Clinical trials: Cognitive Investigation
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone
The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal…
- Trial name
- NCT07392840
- Volunteers
- 50 people
- Sponsor
- Minia University
Neurodevelopmental Cognitive, Motor and Speech-language Disabilities
Assessment and Telerehabilitation of Cognitive and Motor Skills in Children With Neurodevelopmental Disabilities (Tablet Project)
The development and application of new technologies to support functional assessment and rehabilitation pathways for neurodevelopmental disabilities allow the evaluation and enhancement of cognitive, motor, and speech abilities…
- Trial name
- NCT06290297
- Testing
- Telerehabilitation VRRS
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- IRCCS Fondazione Stella Maris
Healthy
Development and Evaluation of a Cognitive Enhancement Product Made From Selected Thai Herbs for Menopausal Women
This study is set up to determine the cognitive enhancing effect and consumption safety of the novel cognitive enhancement product made from the combined extract of Z. mays (purple color) and P.
- Trial name
- NCT02567760
- Testing
- MP1
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Medulloblastoma, Childhood, Healthy Volunteers
Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized…
- Conditions
- Medulloblastoma, Childhood, Healthy Volunteers, Fossa Posterior Tumor, Low-grade Glioma
- Trial name
- CervIRM (NCT04174820)
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- 5 sites in France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Huntington Disease
Cognitive Assessment Tools for Huntington's Disease.
The purpose of the current proposal is to expand understanding of two currently available cognitive tools that are not typically used in Huntington Disease (HD) clinical trials that might be useful both for initial screening and…
- Trial name
- CAT-HD (NCT06546488)
- Testing
- Assessments
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Ohio State University
Parkinson Disease, Huntington Disease
Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders
Mild cognitive impairment associated with movement disorders occurs in up to one third of patients in early stages of the disease, and confers an increased risk of developing dementia.
- Trial name
- CogMusT (NCT05769972)
- Testing
- Immersive Virtual Reality (Parkinson's disease), Computer-based cognitive rehabilitation (Parkinson's disease), Computer-based cognitive rehabilitation (Huntington's disease)
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System, MS (Multiple Sclerosis)
Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases
This study aims to explore the imaging and electrophysiological characteristics of idiopathic inflammatory demyelinating diseases (IIDDs), and their correlation with clinical manifestations.
- Conditions
- Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System, MS (Multiple Sclerosis), NMOSD, Acute Disseminated Encephalomyelitis
- Trial name
- TACS-CI-IIDDs (NCT07087873)
- Testing
- Neuroelectrical modulation group, Pseudo-neuromodulation group
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Xuanwu Hospital, Beijing
Heart Failure, Rural Health
Forge AHEAD: Feasibility of Yoga to Improve Cognitive Function
The investigators will conduct a two-phase pilot study to test the feasibility and acceptability of a 12-week Chair Yoga intervention for 20 heart-failure patients.
- Conditions
- Heart Failure, Rural Health, Engagement, Patient
- Trial name
- Forge AHEAD (NCT07489105)
- Testing
- Yoga group
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Auburn University
Healthy
A Study to Assess the Cognitive Effects of Fesoterodine in Elderly Subjects
The study is designed to evaluate elements of cognitive function in subjects receiving either fesoterodine or alprazolam.
- Trial name
- NCT01161472
- Testing
- 4mg fesoterodine, 8mg fesoterodine, alprazolam 1mg
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hearing Loss, Age-Related
Evaluation of a Digital Therapy of Auditory Training
The aim of the study is to evaluate the efficiency of the medical device AUDISSEE in improving the perception in noise ability of presbycusis patients with hearing-aids.
- Trial name
- AUDISSEE (NCT05848661)
- Testing
- AUDISSEE
- Volunteers
- 240 people
- Sponsor
- Humans Matter
Parkinson Disease, Cognitive Dysfunction
A Study to Evaluate the Effects of SAGE-718 in Participants With Parkinson's Disease Cognitive Impairment
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance in participants with Parkinson's disease mild cognitive impairment (PD-MCI).
- Trial name
- NCT05318937
- Testing
- SAGE-718
- Where
- 38 sites in United States
- Volunteers
- 86 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Subjective Cognitive Concerns, Mild Cognitive Impairment
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched…
- Conditions
- Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
- Trial name
- NCT05881239
- Testing
- AROMHA Brain Health Test
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder, Alcohol Drinking
Virtual Incentive Treatment for Alcohol
The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention.
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
- Trial name
- VITA (NCT06265506)
- Testing
- Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington State University
Parkinson Disease
Evaluation of Anticholinergic Load
Drugs with anticholinergic properties may cause central and peripheral side effects. Several scales have been developed to evaluate the anticholinergic effect of drugs.
- Trial name
- NCT04051125
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Mild Cognitive Impairment, Dementia
Evaluation Study for the Chef Anchor 3.0 Program
Objectives: 1. (Primary)To estimate the potential effects of the cooking program on the people with MCI/dementia and their informal caregivers; 2.
- Trial name
- NCT06572748
- Testing
- 10-week programme
- Where
- Hong Kong
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Idiopathic REM Sleep Behavior Disorder, Parkinson Disease
Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk Individual
This study aims to characterize neurodegeneration progression in patients with polysomnography (PSG)-confirmed longstanding idiopathic REM sleep behavior disorder (iRBD) and to develop a prognostic model for clinical evolution…
- Conditions
- Idiopathic REM Sleep Behavior Disorder, Parkinson Disease, Neurodegeneration, Prodromal Parkinson Disease
- Trial name
- iRBD (NCT07729748)
- Testing
- Multiparametric clinical, neuropsychological, PSG and MRI assessment
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
End Stage Kidney Disease
Sarcopenia and Physical Performance in Hemodialysis Patients
Many systems such as the cardiovascular, pulmonary, musculoskeletal, hematological, immunological, gastrointestinal, central nervous system are affected due to decreased kidney function.
- Trial name
- NCT04669184
- Volunteers
- 26 people
- Sponsor
- Hacettepe University
Menopause, Perimenopause
Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition
The goal of this clinical trial is to learn whether it is feasible to conduct a larger study comparing transdermal menopausal hormone therapy (MHT) versus no hormone therapy in menopausal women with vasomotor symptoms (hot…
- Conditions
- Menopause, Perimenopause, Vasomotor Symptoms, Cardiovascular Disease Risk Factor
- Trial name
- HERBRAVEHEART (NCT07732452)
- Testing
- Transdermal estradiol, Standard of care - non hormonal
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Insomnia Chronic, Insomnia
Assessment of Usability and Preliminary Effectiveness of a Digital Sleep Aid in an Italian Sample
Chronic insomnia affects approximately 30% of the Italian population, leading to significant impairments in daily functioning and overall health.
- Trial name
- REST (NCT06926348)
- Testing
- Digital Health Technology for Chronic Insomnia, Treatment as Usual (TAU)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Universita di Verona
Age-related Functional Decline, Mild Cognitive Impairment
Health Benefits of Nutraceutical Supplementation in Older Adults.
This study examines a multi-ingredient nutraceutical designed to support several areas of health in older adults, including muscle strength, cognitive function, immune response, and inflammation.
- Trial name
- NCT07534878
- Testing
- Powder containing whey isolate and herbal extracts (30g sachet)
- Where
- India
- Volunteers
- 23 people
- Sponsor
- GPLIFE HEALTHCARE PRIVATE LIMITED
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