Clinical trials: Cognitive Therapy
Schizophrenia
A Study to Assess the Safety and Efficacy of ASP4345 as Add-on Treatment for Cognitive Impairment in Subjects With Schizophrenia on Stable Doses of Antipsychotic Medication
The purpose of this study was to evaluate the efficacy of ASP4345 on cognitive impairment compared to placebo using change from baseline in MATRICS Consensus Cognitive Battery (MCCB) neurocognitive composite score (excluding…
- Trial name
- NCT03557931
- Testing
- ASP4345, risperidone, quetiapine
- Where
- 27 sites in United States
- Volunteers
- 233 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Generalized Anxiety Disorder
Combined Treatment for Generalized Anxiety Disorder (GAD)
The purpose of this study is to conduct a preliminary evaluation of the efficacy of combined medication and psychotherapy for generalized anxiety disorder (GAD).
- Trial name
- NCT00620776
- Testing
- Cognitive Behavioral Therapy, Venlafaxine XR
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pennsylvania
Obsessive-Compulsive Disorder in Children, Social Anxiety Disorder of Childhood
Parent-based Treatment for Youth With Anxiety and Obsessive-compulsive Disorder
Anxiety and obsessive-compulsive disorders are the most common mental health disorders in childhood and adolescence. A parenting intervention for youth with anxiety, called Supportive Parenting of Anxious Childhood Emotions…
- Conditions
- Obsessive-Compulsive Disorder in Children, Social Anxiety Disorder of Childhood, Obsessive-Compulsive Disorder in Adolescence, Separation Anxiety
- Trial name
- NCT04922502
- Testing
- Standard SPACE, Bibliotherapy, low therapist contact SPACE
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Schizophrenia
Predictors of Response to Cognitive Remediation in Schizophrenia
The purpose of this study is to determine which variables predict improvement on a cognitive training task battery, used for patients with schizophrenia, and to determine the proportion of patients whose performance returns to…
- Trial name
- NCT00333970
- Testing
- cognitive remediation
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- US Department of Veterans Affairs
Social Anxiety Disorder, Selective Mutism
Treatment of Social Anxiety Disorder and Selective Mutism
This study is to assess the efficacy of a brief, 11-week, manualized Taming Sneaky Fears for Social Anxiety Disorder (SAD) and/or Selective Mutism (SM) child and parent group Cognitive Behavioural Therapy (CBT) treatment…
- Trial name
- SAD&SMTRMT (NCT02554929)
- Testing
- Taming Sneaky Fears, Parent Psycho-education and Child Socialization
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- The Hospital for Sick Children
PTSD, Substance Use Disorders
Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
With this research, the investigators hope to learn if cognitive behavioral therapy (CBT) for posttraumatic stress disorder (PTSD) works in people who have both PTSD and problems with drugs or alcohol.
- Trial name
- CBT (NCT01357577)
- Testing
- Cognitive behavioral therapy for PTSD
- Where
- 3 sites in United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Telemental Health and Cognitive Processing Therapy for Rural Combat Veterans With Posttraumatic Stress Disorder
The immediate objective of this project was to evaluate the clinical effectiveness of a telemental health modality (video-teleconferencing) for providing an evidence-based group intervention (Cognitive Processing Therapy; CPT) to…
- Trial name
- CPTVTEL (NCT00879255)
- Testing
- Cognitive Processing Therapy Group Videoteleconference, Cognitive Processing Therapy Group In-Person
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- US Department of Veterans Affairs
Depression
Fevarin® Effectiveness in Treatment of Depression in Patients With Neurological Disorder
Prospective, multicenter, non-comparative, observational program to describe prevalence of depressive symptoms in a variety of neurological disorders and effects of Fevarin® on the severity of anxiety and depression, sleep state…
- Trial name
- FRIENDS (NCT02043197)
- Where
- 29 sites in Russia
- Volunteers
- 300 people
- Sponsor
- Abbott
Widespread Chronic Pain
The Maintaining Musculoskeletal Health Study
It is known from many studies that when patients have developed chronic widespread pain (CWP) or fibromyalgia that managing such symptoms is extremely challenging for both doctors and patients.
