Clinical trials: Cohort
Solid Tumor, Unresectable or Metastatic Melanoma
PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors
To obtain evidence of antitumor effect of CX-072 in combination with anticancer therapy in adult patients with solid tumor based upon overall response rate by Response Evaluation Criteria in Solid Tumors (RECIST)
- Trial name
- NCT03993379
- Testing
- CX-072, Ipilimumab
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 3 people
- Sponsor
- CytomX Therapeutics
Asthma
Utilizing CT Based Imaging Parameters of Body Composition to Understand Heterogeneity of Response to Biologic Therapies in Severe Asthma Cohorts
This study will utilize University of Michigan EMR data to form a retrospective cohort of severe asthma patients on biologic therapies for asthma with computed tomography (CT) imaging and known outcomes on therapy.
- Trial name
- NCT06922760
- Where
- 2 sites in United States
- Volunteers
- 233 people
- Sponsor
- University of Michigan
Infection, Human Immunodeficiency Virus
Fosamprenavir in Pts With Hepatic Impairment
APV10017 was a pharmacokinetic study that evaluated the pharmacokinetics, safety and tolerability of fosamprenavir/ritonavir (FPV/RTV) at reduced doses over 14 days in HIV-infected subjects with mild to moderate hepatic…
- Trial name
- NCT01054586
- Testing
- Intervention A Standard dose, Intervention B Reduced Dose, Intervention C
- Volunteers
- 167 people
- Sponsor
- GlaxoSmithKline
Congenital Heart Defects, Dysfunctional Right Ventricular Outflow Tract Conduits
Melody Transcatheter Pulmonary Valve Study: Post Approval Study of the Investigational Device Exemption Cohort
The primary objective is to confirm the long-term functionality of implantation of the Medtronic Melody TPV at 5 years is no worse than the historical control established through literature review.
- Trial name
- NCT00740870
- Testing
- Transcatheter Pulmonary Valve replacement
- Where
- 5 sites in United States
- Volunteers
- 171 people
- Sponsor
- Medtronic Cardiovascular
Clinical Use of PTH(1-84)
Adherence to PTH(1-84) Treatment (FP-002-IM)
The primary objective is: 1) to describe adherence (and the main factors influencing adherence) to PTH(1-84) treatment when prescribed in a normal clinical setting. The secondary objectives are: 1.
- Trial name
- NCT00478569
- Testing
- Parathyroid Hormone (PTH) (1-84)
- Where
- Denmark
- Volunteers
- 1,179 people
- Sponsor
- Takeda
Follicular Lymphoma
Rituximab + Immunotherapy in Follicular Lymphoma
This research study is studying several new investigational drug combinations as a possible treatment for follicular lymphoma. The drugs involved are: Rituximab Utomilumab Avelumab PF-04518600
- Trial name
- NCT03636503
- Testing
- Rituximab, Utomilumab, Avelumab
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Postoperative Pain, Total Shoulder Arthroplasty
Cohort 1 (TSA) of: A Multi-surgery Assessment of ZYNRELEF (HTX-011)
Cohort 1 (subjects undergoing total shoulder arthroplasty, TSA) of a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing different surgical…
- Conditions
- Postoperative Pain, Total Shoulder Arthroplasty, Multimodal Analgesia
- Trial name
- AMAZE (NCT06109415)
- Testing
- HTX-011, Bupivacaine Hydrochloride, MMA regimen
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Heron Therapeutics
Hemangioma
Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas
This study will attempt to determine how common liver hemangiomas are in children with infantile hemangiomas by comparing liver ultrasound results in patients with 1-4 cutaneous hemangiomas, 5 or more cutaneous hemangiomas, or at…
- Trial name
- NCT00374335
- Testing
- abdominal ultrasound, Dermatologic Examination
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Children's Mercy Hospital Kansas City
Ankylosing Spondylitis
Defining Remission With Etanercept in AS in Real Life Clinical Practice
Determine which remission criterion at Month 6 predicts remission at Month 12 the best.
- Trial name
- REACH AS (NCT02202850)
- Testing
- etanercept
- Where
- 29 sites in Belgium
- Volunteers
- 84 people
- Sponsor
- Pfizer
Psychiatric Disorder
Investigating Psychosocial Predictors & Employment Outcomes of Enhanced IPS Intervention
The purpose of this cohort study, using an existing database, is to seek to describe the relationship between psychosocial factors (independent variables) and employment outcomes (dependent variables) in a population of people…
- Trial name
- NCT04083404
- Volunteers
- 202 people
- Sponsor
- Queen Margaret University
Arthritis,Rheumatoid
Long Term Effects of an Early Response to Certolizumab Pegol (CZP, Cimzia®) in Rheumatoid Arthritis (RA) Patients
To determine if early clinical response at 12 weeks to Certolizumab Pegol (CZP, Cimzia ®) therapy in adult Rheumatoid Arthritis (RA) patients is a predictor of better long term clinical response at 18 months compared with a lack…
- Trial name
- RA-PROACTIVE (NCT01288287)
- Where
- 22 sites in Ireland, United Kingdom
- Volunteers
- 149 people
- Sponsor
- UCB Pharma
Estrogen Receptor-positive Breast Cancer, Musculoskeletal Complications
A Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS)
E1Z11 is a study to determine whether certain genetic information can predict which breast cancer patients will discontinue treatment with aromatase inhibitors (AIs) due to the development of musculoskeletal symptoms (MSS).
