Clinical trials: Cohort
Permanent Hypoparathyroidism
Quality in Patients With Permanent Hypoparathyroidism After Total Thyroidectomy
Quality of life study. The study with include all patients operated with total thyroidectomy between 2005-2015 in Uppsala-Örebro healthcare region, Sweden.
- Trial name
- NCT04998968
- Where
- Sweden
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Lung Neoplasms
The Impact of Physical Activity on the Postoperative Symptoms, Complications, and Quality of Life Among Lung Cancer
The purpose of this study is to examine the impact of physical activity on the postoperative symptoms, complication, and quality of life.
- Trial name
- NCT03705546
- Where
- South Korea
- Volunteers
- 1,050 people
- Sponsor
- Samsung Medical Center
Heart Failure, Systolic
Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin
The study measure multiple neurohormones in patients with heart failure being treated with Sacubitril/Valsartan in increasing doses over an 8 week period.
- Trial name
- NCT03553303
- Testing
- Sacubitril / Valsartan Oral Tablet
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal)
Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS).
- Conditions
- Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Respiratory Distress Syndrome of Newborn
- Trial name
- NCT07550218
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Vastra Gotaland Region
Type 1 Pediatric Diabetes
Description of the Evolution of a Cohort of Adolescents With Type 1 Diabetes Following Their Participation in Therapeutic Education Program Based on Social Cognitive Theory: Socio-cognitive Profile, Physiological Behaviour of Therapeutic Adherence and Quality of Life
Introduction: Therapeutic Patient Education (TPE) is the key of the interdisciplinary management of type 1 diabetes for adolescents, favoring their adherence and improving their quality of life and metabolic control.
- Trial name
- ETPACAP (NCT02859818)
- Testing
- therapeutic education program
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Covid19, Femur Fracture
Femoral frACturEs and COVID-19.
Retrospective cohort study comparing the early prognosis after surgically-treated proximal femur fragility fractures in patients affected and not affected by COVID-19.
- Conditions
- Covid19, Femur Fracture, Fragility Fracture
- Trial name
- FACE COVID-19 (NCT04657510)
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Enterobacteriaceae Infections, Carbapenem-Resistant Enterobacteriaceae Infection
Aztreonam-Avibactam in Immunocompromised Hosts
The goal of this observational study is to learn about the effectiveness and safety of aztreonam-avibactam (ATM-AVI), an antibiotic used to treat infections caused by highly resistant bacteria, in adults with weakened immune…
- Conditions
- Enterobacteriaceae Infections, Carbapenem-Resistant Enterobacteriaceae Infection, Immunocompromised Host, Drug Resistance, Multiple, Bacterial
- Trial name
- IMMUNO-AVI (NCT07890480)
- Testing
- Aztreonam-Avibactam, Ceftazidime-Avibactam Plus Aztreonam
- Where
- Argentina
- Volunteers
- 814 people
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Non Small Cell Lung Carcinoma NSCLC
Impact of Chemotherapy Dose Reductions on Survival Outcomes Among Older NSCLC Patients Without Actionable Mutations
Evidence suggests that appropriately selected older adults can tolerate standard-dose chemotherapy and achieve survival outcomes comparable to younger patients.
- Trial name
- NCT07369596
- Testing
- Progression free survival, Overall survival
- Where
- 4 sites in Hong Kong, Malaysia
- Volunteers
- 150 people
- Sponsor
- University of Malaya
Rotator Cuff Tears, Rotator Cuff Repairs
Variation in Humeral Head Bone Marrow Characteristics With Rotator Cuff Repair Healing
This study investigates correlations between humeral head bone marrow characteristics and tendon healing of rotator cuff repairs.
- Trial name
- NCT05106088
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Prostate Cancer
Identifying the Best Follow up Approach for People Who Have Had Treatment to Cure Newly Diagnosed Prostate Cancer
Over 20,000 patients a year in the UK get surgery or radiotherapy to cure their prostate cancer. These men then undergo regular check-ups to manage potential side effects and see if cancer recurs so it can be treated quickly.
- Trial name
- FOLLOW-UP (NCT07264088)
- Testing
- Hospital based follow up, Primary care based follow up, Planned shared care follow up
- Where
- United Kingdom
- Volunteers
- 100,000 people
- Sponsor
- Imperial College London
COPD
Time-based Register and Analysis of COPD Endpoints
The Time-based Register and Analysis of COPD Endpoints (TRACE) study is prospective cohort study aiming at evaluating COPD patients using simple basic tools normally used in the clinic at hand of any physician.
