Clinical trials: Cognitive Risk Assessment
Alzheimer Disease, Mild Alzheimer Disease
Repurposing Siponimod for Alzheimer's Disease
Collaboration with multiple sclerosis (MS) specialty colleagues led us to formulate the central hypothesis that Siponimod could lower the rate of brain atrophy in Alzheimer's disease (AD) subjects.
- Conditions
- Alzheimer Disease, Mild Alzheimer Disease, MCI With Increased Risk for Alzheimer Disease, Cognitive Impairment, Mild
- Trial name
- SIPO1-AD (NCT06639282)
- Testing
- Siponimod
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Idiopathic REM Sleep Behavior Disorder, Parkinson Disease
Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk Individual
This study aims to characterize neurodegeneration progression in patients with polysomnography (PSG)-confirmed longstanding idiopathic REM sleep behavior disorder (iRBD) and to develop a prognostic model for clinical evolution…
- Conditions
- Idiopathic REM Sleep Behavior Disorder, Parkinson Disease, Neurodegeneration, Prodromal Parkinson Disease
- Trial name
- iRBD (NCT07729748)
- Testing
- Multiparametric clinical, neuropsychological, PSG and MRI assessment
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Physical Inactivity
Cognitive Control to Boost Physical Activity Adherence
This trial is designed to develop and test the efficacy of cognitive training strategies to improve self-regulatory capacities for middle-aged adults to adopt and sustain a physically active lifestyle.
- Trial name
- BOOST (NCT06338774)
- Testing
- Cognitive training, Exercise
- Where
- 2 sites in United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Pathological or "at Risk" Gambling
Transversal Multiaxial Evaluation and 5-year Follow-up of a Cohort of French Gamblers (JEU)
This study is divided into two stages. The first stage is a transversal study and corresponds to the recruitment of participants, which will last about two years.
- Trial name
- NCT01207674
- Testing
- Summons of patients and filling questionnaire
- Where
- 7 sites in France
- Volunteers
- 641 people
- Sponsor
- Nantes University Hospital
Cognitive Impairment, Motoric Cognitive Risk Syndrome
Pre-FRONTal Brain STability, Key for Action Against Disability in AGing
Cognitive and mobility impairments are critical contributors to dementia and disability in older adults, and can be caused by neurodegenerative and neurovascular changes at the pre-frontal (PF) brain areas.
- Trial name
- FRONT STAGE (NCT04115215)
- Testing
- Physical exercise (PE), Transcranial current stimulation (tCS), Control
- Where
- 5 sites in Spain
- Volunteers
- 93 people
- Sponsor
- Parc Sanitari Pere Virgili
HIV Infections
Integrated Treatment of Marijuana Abuse for HIV+ Youth
This is an exploratory study that will adapt and test a combined cognitive behavioral treatment and contingency management intervention for alcohol and/or marijuana abuse for use in HIV-infected adolescents.
- Trial name
- NCT00683488
- Testing
- Focus Group, First Intervention Trial, Intervention Trial 2
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of North Carolina, Chapel Hill
Dementia, Alzheimer Disease
A Study to Evaluate the Efficacy and Safety of Galantamine in Patients With Mild Cognitive Impairment
The purpose of this study is to evaluate the efficacy and safety of galantamine treatment in patients with mild cognitive impairment.
- Trial name
- NCT00236574
- Testing
- Galantamine hydrobromide
- Volunteers
- 974 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Insomnia, Physical Health Functioning
Efficacy of a Computerized Cognitive Behavioral Treatment for Insomnia: Increasing Access to Insomnia Treatment to Decrease Suicide Risk
Insomnia is major problem among Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans.
- Conditions
- Insomnia, Physical Health Functioning, Mental Health Functioning
- Trial name
- Vets Sleep (NCT03366870)
- Testing
- Computerized Cognitive Behavioral Therapy for Insomnia, Sleep Education
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alzheimer's Disease, Aging
aeRobic Exercise and Cognitive Health
The purpose of the aeRobic Exercise and Cognitive Health (REACH) study is to understand how an aerobic exercise intervention might help promote brain health and cognition, thereby delaying the onset of clinical symptoms of…
- Trial name
- REACH (NCT02384993)
- Testing
- Enhanced Physical Activity
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cardiac Diseases, Stroke
DanceFit Prime: A Dance Based Physical Activity and Nutritional Intervention for Primary Care - A Feasibility Study
Regular physical activity improves physical and mental health and reduces the risk of heart disease, stroke, cancer, diabetes, obesity and premature death from any cause.
