Clinical trials: Cohort
Crohn Disease
Fibrosis Associated Protein Inhibitor (FAPI) Radiotracer-based Imaging to Identify Fibrotic Intestinal Crohn's Disease
Crohn's Disease (CD) is a chronic inflammatory condition that can affect any part of the intestine and currently has no cure. It affects 6.8 million people worldwide with UK healthcare costs in excess of £1 billion per year.
- Trial name
- FATE-CD (NCT07152431)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Sepsis, Septic Shock
Prognostic Accuracy of qSOFA, SIRS, and EWSs for In-hospital Mortality in Emergency Department
Early identification of a patient with infection who may develop sepsis is of utmost importance. Unfortunately, this remains elusive because no single clinical measure or test can reflect complex pathophysiological changes in…
- Trial name
- PASSEM (NCT05172479)
- Testing
- Measurement of qSOFA score, Measurement of SIRS criteria, Measurement of NEWS
- Where
- 20 sites in Bahrain, Kuwait and 5 more
- Volunteers
- 3,274 people
- Sponsor
- Aseer Central Hospital
Acute Myocardial Infarction (AMI)
Coronary and Myocardial Evaluation by Cardiac CT for Acute Myocardial Infarction
Acute myocardial infarction (AMI) remains a major cause of mortality and morbidity worldwide. Although percutaneous coronary intervention (PCI) combined with guideline-directed medical therapy has substantially improved survival…
- Trial name
- COMET-AMI (NCT07537296)
- Testing
- Cardiac CT Follow-up and Echocardiographic Follow-up
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Extracorporeal Membrane Oxygenation Complication, Hemorrhage
Platelets and Extracorporeal Membrane Oxygenation Veno-venous
In severe lung or heart disease, ExtraCorporeal Membrane Oxygenation (ECMO) may be used temporarily and can be responsible for major haemorrhagic complications. Thrombocytopenia and possibly thrombopathy promote bleeding.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Blood Platelet Disorder, Thrombosis
- Trial name
- PLAT-VV-ECMO (NCT07580469)
- Testing
- blood draws
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Venous Thromboembolism, Venous Thromboses
Risk Stratification for Venous Thromboembolism in Hospitalized Medical Patients
Hospital-acquired venous thromboembolism (HA-VTE) is one of the leading preventable causes of in-hospital mortality, but prevention of VTE in hospitalized medical patients remains challenging, as preventive measures such as…
- Conditions
- Venous Thromboembolism, Venous Thromboses, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- RISE (NCT04439383)
- Where
- 3 sites in Switzerland
- Volunteers
- 1,353 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gynecologic Cancer, Myelosuppression Adult
G-CSF for the Prevention of Febrile Neutropenia in Gynecologic Cancer Patients
This study aims to analyze the effects of long-acting granulocyte colony stimulating factor (G-CSF) on the prevention febrile neutropenia (FN) in gynecologic cancer patients.
- Conditions
- Gynecologic Cancer, Myelosuppression Adult, Febrile Neutropenia, Chemotherapy-induced Neutropenia
- Trial name
- NCT03793205
- Testing
- Long-acting G-CSF, Short-acting G-CSF
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Lei Li
Covid19
Late Clinical Events Associated With COVID-19 Infection
Several publications document the occurrence of symptoms that persist or occur late. The identification of the observed clinical manifestations and their clinical and paraclinical description are essential to better understand…
- Trial name
- COCO-LATE (NCT04591613)
- Testing
- Questionnaire, Biocollection, Follow-up visit
- Where
- 12 sites in France, French Guiana
- Volunteers
- 1,000 people
- Sponsor
- Tourcoing Hospital
Inflammatory Myositis, Idiopathic Inflammatory Myositis
Follow-up of Patients With Inflammatory Myopathies Associated With a Biobank
Myositis are rare diseases for which the development of a cohort associated with a bank of biological samples (biobank) will allow for the conduct of researches to better delineate the underlying pathophysiology and find cures.
- Conditions
- Inflammatory Myositis, Idiopathic Inflammatory Myositis, Drug-induced Inflammatory Myositis
- Trial name
- MASC2 (NCT05454527)
- Where
- 2 sites in France
- Volunteers
- 4,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non Small Cell Lung Cancer
Nogapendekin Alfa Inbakicept for Advanced Non-Small Cell Lung Cancer
This is a phase 3, open-label, 4-cohort study (3 randomized cohorts and 1 single-arm cohort). Participants enrolled in each cohort will be treated as detailed below. Each study cohort will be analyzed separately.
- Trial name
- NCT03520686
- Testing
- NAI + Pembrolizumab, NAI + Nivolumab + Ipilimumab, NAI + Pembrolizumab + Carboplatin + Nab-paclitaxel or Paclitaxel
- Where
- 31 sites in United States
- Volunteers
- 102 people
- Sponsor
- ImmunityBio, Inc.
