Clinical trials: Cognitive Investigation
Multiple Sclerosis, Relapsing Multiple Sclerosis
Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients
To assess safety and tolerability of patients converting from approved Relapsing Multiple Sclerosis (RMS) Disease Modifying Therapies (DMTs) to siponimod.
- Conditions
- Multiple Sclerosis, Relapsing Multiple Sclerosis, Advancing Multiple Sclerosis
- Trial name
- EXCHANGE (NCT03623243)
- Testing
- Siponimod
- Where
- 55 sites in United States, Puerto Rico
- Volunteers
- 185 people
- Sponsor
- Novartis Pharmaceuticals
Stroke, Ischemic Stroke
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Cognitive problems are common after a stroke and must be identified early so that rehabilitation can be initiated to improve outcome.
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral, Cognitive Dysfunction
- Trial name
- OCS-PRECISE (NCT07897916)
- Where
- 2 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen
Multiple Sclerosis, Cognitive Impairment
MODAFIMS: A Trial to Evaluate Predictors of Response to MODAFinil in Patients With Multiple Sclerosis
This is a phase II/exploratory clinical trial with a single-center, open-label design to evaluate the effect of modafinil on cognitive deficits in adult patients with multiple sclerosis and identify predictors of response using…
- Trial name
- MODAFIMS (NCT06592352)
- Testing
- Modafinil Generis 100 mg
- Where
- Portugal
- Volunteers
- 64 people
- Sponsor
- Clinical Academic Center (2CA-Braga)
Schizophrenia
Efficacy of Transcranial Direct Current Stimulation in Treatment of Cognitive Deficits in Early Stages of Psychosis
Background: Cognitive deficits are a core symptom of schizophrenia even at the early stages of psychosis. To date, there has been reliable evidence that cognitive deficits are associated with outcomes in schizophrenia and early…
- Trial name
- NCT03071484
- Testing
- Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Instituto Bairral de Psiquiatria
Cognitive Frailty
Chair Exercise and Intergenerational Activities in Older Adults With Physio-Cognitive Decline Syndrome
The goal of this clinical trial is to investigate the effects of chair exercise followed by intergenerational activity in frailty syndrome and changes in serum mBDN levels among older adults with Physio-Cognitive Decline Syndrome…
- Trial name
- PCDS (NCT07335978)
- Testing
- Intervention 1
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Atma Jaya Catholic University of Indonesia
Cognitive Dysfunction, Mild Cognitive Impairment
Development and Evaluation of Virtual Reality Experiences for Cognitive Stimulation at the Sociosanitary Center El Carme
The goal of this clinical trial is to test a virtual reality (VR)-based program designed for cognitive stimulation in individuals attending the conventional cognitive rehabilitation program at the Day Hospital of CSSC (Centro…
- Trial name
- RTCSSC (NCT06155721)
- Testing
- Virtual Reality Cognitive Stimulation Program
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Badalona Serveis Assistencials
Covid19
Early Cognitive Assessment and Evolutionary Monitoring of Patients With Severe ARDS on COVID-19 Pneumonia Requiring Mechanical Ventilation
The new coronavirus pandemic responsible for the severe acute respiratory syndrome SARS-CoV2 requires, in its severe forms, the use of invasive ventilation in intensive care.
- Trial name
- CognitiVID (NCT04468035)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Multiple Sclerosis, Electric Stimulation
Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management.
- Trial name
- NCT06968039
- Testing
- Neuroelectrics StarStim 32
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Xuanwu Hospital, Beijing
Mild Cognitive Impairment
Virtual Therapeutics for MCI
Mild Cognitive Impairment (MCI) is a term used to describe the transitional stage that occurs between normal aging and the onset of dementia.
- Trial name
- VR-MCI (NCT06079411)
- Testing
- virtual reality non-embodied, virtual reality embodied, treatment as usual
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Istituto Auxologico Italiano
Cognitive Remediation, Neuropsychology
Longitudinal Neurocognitive, Psychosocial and Health-related Quality of Life Assessment in Advanced Cancer Survivors Treated With Immunotherapy and the Efficacy of Integrative Neurocognitive Remediation Therapy
Since 2010, the field of immunotherapy has grown substantially, leading to a growing population of long-term cancer survivors treated with immunotherapy.