- Trial name
- MAmMOTH (NCT02668003)
- Testing
- Cognitive Behavioural Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,002 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Influenza
Effect of Oseltamivir on Cognitive Function in Subjects With Influenza
This study has been designed to determine if subjects treated with oseltamivir in addition to standard of care treatment for influenza demonstrate a greater improvement in attention / working memory / processing speed / mood as…
- Trial name
- FOCUS (NCT01249833)
- Testing
- Oseltamivir
- Where
- 16 sites in Canada
- Volunteers
- 122 people
- Sponsor
- Trial Management Group Inc.
Depression, End Stage Renal Disease
A Trial of Sertraline vs. CBT for End-stage Renal Disease Patients With Depression {ASCEND}
Patients whose kidneys fail generally require dialysis treatments to sustain life. The ability of patients to make major adjustments in their lives for dialysis is hampered by depression that affects almost one-quarter of such…
- Trial name
- ASCEND (NCT02358343)
- Testing
- Engagement Interview, Cognitive Behavioral Therapy, Antidepressant Drug Therapy
- Where
- 3 sites in United States
- Volunteers
- 184 people
- Sponsor
- University of Washington
Cannabis Use Disorder, Cannabis Withdrawal
Progesterone for Cannabis Withdrawal
Sex and gender differences in behavioral, biological, and clinical correlates of substance use disorders are myriad, yet there exists a dearth of gender-informed treatment options.
- Trial name
- NCT03430050
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder, Tobacco Dependence
Tobacco Treatment as Augmentation for Cognitive Processing Therapy for PTSD
The purpose of this study is to examine whether tobacco affects recovery from PTSD. There are 3 goals of the study; (1) to test if quitting tobacco prior to PTSD treatment affects treatment success, (2) to test how PTSD symptoms…
- Trial name
- NCT02012452
- Testing
- Tobacco treatment, Health Education
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder
Increasing Engagement in Evidence-Based PTSD Therapy for Primary Care Veterans
The purpose of this study is to implement an evidence-based Referral Management System that will address patient and system-level barriers to the uptake of evidence-based psychotherapy for PTSD by Veterans Affairs primary care…
- Trial name
- NCT01984515
- Testing
- Referral Management System
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Malignant Glioma
Nuvigil or Placebo in Newly Diagnosed Malignant Glioma
The purpose of this study is to determine if Nuvigil® improves fatigue experienced by people receiving external beam radiation therapy for the treatment of malignant gliomas.
- Trial name
- NCT01400958
- Testing
- Nuvigil®
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Alzheimer's Disease
An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease
The purpose of this study is to evaluate the efficacy and safety of two fixed doses (16mg/day and 24mg/day) of galantamine (a drug for treating dementia) versus placebo for the treatment of patients with Alzheimer's disease.
- Trial name
- NCT00814801
- Testing
- Galantamine 16 mg/day, Galantamine 24 mg/day
- Where
- Japan
- Volunteers
- 580 people
- Sponsor
- Janssen Pharmaceutical K.K.
Autism Spectrum Disorder
Oxytocin and Social Cognitive Skills Groups
The purpose of this study is to evaluate the feasibility, safety, and preliminary efficacy of integrating targeted dosing of intranasal oxytocin with a social cognitive skills group therapy for school-aged children with autism…
- Trial name
- ION-ASD (NCT02918864)
- Testing
- Oxytocin, Social Cognitive Skills Training, Facilitated Play Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center
Cocaine Dependence
Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Modafinil, a medication that enhances mood, increases energy, and improves concentration, may be useful in preventing…
- Trial name
- NCT00218387
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Medical University of South Carolina
Insomnia, Depression
Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)
There is a strong association between sleep disturbance and suicidal thoughts and behaviors. Sleep disturbance is also highly comorbid with other common conditions associated with suicide such as depression and posttraumatic…
- Conditions
- Insomnia, Depression, Posttraumatic Stress Disorder, Suicidal Ideation
- Trial name
- NCT02248675
- Testing
- CBT-I, TAU
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
Physical Activity for Older Adults Chronic Low Back Pain
Chronic low back pain (cLBP) is one of the most common and disabling conditions among US military Veterans. Although physical activity can improve cLBP outcomes, the majority of Veterans with cLBP are inactive.
- Trial name
- PACe-LBP (NCT02327325)
- Testing
- Physical Activity, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development