Clinical trials: Cognitive Symptom
Covid19, Intellectual Disability
Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic
The primary goal of this project is to identify the best messaging and implementation strategies to maximize SARS-CoV-2 testing for children with intellectual and developmental disabilities (IDD) and their teachers to help ensure…
- Conditions
- Covid19, Intellectual Disability, Developmental Disability, Child Development Disorder
- Trial name
- NCT04565509
- Testing
- Standard Messaging, Enhanced Messaging, COVID-19 Testing
- Where
- 3 sites in United States
- Volunteers
- 1,143 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Adolescent Behavior, Intellectual Disability
Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities
The objective of this study is to compare the effect of two strategies to increase MVPA in adolescents with intellectual and developmental disabilities (IDD): a single level intervention delivered to the adolescent only, and a…
- Conditions
- Adolescent Behavior, Intellectual Disability, Down Syndrome, Physical Activity
- Trial name
- NCT03684512
- Testing
- Group Exercise Sessions, Individual Support Sessions, Facebook Group
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of Kansas
Attention Deficit Hyperactivity Disorder, Dyslexia
Treatment of ADHD With Atomoxetine in Children & Adolescents With ADHD & Comorbid Dyslexia
This study will evaluate the effect of atomoxetine in treating Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in children and adolescents with ADHD and comorbid reading disability (dyslexia)
- Trial name
- NCT00607919
- Testing
- Atomoxetine
- Where
- 16 sites in United States
- Volunteers
- 209 people
- Sponsor
- Eli Lilly and Company
Chronic Post-Surgical Pain
Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA
A significant number of patients develop chronic post-surgical pain (CPSP) following knee replacement surgery. Proposed is the testing of a novel computer-assisted behavioral intervention integrating motivational interviewing in…
- Trial name
- NCT04814992
- Testing
- Computer-Assisted Preoperative CBT Intervention (PAINTrainer)
- Where
- 4 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brain Tumor
Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning
Primary Objective: To assess the efficacy of immediate release methylphenidate, sustained release methylphenidate, and the novel vigilance enhancing drug modafinil for the improvement of cognitive functioning in patients with…
- Trial name
- NCT00418691
- Testing
- IR Methylphenidate, Modafinil, SR Methylphenidate
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Gynecologic Cancer, Post-operative Pain
Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
This study is a single-center, randomized, placebo-controlled, double-blind clinical trial. The purpose of this study is to evaluate the impact of pre-operative transverses abdominis plane (TAP) blocks on post-operative analgesia…
- Trial name
- NCT01444924
- Testing
- Bupivicaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Wisconsin, Madison
Bipolar Disorder, Mania
Safety and Efficacy of Cariprazine for Mania
The objective of this study is to evaluate the efficacy, safety, and tolerability of cariprazine monotherapy versus placebo for the treatment of acute manic or mixed episodes associated with bipolar I disorder.
- Trial name
- NCT01058096
- Testing
- Cariprazine
- Where
- 28 sites in United States, India
- Volunteers
- 323 people
- Sponsor
- Forest Laboratories
Pain
Evaluation of DEX-IN During Outpatient Procedures
The primary objective of this study is to evaluate the analgesic efficacy of DEX-IN compared with placebo and active control (fentanyl), in subjects undergoing painful outpatient and office based procedures.
- Trial name
- NCT03348423
- Testing
- DEX-IN, Fentanyl
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baudax Bio
Major Depressive Disorder, Cognitive Behavior Therapy
Using a Text-message System to Engage Depressed Adolescents in Cognitive-behavioral Therapy Homework
The primary goal of the pilot is to test the feasibility and utility of using a text-messaging system to engage adolescents in improved homework adherence during cognitive-behavioral therapy (CBT) for major depressive disorder.
- Conditions
- Major Depressive Disorder, Cognitive Behavior Therapy, Text Messaging
- Trial name
- NCT00919932
- Testing
- Paper and pen homework, Text message system homework.
