Clinical trials: Cognitive Symptom
Pain, Acute, Pain, Chronic
Development and Validation of a Digital Pain-Reduction Kit for Musculoskeletal Injuries
This study will test the effectiveness of an evidence-based, multi-modal, "digital pain-reduction kit" as a non-pharmacological supplement to managing patients with pain due to musculoskeletal injuries.
- Trial name
- NCT03187132
- Testing
- Digital Pain Reduction Kit, Active Control
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Cedars-Sinai Medical Center
Mania
Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania
The purpose of this study is to see if taking a substance called omega-3 fatty acids is effective, safe, and well-tolerated for treating adolescents with major depressive disorder (also called simply "depression" or "clinical…
- Trial name
- R34 (NCT00917501)
- Testing
- OMega 3
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Agitation in Patients With Dementia of the Alzheimer's Type
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
This study was conducted to evaluate the efficacy, safety, and tolerability of AVP-786 (deudextromethorphan hydrobromide [d6-DM]/quinidine sulfate [Q]) compared to placebo for the treatment of agitation in participants with…
- Trial name
- NCT04464564
- Testing
- AVP-786
- Where
- 106 sites in United States, Belgium and 11 more
- Volunteers
- 241 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Pectus Excavatum
Prospective Trial: Pain Management After Pectus Excavatum Repair, Epidural Versus PCA
Pectus excavatum, the most common chest wall deformity, occurs in roughly one in 1000 children. Operative repair of the anterior thoracic concavity has transitioned to the minimally invasive approach with substernal bar placement…
- Trial name
- PectusEpiPCA (NCT01863498)
- Testing
- Epidural, PCA
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Children's Mercy Hospital Kansas City
Alzheimer's Disease
Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease
The primary purpose of this study is to determine whether ELND005 is effective in treating symptoms of agitation and aggression in patients with Alzheimer's disease
- Trial name
- NCT01735630
- Testing
- ELND005
- Where
- 70 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- OPKO Health, Inc.
Depression
Effects of Cognitive Behavioral Therapy on Brain Serotonin Activity in People With Depression
This study will examine changes in brain serotonin activity in people with depression before and after they receive cognitive behavioral therapy.
- Trial name
- NCT00641108
- Testing
- ADAM SPECT plus Cognitive Therapy, ADAM SPECT plus No Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pain, Breast
The Use Of Liposomal Bupivacaine For Pain Control
The purpose of this research study is to determine how well the local anesthetic, liposomal bupivacaine, controls postoperative pain after mastectomy and breast reconstruction.
- Trial name
- NCT03722927
- Testing
- Bupivacaine, Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Hernia
EXPAREL Infiltrated Into the TAP for Postoperative Analgesia in Unilateral Abdominal Hernia Repair
Phase 4 study evaluating the effectiveness of EXPAREL when infiltrated into the the Transversus Abdominis Plane (TAP).
- Trial name
- 702 (NCT01801124)
- Testing
- EXPAREL
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Williams Syndrome, Anxiety
Buspirone Treatment of Anxiety in Williams Syndrome
The purpose of this study is to do a preliminary assessment of whether buspirone is effective, safe, and tolerable in the treatment of anxiety in children, adolescents, and adults with Williams syndrome.
- Trial name
- NCT04807517
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury, Fatigue
Treatment of Post-Traumatic Brain Injury (Post-TBI) Fatigue With Light Therapy
This study aims to evaluate the efficacy of 4 weeks of daily light exposure in reducing Post-Traumatic Brain Injury (TBI) Fatigue immediately post-treatment and at a one-month follow up.
- Trial name
- NCT01725750
- Testing
- Bright White Light (BWL), Dim Red Light (DRL)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Syncope
Diagnostic Yield of an Ambulatory Patch Monitor in Unexplained Emergency Department Syncope: A Pilot Study (PATCH-ED)
Syncope is a common Emergency Department (ED) presentation but the underlying diagnosis is not apparent in 60% of patients after assessment and serious adverse event rate is 7% at one month with most having acute cardiovascular…
- Trial name
- PATCH-ED (NCT02683174)
- Testing
- Novel ambulatory patch (ZIO® XT Patch), BNP and hs-troponin I at 0 and 3 hours post ED attendance
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- NHS Lothian
Chronic Pain, Mild Cognitive Impairment
Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain
We aim to conduct a pilot randomized controlled trial comparing 2 symptom management programs for older adults with self-reported memory problems and chronic pain, Active Brains 1 and Active Brains 2.
- Conditions
- Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
- Trial name
- NCT04044183
- Testing
- Active Brains 1, Active Brains 2
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Depression, Subclinical Depressive Symptoms
Cognitive Training Video Game to Target Subclinical Depressive Symptoms in Youth
The purpose of the study is to determine how cognitive control training (CCT) changes behavior in youth with subclinical depressive symptoms.
- Trial name
- NCT05697627
- Testing
- Computerized cognitive training (CCT) using EndeavorRx
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Michigan
Chronic Pain, Central Sensitisation
Mechanisms Of Change in Adolescent Pain Self-management
The MOCAS Study aims to describe the mechanisms through which sleep deficiency affects youth responses to an online pain self-management intervention over a 6-month period.
- Conditions
- Chronic Pain, Central Sensitisation, Headache
- Trial name
- MOCAS (NCT04043962)
- Testing
- Web-based CBT (Web-MAP)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Seattle Children's Hospital
Hoarding Disorder, Hoarding
Hoarding Disorder Treatment With Virtual Reality
This study explores whether a facilitated peer support group called Buried in Treasures (BIT) and a virtual reality decluttering practice can help individuals with clutter challenges.
- Conditions
- Hoarding Disorder, Hoarding, Clutter
- Trial name
- HDVR (NCT03828461)
- Testing
- Facilitated group therapy with behavioral practice; 16 weeks
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stanford University
Obstructive Sleep Apnea, Mild Cognitive Impairment
Mild Cognitive Impairment and Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) has been linked to increased risk for Alzheimer's disease (AD), but little prospective evidence exists on the effects of OSA treatment in preclinical AD.
- Trial name
- MEMORIES (NCT01482351)
- Testing
- CPAP adherence intervention, Attention control intervention
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- George Mason University
Suicide, Attempted
Inpatient Cognitive-Behavioral Therapy to Reduce Suicide Risk Post-Discharge
The goal of this randomized-controlled trial is to determine whether adding brief cognitive-behavioral therapy for suicide prevention (BCBT) to inpatient treatment improves suicide-related outcomes after the person leaves the…
- Trial name
- NCT04168645
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Hartford Hospital
Neurobehavioral Disinhibition
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury
This is a multicenter, randomized, placebo-controlled study to evaluate AVP-786 for the treatment of neurobehavioral disinhibition including aggression, agitation, and irritability in participants with traumatic brain injury…
- Trial name
- NCT03095066
- Testing
- AVP-786-28, AVP-786-42.63
- Where
- 54 sites in United States
- Volunteers
- 168 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Postoperative Pain, Bunions
Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy
A Phase 2, Randomized, Controlled, Multicenter, Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy
- Trial name
- NCT02762929
- Testing
- HTX-011A, HTX-011B, HTX-002
- Where
- 5 sites in United States
- Volunteers
- 430 people
- Sponsor
- Heron Therapeutics
Fragile X Syndrome
Study of SPG601 in Adult Men With Fragile X Syndrome
This Phase 2 study described herein will evaluate the safety, efficacy, tolerability, pharmacokinetics and pharmacodynamics of SPG601 in adult men with Fragile X syndrome.
- Trial name
- NCT06413537
- Testing
- SPG601
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Spinogenix
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