Clinical trials: Cohort
Oral Habits, Oro-Facial Dysfunction
Oral Habits Effect on Orofacial Dysfunction and Oral Health Related Quality of Life.
The aim of the present study is to determine the effect of oral habits on orofacial dysfunction and oral health related quality of life among a group of Egyptian children.
- Trial name
- OHRQoL (NCT04575792)
- Testing
- Practicing oral habits
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Rectal Prolapse
LVMR Versus PSR for External FTRPin Elderly Patients
In frail patients with external full-thickness rectal prolapse (FTRP), the exact postoperative recurrence and functional result outcomes difference between Laparoscopic ventral mesh rectopexy (LVMR) and perineal stapler resection…
- Trial name
- NCT05915936
- Testing
- LVMR, PSR
- Volunteers
- 330 people
- Sponsor
- Zagazig University
Virus Diseases, Herpes Zoster
Intravenous Vitamin C in the Treatment of Viral Infection, Especially in the Treatment of Shingles
Chronic viral infections induce oxidative stress that can cause a number of concomitant diseases, e.g. cardio-vascular diseases or metabolic disorders.
- Trial name
- 168 (NCT00921934)
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Pascoe Pharmazeutische Praeparate GmbH
HIV
Kumasi Cohort Study
The main objective is to access efficacy of first and second line antiretroviral therapy (ART) and its determinants in patients treated at the Komfo Anokye Teaching Hospital in Kumasi (KATH), Ghana, and to compare the clinical…
- Trial name
- KCS (NCT01853657)
- Testing
- Virological monitoring
- Where
- Ghana
- Volunteers
- 3,000 people
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Resectable Non-small Cell Lung Cancer
A Prospective Cohort Study of Neoadjuvant Chemotherapy Plus Sintillumab in the Treatment of Resectable NSCLC
This study uses a prospective cohort design.Subjects are randomly divided into three groups (A, B, C) before surgery. Group A gets 3 cycles of sintilimab + chemo, Group B gets 2 cycles + 1 cycle, and Group C gets 1 cycle + 2…
- Trial name
- NCT06485557
- Testing
- sintilimab plus platinum-based chemotherapy
- Volunteers
- 90 people
- Sponsor
- Tang-Du Hospital
Hypersensitive, Molar Incisor Hypomineralization
Effect of Glass-Ionomer Sealing Technique on Hypersensitive Teeth With Molar Incisor Hypomineralisation
This single armed cohort study is aimed to assess the acceptance, durability and efficiency of glass-Ionomer sealing technique on hypersensitive MIH molars (TNI-3 \& 4a/b/c) clinically shortly (15 minutes) after the application…
- Conditions
- Hypersensitive, Molar Incisor Hypomineralization, Pit and Fissure Sealants
- Trial name
- MIH_GIC (NCT05945381)
- Testing
- GIC on MIH
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Post Stroke Spastic Hemiplegia
Overlooked Barrier To Discontinuing Bont-A Therapy
This study aims to evaluate patient adherence to botulinum toxin (BoNT-A) treatment and identify the factors contributing to its discontinuation.
- Trial name
- NCT07422428
- Testing
- provide information by phone
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Suleyman Demirel University
Dyspnea
Evaluation of the Impact of Lung Ultrasound on Mortality and Rehospitalization in Patients Admitted to the Emergency Department With Dyspnea
Dyspnea is a frequent reason for referral to emergency departments, leading to a 30-day mortality rate of up to 10% and a 3-month rehospitalization rate of over 30%.
- Trial name
- HOSPITALUS (NCT05787665)
- Testing
- phone call at 3 months
- Where
- France
- Volunteers
- 385 people
- Sponsor
- Hospices Civils de Lyon
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study
Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study.
- Trial name
- NCT07267767
- Testing
- nCRT, BMI, Distance from AV
- Volunteers
- 3,500 people
- Sponsor
- Northern Jiangsu People's Hospital
Sickle Cell Disease
Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.
