Clinical trials: Cohort
Gout, Hyperuricemia
Safety and Efficacy Study of Intravenous Uricase-PEG 20
The purpose of this study is to assess the safety, pharmacokinetics and pharmacodynamics of single intravenous doses of Uricase-PEG 20.
- Trial name
- NCT01021241
- Testing
- Uricase-PEG 20
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- EnzymeRx
Pediatric Flexible Flatfoot
Clinical and Functional Outcomes After Subtalar Arthroereisis in Pediatric Flexible Flatfoot
Flexible flatfoot is common in children and adolescents. In some patients, the condition remains painful or limits activity despite non-surgical treatment.
- Trial name
- STA-PFF (NCT07803341)
- Testing
- Subtalar Arthroereisis
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Pavia
ANCA Associated Vasculitis
Multicenter Cohort Study of AAV in Hunan of China
This study aimed to explore the incidence of Anti-neutrophil cytoplasmic antibody (ANCA）-associated vasculitis (AAV) progression and its association with adverse consequences.
- Trial name
- NCT05315141
- Testing
- No Intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangya Hospital of Central South University
Rheumatoid Arthritis
Safety Study of Abatacept to Treat Rheumatoid Arthritis
The purpose of this study is to compare the incidence rates of infection, malignancy and death among patients with rheumatoid arthritis who are treated with abatacept and those who are treated with other anti-rheumatic…
- Trial name
- NCT01247766
- Volunteers
- 6,367 people
- Sponsor
- Bristol-Myers Squibb
Traumatic Brain Injury, Intracranial Hemorrhages
Andexanet Alfa for Reversal of Factor Xa Inhibitors in Traumatic Brain Injury: A Retrospective Single-Centre Study
Elderly patients on direct oral anticoagulants (DOACs), specifically factor Xa (FXa) inhibitors such as apixaban and rivaroxaban are at elevated risk of haematoma expansion following traumatic brain injury (TBI).
- Trial name
- AA-TBI (NCT07898982)
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- University Medical Centre Ljubljana
Ehlers-Danlos Syndrome
Evaluation of a Cohort of Patients With Ehlers-Danlos Syndrome Treated With Orthopedic Surgery (SED-eval)
The aim of this study is to assess the joint involvement (shoulder - ankle - knee - elbow - wrist) in patients with Ehlers-Danlos Syndrome and treated by surgery.
- Trial name
- SED-eval (NCT05137379)
- Testing
- A joint functional score based on the affected joint
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Exertional Heat Illness
Comparing Exertional Heat Illness Risk Factors Between Patients and Controls
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat.
- Trial name
- NCT05303142
- Testing
- Heat Tolerance Assessment
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Emergency Surgery
Risk Stratification for Abdominal Emergency Surgery: a Cohort Study
The goal of this retrospective observational study is to identify risk factors of unwanted outcomes (in-hospital morbidity and mortality) among patients undergoing emergency abdominal surgery.
- Trial name
- NCT06501170
- Testing
- Retrospective Data Analysis of Emergency Abdominal Surgery Outcomes
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Dental Caries
Effectiveness of Oral Health Education Programs Among School Children, Their Mothers and Teachers in Fayyum: Cohort Study
Cohort study to evaluate the effect of oral health educational program effect on oral health of school children, their mothers and teachers
- Trial name
- NCT05980273
- Testing
- Educational sessions
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Cairo University
HIV, Tuberculosis
Vicente Ferrer HIV Cohort Study
The VFHCS is a long-term prospective cohort study of HIV infected patients from a resource-poor rural setting in India. The aim of the study is to use data collected from routine clinical care in order to describe the…
- Conditions
- HIV, Tuberculosis, Cryptococcosis, Opportunistic Infections
- Trial name
- VFHCS (NCT02454569)
- Where
- India
- Volunteers
- 30,000 people
- Sponsor
- Rural Development Trust Hospital
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
Hormone therapy, or androgen deprivation therapy (ADT) is a standard way to treat prostate cancer. It works by reducing the amount of the main male sex hormone, testosterone in the body.