Stroke Patients, Tracheostomy
A Speaking-Valve-Based Decannulation Protocol for Tracheostomized Stroke Patients
To evaluate the feasibility of a speaking-valve-based decannulation protocol in tracheostomized stroke patients
- Trial name
- SVBDP-TSP (NCT07904169)
- Testing
- Decannulation Protocol
- Volunteers
- 207 people
- Sponsor
- Hongying Jiang, MD
HR+/HER2- Locally Advanced, Metastatic Breast Cancer
UK Ibrance Patient Program (IPP) Study
What are the real-world treatment patterns, patients' characteristics, clinical outcomes and healthcare resource utilisation associated with palbociclib treatment in the 3 years following initiation in United Kingdom patients…
- Trial name
- ROIS (NCT03921866)
- Testing
- Palbociclib
- Where
- 8 sites in United Kingdom
- Volunteers
- 191 people
- Sponsor
- Pfizer
Anti-Glomerular Basement Membrane Disease
Anti-Glomerular Basement Membrane Disease
This study aims to clarify the prognosis of the rare but severe condition anti-glomerular basement membrane disease (anti-GBM disease also known as Goodpastures disease).
- Trial name
- PRAGMATIC (NCT07018024)
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Gastrointestinal Dysfunction, Malnutrition
Postoperative GI Dysfunction and Nutrition in Malnourished Cancer Surgery Patients
This is a prospective two-center observational cohort study in adult patients undergoing major abdominal and/or pelvic oncologic surgery with pre-existing malnutrition.
- Conditions
- Gastrointestinal Dysfunction, Malnutrition, Delirium - Postoperative, Abdominal Neoplasm
- Trial name
- GIDNUT (NCT07622888)
- Testing
- Serotonin (e.g., serotonin adipinate), Standard Prokinetic Therapy (excluding serotonin)
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Arma Ltd.
Longevity, Preventive Medicine
Tirzepatide and Organ-specific Biological Aging
The purpose of this study is to evaluate blood-based measures of organ-specific biological age, with a particular focus on the brain, and to investigate their relationship with established clinical indicators of health and their…
- Conditions
- Longevity, Preventive Medicine, Biological Ageing
- Trial name
- NCT07906041
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Atria Research and Global Health Institute (ARGHI)
Central Sensitisation, Low Back Pain
Nociplastic Pain Symptoms and Sensory Profiles in Low Back Pain
Assessing associations between Sensory profiles and nociplastic pain symptoms, and assessing the prognostic value of sensory profiles in the development of nociplastic pain symptoms in a low back pain population.
- Trial name
- NCT05592405
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Vrije Universiteit Brussel
Breast Cancer Female
Immediate Breast Reconstruction Following Mastectomy (IRMA)
Based on data from the US Surveillance, Epidemiology and End Result Program (SEER), the rates of nipple-sparing mastectomy (NSM) have risen 202% since 2009.
- Trial name
- IRMA (NCT04390529)
- Testing
- quality-of-life questionnaire: BREAST-Q
- Where
- 15 sites in Switzerland
- Volunteers
- 515 people
- Sponsor
- Thurgau Breast Center
Pregnancy Related, Pregnancy Disease
Chinese Pregnant Woman Cohort Study (Offspring Follow-up)
Purpose: To investigate the growth and development status for children of 1 ~ 3 years old in China, and to explore and analyze the influencing factors of infant growth.
- Conditions
- Pregnancy Related, Pregnancy Disease, Pregnancy, Infant Development
- Trial name
- NCT04444791
- Where
- China
- Volunteers
- 1,978 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Congestive Heart Failure
Cohort of Heart Failure Patients
This is a prospective cohort study of patients with Heart Failure with an eighteen-month follow-up aimed to collect all demographic, clinical, biological and para-clinical data to study population characteristics, assess…
- Trial name
- LOOP-HF (NCT03422991)
- Testing
- Blood sampling and Quality of life questionnaire.
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Temporomandibular Joint Syndrome
Temporomandibular Joint (TMJ) Positioning Accuracy and Efficiency Using a Dental Compass.
This study is being performed to determine if the use of the Dental Compass Articular and its software will produce therapeutic splints for TMD accurately and successfully, compare favorably with a cohort treated without the…
- Trial name
- NCT06619574
- Testing
- 3D Analysis Group, Manual Analysis Cohort
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Dr. Dean Reeves Clinic
Chronic Neuropathic Pain
A Post Market Cohort to Assess the Performance of the Spinal Modulation Neurostimulator System for the Management of Chronic Neuropathic Pain of the Foot and/or Lower Leg
14-SMI-2013 is a post market, observational, questionnaire based study to assess the effectiveness of the commercially available Axium neurostimulator in the management of neuropathic pain of the foot and/or lower limb
- Trial name
- NCT02335489
- Testing
- Implantation with the commercially available Axium neurostimulator
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Abbott Medical Devices
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