- Trial name
- TRACE (NCT03485690)
- Where
- Spain
- Volunteers
- 1,440 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Covid19
COVID-19 Vaccine Effectiveness in Albanian Health Workers
The purpose of this study is to evaluate the effectiveness of the COVID-19 vaccine in hospital based HWs in Albania. This will answer critical questions about the real-world performance of COVID-19 vaccines in one of the key…
- Trial name
- COVEAL (NCT04811391)
- Testing
- COVID-19 vaccine
- Where
- 3 sites in Albania
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Institute of Public Health, Albania
Osteochondral Lesion of Talus, Autologous Osteoperiosteal Transplantation
Autologous Osteoperiosteal Transplantation for the Treatment of Severe Osteochondral Lesions of the Talus
The goal of this clinical trial is to establish a multicenter prospective cohort of patients with severe osteochondral lesion of the talus (OLT), evaluate the clinical efficacy of autologous osteoperiosteal transplantation and…
- Trial name
- NCT06527482
- Testing
- Autologous Osteoperiosteal Transplantation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Sepsis, Infection
Improving Dosing of Vancomycin in Young Infants With Infections
Current dosing regimens for vancomycin result in many young infants not reaching the target level of vancomycin in the blood at steady state (when the blood is in equilibrium at 24-48 hours).The purpose of this study is to assess…
- Conditions
- Sepsis, Infection, Bacteremia
- Trial name
- VANCAPP (NCT04044703)
- Testing
- Vancomycin - model-based dosing regimen
- Where
- 4 sites in Australia
- Volunteers
- 44 people
- Sponsor
- Murdoch Childrens Research Institute
Multiple Rib Fractures, Isolated Blunt Thoracic Trauma
GNRI and PNI for Predicting Short-Term Outcomes in Older Adults With Multiple Rib Fractures
This prospective observational cohort study will evaluate whether the Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) can predict short-term clinical outcomes in adults aged 65 years or older with…
- Trial name
- NCT07823712
- Where
- Turkey (Türkiye)
- Volunteers
- 294 people
- Sponsor
- Ankara Etlik City Hospital
Alzheimer's Disease
Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment
The aim of this project is to follow cohort of patients with aMCI in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy…
- Trial name
- NCT00684281
- Testing
- Neurological and neuropsychological consultation, MRI, Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Gynecological Malignancy
A Study of RC48-ADC for the Treatment of HER2-expressing Gynecological Malignancies
This study will evaluate the effectiveness and safety of intravenous injection of RC48-ADC in the treatment of HER2 expression (HER2 positive and HER2 low expression) gynecological malignancies.
- Trial name
- NCT04965519
- Testing
- RC48-ADC
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RemeGen Co., Ltd.
Microvascular Dysfunction, Hypertrophic Obstructive Cardiomyopathy
Association Between Microvascular Resistance and Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy
About 60% of patients with hypertrophic cardiomyopathy have microvascular dysfunction. Microvascular dysfunction is directly related to prognosis in hypertrophic cardiomyopathy.
- Conditions
- Microvascular Dysfunction, Hypertrophic Obstructive Cardiomyopathy, Microcirculation Resistance
- Trial name
- NCT05671367
- Where
- China
- Volunteers
- 340 people
- Sponsor
- China National Center for Cardiovascular Diseases
Type A Aortic Dissection
Safety and Efficacy of Aortic Root Reinforcement Combined With Vascular Grafts Eversion and built-in Procedure (XJ-procedure) in Patients With Acute Type A Aortic Dissection (ADVANCED-XJ )
This is a retrospective study based on the data available in our hospital database for ATAAD patients from January 2020 to December 2021.
- Trial name
- NCT05751200
- Testing
- No Intervention.
- Where
- China
- Volunteers
- 183 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Rectal Cancer
Protocol: Reconstruct the Pelvic Peritoneum Using BPF
Background: Extralevator abdominoperineal excision (ELAPE) may cause various surgical complications including disruption of perineal wound, perineal hernia and adhesive small-bowel obstruction.
- Trial name
- PPRBPF (NCT04177407)
- Testing
- Standard laparoscopic ELAPE with pelvic peritoneal floor reconstruction using bladder peritoneum flap are to performed.
- Where
- China
- Volunteers
- 30 people
- Sponsor
- West China Hospital
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