Clinical trials: Cognitive Investigation
Cognitive Impairment Associated With Schizophrenia
Evoked Responses as Pharmacodynamic Biomarkers in Healthy and Schizophrenic Participants (MK-4334-007)
The primary purpose of this randomized, double-blind, placebo-controlled cross-over study was to record and measure 40 Hz-auditory steady-state response (ASSR) in healthy controls (HC) and participants with mild-to-moderate…
- Trial name
- NCT05136690
- Testing
- Nicotine patch, MK-4334
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Adults With Subjective Memory Complaints
Effects of Tremella Fuciformis on Improvement in Cognitive-Bio-Markers of Cognitive Functions
The objective of this study is to demonstrate the cognitive enhancement effect and safety of Tremella Fuciformis, using the cognitive and clinical indicators (e.g.
- Trial name
- NCT02377024
- Testing
- TF 600mg, TF 1200mg
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Ewha Womans University
Posttraumatic Stress Disorder
Assessment and Treatment of Cognitive Functioning Deficits in Veterans With PTSD
Approximately half a million Veterans receiving services at the VA have Posttraumatic Stress Disorder (PTSD). PTSD is strongly associated with cognitive functioning deficits in areas of concentration, attention, memory, learning…
- Trial name
- CCTPTSD (NCT03696225)
- Testing
- Compensatory Cognitive Training (CCT), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Agitation Associated With, Alzheimer's Disease
A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation
To compare the efficacy of 2 fixed doses of brexpiprazole with placebo in participants with agitation associated with dementia of the Alzheimer's type.
- Conditions
- Agitation Associated With, Alzheimer's Disease, Alzheimer's Type, Mental Disorder
- Trial name
- NCT01862640
- Testing
- Brexpiprazole, OPC-34712
- Where
- 85 sites in United States, Croatia and 5 more
- Volunteers
- 433 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Schizophrenia, Impaired Cognition
A 26-Week Extension Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy
This study is being conducted to further investigate the safety of prolonged exposure to EVP-6124 in subjects with Schizophrenia receiving a stable dose of an atypical antipsychotic who completed double-blind treatment on studies…
- Trial name
- NCT01714713
- Testing
- EVP-6124
- Where
- 128 sites in United States, Argentina and 14 more
- Volunteers
- 830 people
- Sponsor
- FORUM Pharmaceuticals Inc
Post Traumatic Stress, Overall Functioning
Randomized Controlled Trial of Supervision Strategies to Improve Clinician Fidelity to Trauma-focused CBT
The primary goal of this study is to examine the impact of varying supervision strategies on clinician fidelity and client outcomes in a community-based setting.
- Conditions
- Post Traumatic Stress, Overall Functioning, Clinician Fidelity, Supervision
- Trial name
- STEPS (NCT01800266)
- Testing
- Supervision Practices of TF-CBT
- Where
- United States
- Volunteers
- 1,280 people
- Sponsor
- University of Washington
Cognitive Dysfunction
Shanghai Non-pharmacological Intervention of Mild Cognitive Impairment
This study evaluates the effects of "computerized cognitive training" and "cognitive training plus exercise training" on different cognitive domains in mild cognitive impairment (MCI) patients.
