Clinical trials: Cohort
Head and Neck Squamous Cell Carcinoma
Two-cohort Study of Niraparib and Dostarlimab Plus (Chemo)RadIotherapy in Locally-Advanced Head and Neck Squamous Cell Carcinoma
Multi-center, open-label, non-randomized, non-comparative two-cohort study for patients with locally-advanced squamous cell carcinoma arising from the larynx, hypopharynx, oropharynx (Stage III, IVA and IVB according to 8th…
- Trial name
- RADIAN (NCT05784012)
- Testing
- Dostarlimab, Niraparib, cisplatin plus radiotherapy
- Where
- 7 sites in Spain
- Volunteers
- 34 people
- Sponsor
- Grupo Español de Tratamiento de Tumores de Cabeza y Cuello
Alpha 1-Antitrypsin Deficiency, Genetic Disease
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease
Alpha-1 Anti-trypsin Deficiency (AATD) is a genetic disease with lung and liver disease presentations. The purpose of this study is to examine the density of the lung as measured by chest computed tomography (CT) and determine if…
- Trial name
- A1BC (NCT05297812)
- Where
- 9 sites in United States
- Volunteers
- 286 people
- Sponsor
- Columbia University
Coronary Artery Disease
IRIS-Synergy Cohort in the IRIS-DES Registry
The purpose of this study is to evaluate the relative effectiveness and safety of Synergy stent compared to other drug eluting stents.
- Trial name
- IRIS Synergy (NCT02720419)
- Where
- 28 sites in South Korea
- Volunteers
- 3,000 people
- Sponsor
- Jung-min Ahn
Child Health
Midline Catheter Study
The purpose of this study is to conduct a prospective longitudinal cohort observational study to analyze the catheterization success rate, catheter dwell time, as well as the incidence and risk factors of related complications in…
- Trial name
- NCT07610681
- Testing
- Mini midline catheters
- Where
- China
- Volunteers
- 428 people
- Sponsor
- Children's Hospital of Fudan University
Acute Appendicitis
MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA…
- Trial name
- observational (NCT04615728)
- Testing
- laparoscopic or open appendicectomy
- Where
- United Kingdom
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
COVID 19
Safe Return to Regular Clinical Operation After COVID-19 Pandemic
. Coronavirus (SARS-CoV2) appeared first in China late 2019 and caused an acute respiratory disease referred to as Coronavirus disease 2019 (COVID-19).
- Trial name
- NCT04377802
- Testing
- molecular testing for virus RNA using RT-PCR
- Where
- Saudi Arabia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- King Fahad Specialist Hospital Dammam
Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding
Comparison of Sedated and Unsedated PEG in Elderly ASA IV Patients
This prospective observational cohort study aims to compare the safety and clinical outcomes of sedated and unsedated percutaneous endoscopic gastrostomy procedures in elderly patients classified as ASA IV.
- Conditions
- Percutaneous Endoscopic Gastrostomy, Enteral Nutrition Feeding, Dysphagia, Elderly Patients (>65 Years)
- Trial name
- NCT07758153
- Volunteers
- 70 people
- Sponsor
- Mersin University
Appendicitis
Recurrent Appendicitis Following Successful Drainage of Appendicular Abscess in Adult
COVID-19 infection is a global pandemic that locked down hospitals and made patients fear to consult for medical health problems especially acute abdominal pain.
- Trial name
- NCT05048745
- Testing
- interval appendectomy
- Where
- Egypt
- Volunteers
- 316 people
- Sponsor
- Zagazig University
Health Behavior, Biomedical Technology
Biological Age in Worksite Health Promotion
This cohort study investigates how implementation of Biological Age technology in worksite health promotion, affects health behavior in the general Danish working population.
- Trial name
- BA1 (NCT03529357)
- Where
- Denmark
- Volunteers
- 5,473 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Environmental Exposure, Infertility
The Effect of Periconceptional Phthalates Exposure on Couples' Reproductive Health
The study is a prospective cohort study, which is aiming to explore periconceptional phthalates exposure and its potential epigenetic effect on fertility, embryo development, and neonatal outcomes.
- Trial name
- NCT03679000
- Where
- China
- Volunteers
- 2,122 people
- Sponsor
- Tongji Hospital
Solid Tumor, Advanced Solid Tumor
A Phase 1 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway
This is a Phase 1, open-label, multicenter, study evaluating the safety, tolerability, PK, PD, and anti-tumor activity of MRTX0902 alone and in combination with MRTX849 (adagrasib) in patients with advanced solid tumor malignancy…
- Conditions
- Solid Tumor, Advanced Solid Tumor, Non Small Cell Lung Cancer, Colo-rectal Cancer
- Trial name
- NCT05578092
- Testing
- MRTX0902, MRTX849
- Where
- 18 sites in United States, Puerto Rico
- Volunteers
- 64 people
- Sponsor
- Mirati Therapeutics Inc.