- Conditions
- Cardiac Diseases, Stroke, Diabetes Mellitus, Dementia
- Trial name
- DanceFit (NCT02159014)
- Testing
- Facilitated group-based aerobic dance, Online, video prompted, individual aerobic dance, Facilitated group-based nutritional intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- North Essex Partnership NHS Foundation Trust
Alzheimer's Disease
Risk Evaluation and Education for Alzheimer's Disease
The purpose of this study is to determine the characteristics of those who obtain genetic susceptibility testing for Alzheimer's disease with APOE disclosure and to study the psychological and behavioral consequences of providing…
- Trial name
- REVEAL I (NCT00571025)
- Testing
- APOE Disclosure
- Where
- 3 sites in United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Healthy, Healthy Adult Male
AI-Based Hamstring Injury Risk Analysis and Effects of the FUNBALL Program
This study investigates hamstring injury risk in football players using artificial intelligence-based motion analysis (OpenPose) and evaluates the effects of a targeted exercise intervention (FUNBALL).
- Trial name
- NCT07650006
- Testing
- FUNBALL Prevention Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Pre-Frail or Frail State
Randomized Controlled Trial of Community-based Nutritional, Physical and Cognitive Training Intervention Programmes for At Risk Frail Elderly
The aims of this proposed community-based randomized controlled trial are to evaluate the effectiveness of nutritional, physical exercise and cognitive training interventions for at-risk and frail elderly, to elucidate the…
- Trial name
- FIT (NCT00973258)
- Testing
- Nutritional Intervention, Physical Exercise, Cognitive Training
- Where
- Singapore
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- National Medical Research Council (NMRC), Singapore
Cognitive Decline, Osteoarthritis
Healthy Body & Mind Program for Older Adults Living With Osteoarthritis and Cognitive Decline
The goal of this pilot randomised clinical trial is to compare a 12-week Healthy Body \& Mind Program to usual care in older adults living with cognitive decline and osteoarthritis.
- Trial name
- NCT06070818
- Testing
- Healthy Body & Mind Program
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- The University of New South Wales
Subjective Cognitive Concerns (SCC)
Nonrandomized Evaluation of a Multidimensional Behavioral Intervention
This intervention is designed to promote enhanced use of compensation strategies including calendar and task list use, and organization systems, as well as increased engagement with brain health activities including physical…
- Trial name
- BBLite (NCT03717597)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Psychotic Disorders, Prevention
Computer-assisted Risk Evaluation in the Early Detection of Psychotic Disorders
Multicenter randomized controlled trial (RCT) with artificial intelligence (AI)-staged early diagnostics and risk-adapted treatment (RAB) as interventional treatment arm and treatment-as-usual (TAU) as control treatment arm for…
- Trial name
- CARE (NCT05813080)
- Testing
- "pronia.ai" medical device for high risk psychosis prognosis, Treatment-as-usual (TAU)
- Where
- 21 sites in Germany
- Volunteers
- 260 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Mild Cognitive Impairment (MCI)
A Prospective Cohort Study of Multimodal Biomarkers and Progression From Mild Cognitive Impairment to Dementia
This prospective, longitudinal observational cohort study will examine clinical, cognitive, blood-based, and neuroimaging features across the cognitive continuum.
- Trial name
- NCT07876570
- Testing
- Observational Multimodal Assessment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Delirium
Standardization of a Novel Self-administered Tablet Computer-based Clinical Screening Tool for Adverse Postoperative Cognitive Outcomes
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common complications after surgery and may affect elderly patients in particular.
- Trial name
- CogCheck-Norm (NCT02708823)
- Testing
- CogCheck application
- Where
- Switzerland
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Nicolai Goettel
Breast Cancer, Cardiovascular Risk
Time Restricted Eating in Survivors Trial 2.0
After chemotherapy, older breast cancer survivors experience a faster decline in brain function. This can make it harder to enjoy life, stay social, and maintain independence.
- Conditions
- Breast Cancer, Cardiovascular Risk, Cognitive Function, Physical Function
- Trial name
- TEST2 (NCT07259434)
- Testing
- Time Restricted Eating, Healthy Eating Education
- Where
- Canada
- Volunteers
- 152 people
- Sponsor
- University of Toronto