- Trial name
- SIMPLE (NCT03119051)
- Testing
- Online cognitive training, Cognitive training plus physical exercise
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Ruijin Hospital
Subjective Cognitive Concerns (SCC)
Nonrandomized Evaluation of a Multidimensional Behavioral Intervention
This intervention is designed to promote enhanced use of compensation strategies including calendar and task list use, and organization systems, as well as increased engagement with brain health activities including physical…
- Trial name
- BBLite (NCT03717597)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cognitive Impairment, Voice Disorders
Correlation Between Montreal Cognitive Assessment and Voice Therapy Outcomes in the Aging Treatment- Seeking Population
This study will investigate if the performance on the Montreal Cognitive Assessment (MoCA) is associated or predictive of the outcomes in voice, swallowing or upper airway therapy in the older laryngology treatment seeking…
- Conditions
- Cognitive Impairment, Voice Disorders, Voicebox Disorders, Cognitive Decline
- Trial name
- MoCA (NCT05187910)
- Testing
- Speech Therapy, Swallowing Therapy, Upper Airway Therapy
- Where
- 4 sites in United States
- Volunteers
- 57 people
- Sponsor
- University of California, San Francisco
Rheumatoid Arthritis, Cardiovascular Diseases
Cardiovascular Risk Assessment for Patients With Rheumatoid Arthritis Arthritis:
One of the greatest success stories in rheumatology - the achievement of rheumatoid arthritis (RA) remission - is tempered by the fact that individuals with RA are dramatically under evaluated and under treated to reduce the risk…
- Conditions
- Rheumatoid Arthritis, Cardiovascular Diseases, Hyperlipidemias
- Trial name
- CARE RA (NCT04488497)
- Testing
- Cardiovascular Risk Assessment for Patients with Rheumatoid Arthritis, Standard of care
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer Disease, Alzheimer's Disease (Incl Subtypes)
Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - PAST Extension
The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech can detect amyloid-specific cognitive impairment in early stage Alzheimer's disease, based on…
- Conditions
- Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease
- Trial name
- PAST-US (NCT04937959)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Cardiovascular Diseases
Novel Strategies for Reducing Heart Disease Risk Disparities
This Western Pennsylvania-based study will (1) improve cardiovascular risk stratification to identify high-risk populations, (2) identify differences in cardiovascular risk, (3) evaluate mechanisms for population differences in…
- Trial name
- HeartSCORE (NCT00143923)
- Testing
- Nutrition, Exercise, Stress Management Counseling, usual care
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Health and Wellbeing
A Single Group Study to Evaluate the Effects of a Multivitamin on a Range of Health and Wellbeing Outcomes.
This is a hybrid single-group clinical trial that will last 12 weeks. Participants will take 2 capsules daily with the first meal of the day in the morning. Participants will undertake blood tests at Baseline and Week 12.
- Trial name
- NCT06568146
- Testing
- Multivitamin Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Love Wellness
Mild Cognitive Impairment
Support Groups for Patients With Mild Cognitive Impairment and Their Partners
This study aims at developing and evaluating a support group program for patients with mild cognitive impairment (MCI) and their partners. These patients have defective memory function but are not demented.
- Trial name
- NCT00285753
- Testing
- support groups
- Where
- 2 sites in Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Normal Pressure Hydrocephalus
Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)
A computerised neuropsychological test battery to be used as a standardised tool assessing the cognitive domains affected by idiopathic normal pressure hydrocephalus INPH was developed.
- Trial name
- NCT01265251
- Testing
- Computerized neuropsychological test, Conventional neuropsychological test
- Where
- Sweden
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Umeå University
No Metastatic Breast Cancer
Personalized Preventive Support for Cognitive Impairment in Non-Metastatic Breast Cancer (EFACog)
EFACog is a single-center prospective cohort feasibility study conducted on a single group of patients to study the feasibility of a personalized support program by a nurse conducted over 9 months, using face-to-face and…
- Trial name
- EFACog (NCT05538000)
- Testing
- Face to face and telephonic interviews
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut de Cancérologie de Lorraine
Mild Cognitive Impairment, Aged
South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention
This study evaluates acceptability and efficacy of multidomain intervention program to prevent cognitive impairment and protect brain health in Korean at-risk elderly.
- Trial name
- SUPERBRAIN (NCT03980392)
- Testing
- Multidomain intervention program
- Where
- 6 sites in South Korea
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Inha University Hospital
Cognitive Decline, Cognitive Impairment, Mild
Evaluation of Pilot Community-based Multi-domain Program Older Adults at Risk of Cognitive Impairment
The multi-domain programme was adapted from a larger international multi-domain interventional study for the Singapore community of older adults at risk of cognitive impairment.
- Trial name
- NCT04440969
- Testing
- Multi-domain intervention
- Where
- Singapore
- Volunteers
- 199 people
- Sponsor
- Geriatric Education and Research Institute
Alzheimer Disease
Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, 6-period crossover study to evaluate the effects of BPN14770 10 mg and 50 mg in reversing scopolamine-induced cognitive impairment in healthy volunteers.
- Trial name
- NCT03030105
- Testing
- BPN14770, Donepezil, Scopolamine 0.6 MG/ML
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Tetra Discovery Partners
Exoskeleton Device, Locomotion
Investigation of the Effects of Robot Assisted Gait Training With Virtual Reality on Cognitive Functions in Stroke Patients
It was planned to examine the effects of robot-assisted walking training supported by virtual reality on cognitive functions, quality of life and activities of daily living in individuals with subacute stroke.
- Conditions
- Exoskeleton Device, Locomotion, Stroke
- Trial name
- NCT05614141
- Testing
- Lokomat Augmented Performance Feedback, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ankara Yildirim Beyazıt University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.