Spinal Cord Injuries
Determine the Association Between the Level of SCI With Chronic Respiratory Symptoms, Measures of Pulmonary Function, and Respiratory Illness.
This study is using a standardized method to assess respiratory function in SCI in order to determine the association between level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory…
- Trial name
- NCT00011336
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- US Department of Veterans Affairs
Atrial Fibrillation, Ischemic Stroke
Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs Warfarin)
The purpose of this study is to assess safety and effectiveness of direct oral anticoagulants (DOACs) and warfarin for stroke prevention in patients with non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Systemic Embolization, Major Bleed
- Trial name
- NCT03596502
- Testing
- Direct oral anticoagulants (DOACs), Warfarin
- Where
- Canada
- Volunteers
- 402,764 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Meniscus Injury, Knee Osteoarthritis
Knee Arthroscopy Cohort Southern Denmark (KACS)
PURPOSE: To investigate the natural time course of patient-reported outcomes after meniscus surgery and identify factors associated with good and bad outcome after surgery.
- Trial name
- KACS (NCT01871272)
- Testing
- Arthroscopic Meniscus Surgery
- Where
- 4 sites in Denmark
- Volunteers
- 491 people
- Sponsor
- University of Southern Denmark
Aortic Dissection Type A, Acute Kidney Injury Cardiac Surgery
Preoperative Ankle-Brachial Index and Renal Adverse Events After Acute Type A Aortic Dissection Surgery
This single-centre retrospective observational cohort study evaluated the association between preoperative cuff-derived ankle-brachial index (ABI) and postoperative acute kidney injury (AKI) in adults undergoing emergency repair…
- Trial name
- NCT07668830
- Testing
- Preoperative Ankle-Brachial Index
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Healthy
Gastrointestinal Tolerance And General Health Status Of Healthy Term Infants Fed A New Infant Formula
The purpose of this study is to assess stool consistency, in combination with additional health-related parameters including gastrointestinal tolerance and health-related quality of life, in a large sample of Chinese infants.
- Trial name
- NCT01370967
- Testing
- Study formula feeding, Human milk feeding, Mixed feeding
- Where
- 24 sites in China
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Crohn Disease, Recurrence
Extended Mesenteric Excision in Ileocolic Resections for Crohn's Disease
The study is looking at the role of the mesentery in disease recurrence for ileocolic Crohn's disease. It is a prospective study that has been designed to perform extended mesenteric excision on patients undergoing their first…
- Conditions
- Crohn Disease, Recurrence, Crohn's Ileocolitis
- Trial name
- NCT04266600
- Testing
- Extensive mesentery resection
- Where
- 2 sites in Canada
- Volunteers
- 29 people
- Sponsor
- Jewish General Hospital
Styloid-Stylohoid Syndrome, Temporomandibular Disorder
Evaluation of Styloid Chain Calcification to the Patient With the Temporomandibular Joint Disorder
The aim of the study was to evaluate any relation between elongated styloid process (ESP) and type of Temporomandibular Joint Disorders (TMD).
- Trial name
- NCT04280107
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Nuh Naci Yazgan University
Neoplasms
A Study of ZSTK474 in Japanese Patients With Advanced Solid Malignancies
To evaluate the safety (adverse events and dose-limiting toxicity) of daily oral doses of ZSTK474 in patients with advanced solid malignancies.
- Trial name
- NCT01682473
- Testing
- ZSTK474
- Where
- 2 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Zenyaku Kogyo Co., Ltd.
Cervix, Dysplasia, HPV Infection
Retrospective Cohort Study of the Effectiveness of the Prophylactic Vaccine Against the Human Papilloma Virus in the Prevention of Recurrence in Women Who Have Received an Excisional Therapy by HSIL / CIN.
A retrospective cohort study of women treated by excisional therapy due to HSIL/ CIN at Clínico San Carlos Hospital between 2012-2018.
- Conditions
- Cervix, Dysplasia, HPV Infection, HPV Vaccine, Cervix Lesion
- Trial name
- VENUS (NCT04171505)
- Testing
- HPV vaccine
- Where
- Spain
- Volunteers
- 508 people
- Sponsor
- Hospital San Carlos, Madrid
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