Clinical trials: Cognitive Investigation
Persistent Physical Symptoms
PRINCE Primary: Integrated GP Care for Persistent Physical Symptoms - a Feasibility & Cluster Randomised Controlled Trial
PRINCE primary is cluster randomised waiting list controlled trial to evaluate the feasibility of an integrated approach to care in general practice for adults with persistent physical symptoms (PPS).
- Trial name
- PRINCE Primary (NCT02444520)
- Testing
- Integrated GP Care
- Where
- United Kingdom
- Volunteers
- 161 people
- Sponsor
- King's College London
Health Services for the Aged, Frailty
e-GAB: Electronic Geriatric Assessment Bundle: Development of an Arabic Self-administered Android CGA Application
The aim of this study is to design and assess the accuracy of administering the electronic Geriatric Assessment Bundle (e-GAB) compared to geriatrician performed comprehensive geriatric assessment (CGA) in a group of Egyptian…
- Conditions
- Health Services for the Aged, Frailty, Cognitive Impairment, Depression
- Trial name
- NCT04211285
- Testing
- e-GAB, standard physician performed CGA
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
Neurodegenerative Diseases, Aging
Simulation-informed Modelling and Personalized Evaluation (SIMPLE) in Ageing Populations
Multimodal magnetic resonance imaging (MRI), detecting brain structural and functional changes, has emerged as a powerful and promising technique to study individual's brain, as T1-weighted scans can detect morphometric features…
- Conditions
- Neurodegenerative Diseases, Aging, Brain, Cognitive Dysfunction
- Trial name
- NCT06572332
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Psychological Disability, Cognitive Impairment
Psychological Evaluation After SCS Implantation
Spinal cord stimulation (SCS) is a therapeutic option for patients with chronic low back pain (CLBP) syndrome, when pharmacological, psychological, physical and occupational therapies or surgery fail to reduce symptoms.
- Conditions
- Psychological Disability, Cognitive Impairment, Quality of Life
- Trial name
- NCT05624814
- Testing
- Spinal Cord Stimulation, Standard therapies
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University Magna Graecia
Meningioma
Evaluation of Brain Functional Changes With 18F-FDG PET and Cognitive Processes After Brain Radiotherapy for Cavernous Sinus Meningiomas and Non-secreting ACTH Adenomas
The use of radiotherapy for irradiation of all or part of the brain, in the treatment of extracerebral intracranial neoplasms, is growing rapidly, both due to the increase in diagnoses of primary tumors thanks to new imaging…
- Trial name
- NCT06180226
- Testing
- PET CT with 18 FDG .
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Cognitive-Behavioral Stress Management Device for the Treatment of Anxiety and Depressive Symptoms in Patients With Stage I-III Breast or Lung Cancer
This phase II trial studies the effect of a digital application (app), BNT001, on cognitive-behavioral stress management in patients with stage I-III breast or lung cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- BNT001 (NCT04705025)
- Testing
- Cognitive Behavior Therapy, Interview, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Alzheimer's Disease
A Study of SHR-1707 With Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease
This study aims to evaluate the safety, tolerability and pharmacodynamics of intravenous administration of SHR-1707 In patients with mild cognitive impairment due to Alzheimer's Disease or mild Alzheimer's Disease.
- Trial name
- NCT05681819
- Testing
- SHR-1707
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Posttraumatic Stress Disorder
Assessment and Treatment of Cognitive Functioning Deficits in Veterans With PTSD
Approximately half a million Veterans receiving services at the VA have Posttraumatic Stress Disorder (PTSD). PTSD is strongly associated with cognitive functioning deficits in areas of concentration, attention, memory, learning…
- Trial name
- CCTPTSD (NCT03696225)
- Testing
- Compensatory Cognitive Training (CCT), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease
Does Chronic Obstructive Lung Disease Influence the Cognitive Function
Studies have documented impaired cognitive function in patients with COPD. The possible reasons for this and correlation to the severity of the disease are not well described.
- Trial name
- NCT04458038
- Testing
- driving simulator
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Sygehus Lillebaelt
Bladder Tumor, Postoperative Cognitive Dysfunction
The Assessment of POCD After TURBT Under Spinal Anesthesia
This study evaluates the influence of premedication on cognitive functions in patients undergoing transurethral resection of bladder tumor under spinal anesthesia.
