Clinical trials: Cognitive Risk Assessment
Community Adolescents at Risk for Depression and Suicide
Application and Evaluation of Group Cognitive Intervention for Depressed Adolescents
Cognitive behavioral therapy (CBT) is effective and CBT with parental involvement has potential in preventing and treating adolescent depression.
- Trial name
- NCT00946413
- Testing
- CBT plus parent education, CBT alone
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- Taipei Medical University Hospital
Geriatric Depression
Community-based Rehabilitation Management for Patients With Remitted Geriatric Depression
This study intends to take patients with RGD as objects. Further construct a community-based rehabilitation management (CBRM) program with drug treatment, rehabilitation measures of education, psychology and exercise as its core…
- Trial name
- NCT05610917
- Testing
- CBRM (community-based rehabilitation management), TAR(treatment as routine)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Duan Li
Cognition Disorders
Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study
The LEARN study a multicenter, observational study will that will evaluate the rate of cognitive change in approximately 500 clinically normal older individuals who "screen-fail" for the A4 trial on the basis of their screening…
- Trial name
- LEARN (NCT02488720)
- Where
- 40 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Frailty, Sarcopenia
Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.
- Conditions
- Frailty, Sarcopenia, Sarcopenia in Elderly, Muscle Strength
- Trial name
- NCT06988176
- Testing
- Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Mild Cognitive Impairment
Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease
Physical exercise has proven to improve memory including in the elderly. Drugs developed to stop the underlying disease processes that cause Alzheimer's disease may succeed only with multimodal efforts to stimulate brain…
- Trial name
- NCT01811381
- Testing
- Curcumin, aerobic yoga, non aerobic yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
HIV (Human Immunodeficiency Virus), Sexually Transmitted Diseases
Reality Check: An HIV Risk Reduction Serial Drama
African Americans have considerably higher rates of HIV infections than do White, Hispanic, Asian, and Native Americans. African Americans accounted for 59% of all diagnoses of HIV infection among youth (13-24 years of age) in…
- Trial name
- RC (NCT03352219)
- Testing
- Reality Check, Physical Activity Attention Control
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
The goal of this clinical trial is to learn whether a hybrid multidomain lifestyle program can prevent cognitive decline and reduce dementia risk in community-dwelling adults in mid- to late life who are at increased risk of…
- Trial name
- LETHE-AT (NCT07376135)
- Testing
- A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
- Where
- 3 sites in Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Frailty, Pre-Frailty
In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults
The goal of this clinical trial is to determine whether a 6-month healthy-aging education program delivered in person, online, or in a hybrid format reduces frailty and is cost-effective compared with usual care in…
- Trial name
- FRAGSALUD-ON (NCT07738393)
- Testing
- In-person healthy aging education program, Hybrid healthy aging education program, Online healthy aging education program
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- University of Cadiz
Sleep Deprivation
EEG Analysis for the Objective Assessment of Drowsiness
The objective of this clinical study is to develop solutions for the evaluation and management of drowsiness, based on 2 EEG sensors only, aiming at reducing the risk of accidents related to secondary hypersomnolence (sleepiness…
- Trial name
- MEEGASAFE (NCT05453643)
- Testing
- sleep deprivation patterns
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Physip S.A
Mild Cognitive Impairment, Healthy
The Aerobic & Cognitive Exercise Study
The purpose of this study is to clarify the benefits to brain health and thinking processes that result from different forms of exercise.
