Clinical trials: Cognitive Investigation
Attention Deficit Disorder With or Without Hyperactivity (ADHD), Children
Evaluation of the LUSHA Digital Application for Children With ADHD - Feasibility Study
Attention Deficit Disorder with or without Hyperactivity (ADHD) is a neurodevelopmental disorder characterized by a triad of symptoms combining inattention, hyperactivity, and/or impulsivity.
- Trial name
- LUSHA (NCT07204873)
- Testing
- LUSHA digital app
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Grenoble
Intracranial Tumor
Treatment Effects Inclusive Cognitive Impact and Possibilities to Individually Adjusted Treatment in Patients With Intracranial Tumors With Clinical, Neuropsychological and Imaging Parameters
The main purposes with this trial is to investigate the potential of MRI with diffusion and blood volume, flow in brain to diagnose and to measure treatment effects in patients with intracranial tumors, especially gliomas and…
- Trial name
- NCT01674582
- Testing
- MRI, neuropsychological evaluation, blood sampling
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Lund University Hospital
Frailty, Sarcopenia
Comprehensive Geriatric Assessment in Adults Aged 40 Years and Older Living With HIV
People living with HIV are experiencing longer life expectancy due to effective antiretroviral therapy; however, they may develop age-related conditions earlier than the general population.
- Trial name
- HIV-AGE40 (NCT07453303)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Premenstrual Syndrome (PMS)
Treatment of Premenstrual Syndrome - Internet-based Self-help
The purpose of this study is to determine whether an internet-based CBT (iCBT) is effective in reducing the impairment caused by premenstrual symptoms.
- Trial name
- praemensis (NCT01961479)
- Testing
- Internet-based CBT for patients with PMS, Waiting list
- Where
- Germany
- Volunteers
- 174 people
- Sponsor
- Philipps University Marburg
Cardiopulmonary Arrest, Cardiac Arrest
Evaluation of the InterFACE-AR System for Cardiopulmonary Arrest
Cognitive aids are decision support tools that present prompts to encourage recall of information, thus freeing up mental resources to increase the likelihood of desired behaviors.
- Trial name
- InterFACE-AR (NCT06411327)
- Testing
- Augmented reality, LCD Screen
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- KidSIM Simulation Program
COVID-19, Long Haul
Digital Cognition Study During Long-COVID
The persistence of the COVID-19 disease symptoms, such as extreme fatigue, shortness of breath, cardiovascular complications, depression and anxiety, pain, brain fog, loss of taste/smell, headaches as well as loss of memory has…
- Trial name
- DIGICOG (NCT06391970)
- Testing
- Cognitive screening
- Where
- Luxembourg
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Traumatic Brain Injury
Plasticity of Deep Brain Structures in Mild Cognitive Impairment and Healthy Aging
Acute and chronic cognitive impairment (TBI and MCI) is one of the most common problems in the growing and aging society of the 21st century. At an individual level, not all brain structures are affected with the same rate.
- Trial name
- PlasMA (NCT06822283)
- Testing
- transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 19 people
- Sponsor
- Friedhelm Hummel
Cognitive Decline
Preoperative Cognitive Reserve in Older Surgical Patients: A Feasibility Study
Investigators will evaluate feasibility of using a custom 6-game Lumosity brain exercise experience in busy clinical areas to obtain a quick, quantitative measure of cognitive reserve (first gameplay performance [FGP]) in older…
- Trial name
- NCT06245005
- Testing
- Brain exercise gameplay on a portable electronic device
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University
Obesity, Bariatric Surgery Candidate
Examination of Cognitive Function in Obesity and Following Weight Loss
Bariatric surgery is the most effective, long-term treatment for morbid obesity, and consistent with previous findings, individuals who lose significant weight after surgery also have improved cognition or "brain function".
- Conditions
- Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT02994186
- Testing
- Bariatric Surgery, Medical Weight Loss Program
- Sponsor
- Vanderbilt University Medical Center
Cognitive Disorders
Safety, Tolerability and Pharmacokinetics of GSK1034702 in Healthy Subjects
This is a First Time in Human Study to assess the safety, tolerability and pharmacokinetics of single doses of GSK1034702 in healthy subjects.