- Trial name
- NCT03029676
- Testing
- benzodiazepines, opioid, spinal anesthesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Post-Acute COVID-19 Syndrome, Cognitive Impairment
Safety, Efficacy, and Dosing of VIX001 in Patients With Neurological Symptoms of Post Acute COVID-19 Syndrome (PACS).
The study, identified as VIX001-PACS-01, is a Phase 1, open-label, dose-escalation trial evaluating the safety, tolerability, preliminary efficacy, and dose effect of VIX001, an amniotic fluid product, in patients with Post-Acute…
- Conditions
- Post-Acute COVID-19 Syndrome, Cognitive Impairment, Neurological Complication
- Trial name
- NCT05947617
- Testing
- VIX001
- Volunteers
- 9 people
- Sponsor
- Neobiosis, LLC
Malignant Neoplasm, Unspecified Adult Solid Tumor, Protocol Specific
Cognitive Assessments in Patients With Cancer Undergoing Chemotherapy
This pilot clinical trial studies cognitive assessments in patients with cancer undergoing chemotherapy. Questionnaires that measure cognitive changes during chemotherapy may help identify the side effects of chemotherapy.
- Trial name
- NCT01506440
- Testing
- cognitive assessment, quality-of-life assessment
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Wake Forest University Health Sciences
Brain Metastases, Brain Metastasis
Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases
Background: Cognitive symptoms are common and often severe in patients with brain metastases, significantly impacting their quality of life and ability to manage cancer care.
- Trial name
- NCT07355348
- Testing
- Cognitive Stepped Care Program (CSCP)
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University Health Network, Toronto
Irritable Bowel Syndrome
An Assessment of Cognitive Function in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common disorder affecting up to 20% of the general population. Despite the prevalence of the disorder, it remains poorly understood.
- Trial name
- NCT01304355
- Where
- 2 sites in Ireland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University College Cork
Stroke
Predicting Cognitive Development in Younger Stroke Patients Using the Oxford Cognitive Screen
The purpose of this study is to investigate whether Oxford Cognitive Screen (OCS) can be used as a predictive tool during hospital admission in younger (<65 years) stroke patients, i.e.
- Trial name
- STROKY (NCT05612815)
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Bispebjerg Hospital
Frail Elderly Syndrome, Cognitive Impairment
Investigating My Active and Healthy Aging
This is a multicenter, multicultural, randomized control trial. Participants will be recruited from 10 centers located in Italy, Germany, Austria, Spain, United Kingdom, Belgium, Sweden, Japan, South Korea and Australia.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Physical Dependence
- Trial name
- my-AHA (NCT03342976)
- Testing
- My-AHA platform
- Where
- Italy
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Dementia, Mild Cognitive Impairment
SAMi Intervention Study to Evaluate Smartwatch Interventions in Persons With MCI and Dementia
Assistive Technologies (ATs) can help people living with dementia (PwD) maintain their everyday activity. Still, there is a gap between potential and supply. Involving future users can close the gap.
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease, Dementia With Lewy Bodies
- Trial name
- SAIN_UMR (NCT05885620)
- Testing
- drinking reminder and cognitive task (smartwatch-based application)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Rostock
Cognitive Impairment - e.g. Dementia
Pilot Study of Cognitive Assessment in Welsh Speakers
19% of Wales' population speaks Welsh. Under the Welsh Language Act 1993, every public body providing services to the public in Wales has to prepare a scheme setting out how it will provide those services in Welsh.
- Trial name
- NCT02199782
- Testing
- Welsh language Cognitive Assessment
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Conor Martin
Rehabilitation
Factors Influencing Cardiac Rehabilitation Success
Cardiovascular diseases, especially after life-saving surgeries, require comprehensive cardiac rehabilitation (CR). We know that the effectiveness of CR varies among patients.
- Trial name
- NCT07328789
- Testing
- Rehabilitation effective
- Volunteers
- 150 people
- Sponsor
- Pomeranian Medical University Szczecin
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