- Conditions
- Cognitive Remediation, Neuropsychology, Quality of Life, Psycho-Oncology
- Trial name
- CognIT (NCT05667857)
- Testing
- Integrative neurocognitive remediation therapy
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Breast Cancer
Evaluation of Cognitive Management for Chemobrain in Patients Treated for Breast Cancer.
This project will investigate the efficacy of a cognitive remediation programme in patients treated for breast cancer. patients will be randomized between "no intervention" and "intervention programme".
- Trial name
- e-ONCOGITE (NCT05690828)
- Testing
- Cognitive remediation
- Where
- France
- Volunteers
- 164 people
- Sponsor
- Institut Bergonié
Accidental Falls, Aging
Evaluation of the Effects of a Cognitive-Motor Fall Prevention Program on Fall Risk Factors
The goal of this interventional study is to compare in community dwelling elderly people the effects of two physical activity programs to prevent accident falls : "SILVER XIII EQUILIBRE" program and "VIVIFRAIL" program, on…
- Conditions
- Accidental Falls, Aging, Mild Cognitive Impairment
- Trial name
- 13EVAL (NCT05625828)
- Testing
- Cognitive-motor Physical Activity, Multifactorial Physical Activity
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- EZUS-LYON 1
Dementia, Hearing Loss
Validation Of The Flemish Montreal Cognitive Assessment (MoCA) For Persons With Hearing Impairment
The Montreal Cognitive Assessment (MoCA) is a screening test for detecting cognitive impairment that assesses several cognitive domains (attention and concentration, arithmetic and orientation, memory, etc.).
- Trial name
- MoCA-HI (NCT06400173)
- Testing
- Cognitive screening, Audiological Assessment
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- University Ghent
Aging
Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]
The ability to mount an effective immune response declines with age, leaving the elderly increasingly susceptible to infectious diseases and cancer.
- Trial name
- mTOR (NCT04742777)
- Testing
- rapamycin
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Marijuana Abuse
Effect of AEF0117 on Subjective Effects of Cannabis in CUD Subjects
Cannabis use is increasing and will only further escalate with legalization of recreational and medical cannabis use in western countries , with a prevalence greater than 30 % in the US and most European countries for individuals…
- Trial name
- NCT03717272
- Testing
- AEF0117
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Aelis Farma
Heart Diseases
Pain Assessment, Incidence & Nature in Heart Failure
Heart failure, a chronic illness afflicting 5 million persons in the United States is known to cause shortness of breath and fatigue, yet at least half of persons with heart failure also report the presence of pain.
- Trial name
- PAIN-HF (NCT00444301)
- Where
- 14 sites in United States
- Volunteers
- 349 people
- Sponsor
- PC-HEART
Obesity
Evaluation of the Healthy Lifestyle Program on Cognitive Outcomes
The goal of this study is to conduct a program of pilot research aimed at evaluating the effect of an intensive lifestyle intervention on cognitive functioning in older adults with obesity and or obesity and sarcopenia.
- Trial name
- NCT03926481
- Testing
- Evaluate Healthy Lifestyle Program on cognitive outcomes
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Social Anxiety Disorder, Interpretation Bias
Brief Interpretation Bias Modification for Social Anxiety Disorder in Pakistani Young Adults: An Experimental Evaluation
This randomized, single-blind trial tests whether one session of interpretation bias modification reduces immediate social-evaluative anxiety and shifts interpretation bias in Pakistani university students aged 18 to 25 years…
- Trial name
- BIBM-SAD-PYA (NCT07406321)
- Testing
- WSAP-based interpretation bias modification, WSAP interpretation control condition
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Ather Mujitaba
Postoperative Neurocognitive Disorders
Validation of the Modified Cognitive Assessment Scale (MoCA Blind) for the Diagnosis of Postoperative Neurocognitive Disorders in Patients With Corneal Pathology in Russia.
Long-term observation has shown that patients with visual impairment often develop cognitive impairments. Due to the fact that patients who are planning to undergo corneal transplantation may have initial cognitive deficits…
- Trial name
- NCT07423416
- Testing
- Neurocognitive testing
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Neurobehavioral Manifestations
Executive Reaction Time Test in Assessment of Cognitive Dysfunction After Aortic Valve Procedures
Up to 50% of patients undergoing surgical aortic valve operation suffer from some level of post-operative cognitive dysfunction (POCD).
- Trial name
- NCT01953068
- Where
- 2 sites in Finland
- Volunteers
- 18 people
- Sponsor
- Tampere University Hospital
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