Volunteers
- 90 people
- Sponsor
- AssisTech Sp. z o.o.
Menopause, Perimenopause
Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition
The goal of this clinical trial is to learn whether it is feasible to conduct a larger study comparing transdermal menopausal hormone therapy (MHT) versus no hormone therapy in menopausal women with vasomotor symptoms (hot…
- Conditions
- Menopause, Perimenopause, Vasomotor Symptoms, Cardiovascular Disease Risk Factor
- Trial name
- HERBRAVEHEART (NCT07732452)
- Testing
- Transdermal estradiol, Standard of care - non hormonal
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Multiple Sclerosis, Mild Cognitive Impairment
Effects of a CT-100 DiNaMo Component on Cognitive Functioning and Mood Symptoms
CT-100 is a platform that provides an interactive, software based therapeutic component that may be used as part of a multimodal treatment in supplementary or standalone prescription or nonprescription software-based digital…
- Conditions
- Multiple Sclerosis, Mild Cognitive Impairment, Cancer
- Trial name
- NCT05438147
- Testing
- CT-100 DiNaMo, Care-as-Usual
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Click Therapeutics, Inc.
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Evaluation of Early Identification of Cognitive Side Effects of Immunotherapy
This clinical trial evaluates the use of a tool kit, Stress, Affect, Language and Speech Analysis (SALSA), for early identification of cognitive side effects of immunotherapy compared to the standard of care assessment.
- Trial name
- NCT06414278
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Attention Deficit Disorder With Hyperactivity (ADHD)
Dual Task and Attention Deficit and Hyperactivity Disorder
When motor control deficits, sensory-perceptual deficits, and deficits in attention allocation and executive functions, often seen in ADHD, are accompanied by impairments in attentional allocation and executive function, further…
- Trial name
- NCT07150078
- Testing
- test
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gaziantep Islam Science and Technology University
Posttraumatic Stress Disorder
CBITS - Treat Trauma in Child Welfare
The goal of this randomized controlled trial is to evaluate the effectiveness of the trauma-focused group intervention CBITS compared with enhanced treatment as usual (TAU+) in child welfare programs in Germany.
- Trial name
- CBITS (NCT06038357)
- Testing
- CBITS, TAU+
- Volunteers
- 90 people
- Sponsor
- University Hospital Ulm
Communication Aids for Disabled, Communication Disorders
Outcomes of ICT Assistive Technology in RehabiliTAtIoN Pathways
The study aims to improve the quality of prosthetic intervention and verify the adequacy of assistive devices, and measurement outcomes.
- Conditions
- Communication Aids for Disabled, Communication Disorders, Motor Disorders, Cognitive Disorder
- Trial name
- ATTAIN (NCT06546813)
- Testing
- scales and questionnaire administration
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Type 2 Diabetes Mellitus, Obesity
Effects of Liraglutid, Dapagliflozin and Acarbose on the Cognitive Function, Olfactory Function, and Odor-induced Brain Activation in Overweight/Obese T2DM Patients Controlled Inadequately With Metformin Monotherapy.
This is a prospective, randomized, open label, parallel, 16-week study to explore and evaluate the therapeutic effects of liraglutid, dapagliflozin and acarbose on the cognitive function, olfactory function, and odor-induced…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Cognitive Impairment
- Trial name
- NCT03961659
- Testing
- Liraglutid, Dapagliflozin, Acarbose
- Where
- China
- Volunteers
- 87 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
General Anesthesia, Elective Laparoscopic Cholecystectomy
The Effect of Positive End-Expiratory Pressure Levels on Perfusion Index and Neurocognitive Functions in Geriatric Patients
With the increasing geriatric population, age-related physiological changes and common comorbidities increase the risk of surgical and anesthesia-related complications in this patient group.
- Trial name
- NCT07505550
- Testing
- PEEP levels
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Ankara City Hospital Bilkent
Eating Disorders
Personalized Treatment for Eating Disorders Versus CBT-E Trial
The scientific premise, developed from past work, is that treatment personalized based on idiographic models (termed Network Informed Personalized Treatment; NA-PT) will outperform the current gold-standard treatment (Enhanced…
- Trial name
- PT (NCT05195840)
- Testing
- Personalized Treatment for Eating Disorders, Cognitive Behavioral Therapy for Eating Disorders
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Louisville
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