- Trial name
- ACES (NCT02237560)
- Testing
- Cybercycle-Game, Cybercyle-Tour, Game Only
- Where
- 12 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Union College, New York
Cognitively Normal Older Adults, Hypertension
Risk Reduction for Alzheimer's Disease
Physical inactivity, high blood pressure and dyslipidemia are risk factors for Alzheimer's disease (AD) and vascular dementia. Importantly, these risk factors are modifiable with lifestyle changes, pharmacological treatment, or…
- Conditions
- Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Alzheimer's Disease
- Trial name
- rrAD (NCT02913664)
- Testing
- Angiotensin II receptor blocker (ARB, losartan) and calcium channel blocker (CCB, amlodipine), Aerobic Exercise Training, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 513 people
- Sponsor
- University of Texas Southwestern Medical Center
Cognitive Function 1, Social, Mental Health Wellness 1
Effects of an Exercise Program on Cognition and Brain in Overweight/Obese Preadolescent Children
The ActiveBrains project aims to examine whether a 5-months physical exercise program has benefits on cognition and brain, as well as on selected physical and mental health outcomes in preadolescent overweight/obese children.
- Conditions
- Cognitive Function 1, Social, Mental Health Wellness 1, Obesity, Overweight
- Trial name
- ActiveBrains (NCT02295072)
- Testing
- A 5-months physical exercise-based program
- Volunteers
- 110 people
- Sponsor
- Universidad de Granada
Memory Disorders, Mild Cognitive Impairment
Physical Exercise for Prevention of Dementia
The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Aging
- Trial name
- EPD (NCT02236416)
- Testing
- Intervention group, Control group
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Molise
Biomarkers, Cognitive Assessment
Neuropsychological Indicators of SCD Progression
Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified.
- Conditions
- Biomarkers, Cognitive Assessment, Cognitive Decline, Neurocognitive Disorders
- Trial name
- SCD-CI (NCT04880252)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Polypharmacy (Individuals Treated With 4 or More Medications)
THE EFFECTS OF MULTIPLE DRUG USE ON BALANCE, FALL RISK, AND COGNITIVE STATUS
This study aims to evaluate the effects of polypharmacy on balance, fall risk, cognitive status, vestibular function, and hearing among individuals living in nursing homes.
- Trial name
- NCT07816276
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Aging, Functional Status
Remote Physical and Cognitive Training Effects in Older Adults at Increased Risk of Clinical-functional Vulnerability
This study is a randomized, single-blind, parallel, controlled, superiority trial. The main objective is to verify the chronic effects of a remote 12-week low-intensity physical training program alone or in combination with…
- Trial name
- NCT05309278
- Testing
- Physical training, Cognitive training
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Dementia, Aerobic Exercise
Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, Balance, Fall Risk, Reaction Time, Cognitive Functions and Quality of Life in Dementia Patients
Dementia is a clinical disorder characterized by progressive and permanent loss of multiple cognitive functions, especially memory, at a level that affects activities of daily living.
- Conditions
- Dementia, Aerobic Exercise, Balance Exercise, Cognitive Function
- Trial name
- NCT05839743
- Testing
- Aerobic Exercise, Balance Exercise, Combined Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Yuksek Ihtisas University
Cognitive Dysfunction, Postoperative, Cognitive Dysfunction
Assessment of Brain Oxygen Drops During Surgery and Related Risk Factors for Cognitive Problems After Heart Surgery
This study examines whether decreases in brain oxygen levels during cardiac surgery are linked to postoperative cognitive dysfunction and identifies other factors that may increase the risk of cognitive impairment.
- Conditions
- Cognitive Dysfunction, Postoperative, Cognitive Dysfunction, Cardiac Surgery
- Trial name
- NCT07361068
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Older Adults, Physical Function
Curcumin and Function in Older Adults
This placebo-controlled RCT tests whether dietary supplementation with curcumin maintains or improves cognitive and physical function in older adults who are at high risk of functional decline due existing (mild) functional…
- Conditions
- Older Adults, Physical Function, Cognitive Function
- Trial name
- SPICE (NCT03085680)
- Testing
- Curcumin, microcrystalline cellulose
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Cardiovascular Risk Factor
A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.
The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without…
- Trial name
- ACTIONcR (NCT04962061)
- Testing
- Cognitive Training, Aerobic and resistance exercises, Stretching and Toning
- Where
- Canada
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Louis Bherer