The purpose of this study is to evaluate the Safety and Efficacy of DREAM01, a gene therapy for Sickle Cell Disease (SCD). The therapy consists of transplanting autologous CD34+ cells transduced ex vivo with a bifunctional…
- Trial name
- DREPAMIR (NCT07432867)
- Testing
- DREAM01 drug product, anti-inflammatory therapy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ocular Ischemia Syndrome
Early Diagnosis for Ocular Ischemia Syndrome Using Arterial Spin Labeling Magnetic Resonance Imaging Technique
1. To evaluate ocular blood perfusion status and the possibility of craniocerebral vascular lesions of patients with ocular ischemia syndrome (OIS) using arterial spin labeling (ASL) magnetic resonance imaging technique. 2.
- Trial name
- NCT03863171
- Testing
- Arterial spin labeling (ASL) magnetic resonance imaging, Fundus fluorescein angiography
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Friendship Hospital
Covid19, Obstetric Anesthesia
Obstetric Anesthesia Experiences in COVID-19 Positive Patients
At the end of 2019, a new coronavirus named COVID-19 (SARS-CoV-2), one of the lower respiratory tract samples was detected in China.
- Trial name
- NCT04691934
- Testing
- Anesthesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Turkiye Yuksek Ihtisas Education and Research Hospital
Liver Neoplasms
Liver Cancer Prognosis Investigation Study
This prospective cohort study is designed to explore the role of environmental, clinical, and genetic risk factors in the progression and prognosis of primary liver cancer (PLC).
- Trial name
- NCT06623734
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Sun Yat-sen University
Breast Cancer, Colo-rectal Cancer
The French E3N Prospective Cohort Study
The French E3N cohort was initiated in 1990 to investigate the risk factors associated with cancer and other major non-communicable diseases in women.
- Conditions
- Breast Cancer, Colo-rectal Cancer, Parkinson Disease, Asthma
- Trial name
- E3N (NCT03285230)
- Where
- France
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pompe Disease
Phrenic Nerve and Diaphragm Electrophysiology in Pompe Disease
Pompe disease is traditionally considered a lysosomal myopathy. However, increasing experimental and clinical evidence suggests involvement of the entire motor unit, including motor neurons, peripheral nerves, neuromuscular…
- Trial name
- NCT07664930
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Alopecia Areata, Alopecia Totalis
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic
The study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the patients and registry of a…
- Conditions
- Alopecia Areata, Alopecia Totalis, Alopecia Universalis, Alopecia Areata (& Ophiasis)
- Trial name
- NCT05098600
- Testing
- Exposure of interest
- Where
- Czechia
- Volunteers
- 123 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Type 2 Diabetes Mellitus, Cognitive Impairment
Efficacy and Safety of Canagliflozin in the Treatment of Type 2 Diabetes With Mild Cognitive Impairment
The prevalence of cognitive dysfunction in diabetic patients is high, which seriously affects the quality of life of patients, and early intervention is of great significance.
- Trial name
- NCT07711171
- Testing
- Canagliflozin group, Sitagliptin, Acarbose
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma
Dinaciclib and Akt Inhibitor MK2206 in Treating Patients With Pancreatic Cancer That Cannot Be Removed by Surgery
This randomized phase I trial studies the side effects and best dose of dinaciclib and Akt inhibitor MK2206 in treating patients with pancreatic cancer that cannot be removed by surgery.
- Conditions
- Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma, Stage III Pancreatic Cancer AJCC v6 and v7, Stage IV Pancreatic Cancer AJCC v6 and v7
- Trial name
- NCT01783171
- Testing
- Akt Inhibitor MK2206, Dinaciclib, Laboratory Biomarker Analysis
- Where
- 5 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)
Prosthetic Joint Infection, Severe Infection
Phage Safety Cohort Study
This cohort study aims to describe the adverse events related to the use of bacteriophages to treat serious infections, data from the literature being almost non-existent on this subject.
- Trial name
- PHA-SA-CO (NCT04650607)
- Testing
- Adverse event after injection of phages
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Anemia
TRANSFORM - Observational Cohort Study of Darbepoetin Alfa Use in European Union (EU) Hemodialysis Patients Switched From PEG Epoetin Beta
To describe the time course of hemoglobin concentration in EU hemodialysis patients switched from methoxy polyethylene glycol-epoetin beta (PEG epoetin beta; Mircera) to darbepoetin alfa (Aranesp).
- Trial name
- TRANSFORM (NCT01997892)
- Where
- 32 sites in Belgium, France and 5 more
- Volunteers
- 1,027 people
- Sponsor
- Amgen
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