- Conditions
- Estrogen Receptor-positive Breast Cancer, Musculoskeletal Complications, Progesterone Receptor-positive Breast Cancer, Recurrent Breast Cancer
- Trial name
- NCT01824836
- Testing
- anastrozole
- Where
- 2 sites in United States
- Volunteers
- 1,046 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
HIV-1-infection
Study of Novel Antiretrovirals in Participants With HIV-1
Master protocol: The goal of this master clinical trial study is to learn how novel antiretrovirals (medicines that stop the virus from multiplying) affect the human immunodeficiency virus-1 (HIV-1) infection in people living…
- Trial name
- NCT05585307
- Testing
- Bavtavirine, B/F/TAF, Standard of Care (Substudy 01)
- Where
- 42 sites in United States, Dominican Republic and 1 more
- Volunteers
- 49 people
- Sponsor
- Gilead Sciences
HIV, Metabolic Syndrome
Incidence of HANA Conditions in HIV-infected Individuals
With the availability of effective anti-retroviral therapy, HIV-infected individuals are expected not to die of AIDS and have longer life expectancy.
- Conditions
- HIV, Metabolic Syndrome, Osteopenia, Osteoporosis
- Trial name
- NCT03483584
- Where
- Hong Kong
- Volunteers
- 215 people
- Sponsor
- Chinese University of Hong Kong
Freeze Dried Plasma in Healthy Volunteers
Ascending Doses of Autologous FDP vs FFP
Assess the safety of single infusions with RePlas FDP product at increasing fixed doses
- Trial name
- FDP (NCT02930226)
- Testing
- Autologous Freeze Dried Plasma (FDP), Fresh Frozen Plasma (FFP)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Peripheral Arterial Disease, Intermittent Claudication
High Intensity Interval Training In pATiEnts With Intermittent Claudication
This INITIATE study evaluates the use of high-intensity interval training as a treatment modality for patients with intermittent claudication - an ambulatory leg pain caused by narrowed arteries that supply the lower limbs.
- Trial name
- INITIATE (NCT04042311)
- Testing
- High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Cancer, Non Small Cell Lung Cancer
A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell Lung Cancer (VanSel-1)
The purpose of this study is to determine whether using two drugs together called vandetanib and selumetinib is effective in the treatment of cancer.
- Trial name
- NCT01586624
- Testing
- Vandetanib, Selumetinib
- Where
- 4 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- Cancer Research UK
Type 2 Diabetes (Treated With Exenatide or Other Oral Antidiabetic Therapies), Healthy Subjects (Treated With no Diabetes Therapies)
A Retrospective Cohort Study of Acute Pancreatitis in Relation to Use of Exenatide and Other Antidiabetic Agents
The purpose of this research was to assess the absolute and relative incidence of acute pancreatitis in persons initiating exenatide compared with persons initiating a different antidiabetic agent, and secondarily, persons…
- Trial name
- NCT01077323
- Testing
- exenatide, Other antidiabetic therapies, No diabetes therapy
- Where
- United States
- Volunteers
- 363,766 people
- Sponsor
- AstraZeneca
Colorectal Adenocarcinoma
Expanded Cohort for Metastatic Colorectal Cancer (MCRC) Using Bevacizumab + Everolimus
The purpose of this study is to find the safest and most effective dose of the drugs bevacizumab and everolimus given in combination for the treatment of metastatic colorectal cancer.
- Trial name
- BEV/EV (NCT00597506)
- Testing
- Bevacizumab, Everolimus
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Herbert Hurwitz
Neoplasms, Breast Neoplasms
This Study in Patients With Different Types of Cancer (Solid Tumours) Aims to Find a Safe Dose of Xentuzumab in Combination With Abemaciclib With or Without Hormonal Therapies. The Study Also Tests How Effective These Medicines Are in Patients With Lung and Breast Cancer
This is a study in adult patients with different types of cancer. The purpose of this study is to find a safe dose of: Xentuzumab in combination with abemaciclib Xentuzumab in combination with abemaciclib and hormonal therapies…
- Trial name
- NCT03099174
- Testing
- Xentuzumab, Abemaciclib, Letrozole
- Where
- 30 sites in United States, Denmark and 5 more
- Volunteers
- 133 people
- Sponsor
- Boehringer Ingelheim