- Conditions
- Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer, Metastatic Hormone Sensitive Prostate Cancer
- Trial name
- NCT07005154
- Testing
- ASP5541, Prednisone, Prednisolone
- Where
- 54 sites in United States, China and 10 more
- Volunteers
- 218 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Severe Renal Impairment
Prophylactic Desmopressin Before Native Kidney Biopsy in Severe Renal Impairment
This study evaluated whether giving desmopressin before a native kidney biopsy reduces bleeding complications in adults with severe renal impairment (eGFR <30 mL/min/1.73 m²).
- Trial name
- NCT07840313
- Testing
- Desmopressin Acetate, NO DESMOPRESSIN
- Where
- Pakistan
- Volunteers
- 250 people
- Sponsor
- Sindh Institute of Urology and Transplantation
Obstructive Sleep Apnea
A Prospective Observational Cohort to Study the Genetics of Obstructive Sleep Apnea and Associated Co-Morbidities
The primary objective of this study is to build a well characterized cohort of patients that will be used to determine the genetic variants associated with obstructive sleep apnea (OSA)and its co-morbidities.
- Trial name
- NCT01857427
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Ulysses Magalang MD
Spinal Cord Injuries, Thromboembolism
Absorption of Rivaroxaban in Patients With Cervical Spinal Cord Injury
The primary objective of this study is to investigate the pharmacokinetic and -dynamic properties of rivaroxaban after oral administration in cervical spinal cord injury (SCI) individuals.
- Trial name
- rivaroxaban (NCT02970773)
- Testing
- Rivaroxaban Oral Tablet
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Diabetes Type 2, Obesity and Overweight
Gastric Emptying in Healthy Volunteers and GLP-1 Agonist Users
This observational study aims to determine the gastric emptying kinetics assessed by ultrasound in healthy volunteers after a standard breakfast and the state of the stomach after a clear liquid diet for 18 /24 hours in patients…
- Trial name
- aGLP1-GUS (NCT06987669)
- Testing
- Gastric Ultrasound
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Clinica Alemana de Santiago
Head and Neck Cancer
Towards A Better Paradigm for Head and Neck Cancer Treatment Applying Artificial Intelligence. HNC-TACTIC.
This will be an international, multicenter, retrospective, observational, and data-driven study using secondary data captured in EHRs.
- Trial name
- HNC-TACTIC (NCT05117775)
- Testing
- No intervention - Just description and predictive models
- Where
- Spain
- Volunteers
- 10,000 people
- Sponsor
- Savana Research
CKD, Renal Insufficiency Chronic
The CPH-MBD Cohort Dietary Substudy - Comparison of Methods for Dietary Registrations
The aim of the study is to assess the association between the calcium and phosphorus balance and the stage of kidney disease measured by creatinine clearence in patients with chronic kidney disease stage 4 and 5.
- Conditions
- CKD, Renal Insufficiency Chronic, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder, Pre-dialysis
- Trial name
- NCT07312981
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Copenhagen
Sarcopenia
Understanding Acute Sarcopenia
This study aims to characterise acute changes in muscle mass, strength, physical performance in hospitalised older adults. We will assess the impact of these changes upon physical function at three month follow-up, and assess for…
- Trial name
- NCT03858192
- Testing
- Colorectal surgery procedure, Emergency abdominal surgery, Antibiotics
- Where
- United Kingdom
- Volunteers
- 168 people
- Sponsor
- University of Birmingham
Sepsis, Septic Shock
Health Related Quality of Life After Intensive Care for Sepsis, a National Cohort Study.
The study aims to map the health-related quality of life (HRQoL) after intensive care for Sepsis with the hypothesis that it will be lower than that in the general population.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe
- Trial name
- NCT06368336
- Volunteers
- 210,484 people
- Sponsor
- Uppsala University Hospital
Breast Neoplasms, Sentinel Lymph Node
A Prospective Single-center Cohort Study "Preoperative Identification of Sentinel Lymph Nodes Using Contrast-enhanced CT Lymphography in Breast Cancer Patients"
The main hypothesis of this study is that contrast-enhanced CT lymphography can be used for preoperative visualization of sentinel lymph nodes in breast cancer patients.
- Trial name
- NCT04930692
- Testing
- Contrast-enhanced CT lymphography with the periareolar injection of iopamidol
- Where
- Russia
- Volunteers
- 31 people
- Sponsor
- Saint Petersburg State University, Russia
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