- Trial name
- NCT00743405
- Testing
- GSK1034702
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Atrial Fibrillation, Cognitive Symptom
Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)
Objectives: First, to determine if patients with a history of AF have acute measurable changes in cognitive functioning while in an episode of AF.
- Conditions
- Atrial Fibrillation, Cognitive Symptom, Executive Dysfunction, Cognitive Change
- Trial name
- AFCOG (NCT04033510)
- Testing
- Standard of Care Interventions to convert patient from atrial fibrillation to normal rhythm
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- David Brunk, PA-C, MMS
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Diabetes Mellitus, Hypertension
Community-based E-Health Program for Older Adults Living With Chronic Diseases
With increased aging population, there is a higher rate of having chronic diseases and cognitive impairment. In order to achieve successful aging, it is important for community-dwelling older adults to perform better…
- Conditions
- Diabetes Mellitus, Hypertension, Hyperlipidemias
- Trial name
- CeHP (NCT04560296)
- Testing
- Community-based E-Health Program, usual self-management and follow up with doctors/nurse
- Where
- 9 sites in Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cognitive Symptom, Schizophrenia
Touchscreen-based Cognitive Tests in Healthy Volunteers
This phase Ib study aims to evaluate applicability of touchscreen-based cognitive test battery for assessment of ketamine-induced schizophrenia-like cognitive deficits in healthy volunteers.
- Trial name
- NCT03469089
- Testing
- Ketamine 0.58, Ketamine 0.31, Modafinil
- Where
- Finland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Bipolar Disorder
MAPP: Imagery-focused Therapy for Bipolar Disorder
Bipolar Disorder (BD) (previously known as "manic depression") is a severe mental health illness affecting at least 1% of the population and with annual NHS cost estimated at £342 million.
- Trial name
- MAPP (NCT01981018)
- Testing
- Imagery-focused Cognitive Therapy (ImCT - psychotherapy based on CBT principles)
- Where
- 4 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
BDNF, Cognitive Functions
BDNF Levels in Cancer Patients Receiving Chemotherapy
Cognitive impairment following chemotherapy is defined as chemotherapy-induced cognitive impairment (CCIID). CCIID, which significantly reduces the quality of life of cancer patients receiving chemotherapy, develops as a result…
- Conditions
- BDNF, Cognitive Functions, Chemotherapy
- Trial name
- CARE (NCT07019324)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Cemre Aydeğer
Alzheimer Disease
Comparative Efficacy, Safety, and Tolerability of Rivastigmine 10 and 15 cm^2 Patch in Patients With Alzheimer's Disease (AD) Showing Cognitive Decline
The purpose of this study was to support the optimal use of rivastigmine patch in long-term treatment of Alzheimer's Disease in patients demonstrating functional and cognitive decline at the target maintenance dose of…
- Trial name
- NCT00506415
- Testing
- Rivastigmine 5 cm^2, Rivastigmine 10 cm^2, Rivastigmine 15 cm^2
- Where
- 145 sites in United States, Canada and 5 more
- Volunteers
- 1,584 people
- Sponsor
- Novartis Pharmaceuticals
Subjective Cognitive Decline (SCD)
PENSA+: Extended Follow-up of a Multimodal Lifestyle Intervention to Prevent Cognitive Decline in APOE-ε4 Carriers
PENSA+ is a 5-year follow-up study of participants who previously completed the PENSA clinical trial (NCT03978052), which evaluated an intensive multimodal lifestyle intervention, with or without epigallocatechin gallate (EGCG)…
- Trial name
- PENSA+ (NCT07730671)
- Where
- Spain
- Volunteers
- 121 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Mild Cognitive Impairment
Clinical Trial Through Combined tACS Therapy in Patients With Mild Cognitive Impairment
The aging of the population has led to an increase in the prevalence of disabling and high-cost diseases, such as dementia and Mild Cognitive Impairment (MCI).
- Trial name
- NCT05291208
- Testing
- Combined tACS and Cognitive Training Program, Traditional Cognitive Training Program
- Where
- Chile
- Volunteers
- 62 people
- Sponsor
- Universidad del Desarrollo
Health Status Unknown
Questionnaires and Cognitive Assessments Following Mammography
This pilot research trial studies how well questionnaires and cognitive assessments work in tracking patient symptoms following mammography.
- Trial name
- NCT03412370
- Testing
- Cognitive Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Southern California
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