- Volunteers
- 9 people
- Sponsor
- University of Pittsburgh
Alzheimer's Disease
Trial of Carvedilol in Alzheimer's Disease
This is a 6-month pilot randomized double-blind placebo-controlled trial of carvedilol, with the primary objective being to determine whether carvedilol treatment is associated with improvement in Alzheimer's Disease (AD) as…
- Trial name
- NCT01354444
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Johns Hopkins University
Stroke, Aphasia
Evaluating Anodal tDCS Preceding Aphasia Therapy
The purpose of this study is to determine if non-invasive brain stimulation (transcranial direct current stimulation) delivered prior to language therapy will improve word-finding in individuals with aphasia who are 6 months or…
- Trial name
- NCT02249819
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwell Health
Brain Death, Organ Donors
Naloxone for Optimizing Hypoxemia Of Lung Donors
Brain-dead patients who provide authorization for organ donation will be randomized to naloxone or placebo if baseline arterial blood gas (ABG) after initiation of OPO (Organ Procurement Organization) management reveals…
- Conditions
- Brain Death, Organ Donors, Lung Transplantation
- Trial name
- NO-HOLDS (NCT02581111)
- Testing
- Naloxone, Normal saline
- Where
- 4 sites in United States
- Volunteers
- 199 people
- Sponsor
- Washington University School of Medicine
Hematopoietic Stem Cell Transplantation, Cognitive Impairments
The "Light for the Brain" Study
Cognitive impairment (such as memory problems) due to cancer and its treatment can interfere with quality of life and can linger long after treatment has ended, yet research examining cognitive rehabilitation approaches has…
- Conditions
- Hematopoietic Stem Cell Transplantation, Cognitive Impairments, Sleep, Depression
- Trial name
- NCT02677987
- Testing
- Intervention systematic light exposure, Comparison systematic light exposure
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Northwestern University
Hemorrhoid
Study of Pain Control in Hemorrhoidectomy
Patients will get an injection of either SKY0402 or placebo during hemorrhoid surgery, and their pain and pain medicine use will be monitored.
- Trial name
- NCT00890721
- Testing
- SKY0402
- Where
- Poland
- Volunteers
- 189 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Arthritis, Rheumatoid
Low Dose Naltrexone for Chronic Pain From Arthritis
Over 100 million Americans report chronic pain. Veterans are disproportionately affected for multiple reasons, including injuries and post-traumatic stress disorder.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- LDN-VA (NCT03008590)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Delirium
Delirium in the Emergency Department: Novel Screening
Delirium is an acute confusional state characterized by altered or fluctuating mental status, inattention, and either disorganized thinking or an altered level of consciousness.
- Trial name
- NCT01162343
- Where
- United States
- Volunteers
- 498 people
- Sponsor
- Vanderbilt University Medical Center
Gait Disorder
Cognitive Training and Dual-task Ability
The first goal of this study is to examine the extent to which the inclusion of dual-task practice to standard balance rehabilitation results in greater benefits to dual-task ability.
- Trial name
- NCT01895608
- Testing
- Balance rehabilitation + dual-tasking, Standard balance rehabilitation, Cognitive training (speed of processing)
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Down Syndrome
Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome
The purpose of this study is to test in adults with Down Syndrome the safety, tolerability and immunogenicity of a vaccine, ACI-24.
- Trial name
- 3-Star (NCT02738450)
- Testing
- ACI-24 low dose, ACI-24 high dose
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- AC Immune SA
Surgical Remove of Hemorrhoids
Safety and Efficacy of the Addition of Morphine Chloride to a Low Dose of Bupivacaine as Intradural Anaesthetic for the Removal Surgery of the Hemorrhoids
A single blind, randomized, with blinded evaluation by third parties clinical trial is carried out to assess the analgesic efficay of the addition of morphine chloride to a low dose solution of spinal local anaesthetic compared…
- Trial name
- NCT02046772
- Testing
- Bupivacaine low dose, Bupivacaine standard dose, Morphine Chloride
- Where
- 2 sites in Spain
- Volunteers
- 63 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias
Prader-Willi Syndrome
Growth Hormone Use in Adults With Prader-Willi Syndrome
The main research question this protocol aims to answer is whether treatment with growth hormone will impact body composition, quality of life, and energy balance in PWS adults, and if there is a loss of effects after cessation…
- Trial name
- NCT00444964
- Testing
- Nutropin AQ
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Children's Mercy Hospital Kansas City
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