Clinical trials: Cohort
Pancreatic Carcinoma
Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts
This study evaluates individuals without pancreatic cancer, but who have been determined to be at higher-than-average lifetime risk of developing pancreatic cancer to help detect pancreatic cancer or other cancers at an earlier…
- Trial name
- NCT06271291
- Testing
- Non-Interventional Study
- Where
- 11 sites in United States
- Volunteers
- 30,000 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
Prosthesis and Surgery Guide System for Personalized Total Knee Arthroplasty
The subject is planned to carry out the clinical trails of femoral condyle prosthesis, tibial tray prosthesis and meniscus prosthesis; At the same time, in order to achieve personalized precision bone resection, the clinical…
- Trial name
- NCT04963491
- Testing
- Personalized TKA prosthesis, Zimmer NexGen prostheses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Psoriatic Arthritis, Enthesitis
Immune-Competent Cell Manifestations in Psoriatic Arthritis Achilles Tendons
Tendon pathologies (enthesitis) are a characteristic component of psoriatic arthritis (PsA), and are observed in 35% to 50% of PsA patients. The Achilles tendon is one of the most commonly affected sites.
- Trial name
- IMPAACT (NCT03248284)
- Testing
- Tendon biopsy procedure
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Adult Solid Neoplasm
Selumetinib and Cixutumumab in Treating Patients With Advanced Solid Malignancies
This phase I clinical trial studies the safety and best dose of selumetinib and cixutumumab in treating patients with advanced solid malignancies.
- Trial name
- NCT01061749
- Testing
- Cixutumumab, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Health Related
Newborns From Patients Treated With ART (Assisted Reproductive Technology)
The Prospective Cohort Study for Newborns from patients treated with ART was set up to investigate the short- and long-term health consequences in Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University…
- Trial name
- NCT03993158
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Obesity, Childhood, Lifestyle Intervention
Obesity-fertility Cohort Study: Protocol for the Assessment of Children Aged 6-12 Years and Their Mothers
Maternal preconception obesity and adverse gestational metabolic health increase the risk of childhood obesity in offspring. A group of investigators from Université de Sherbrooke therefore developed a lifestyle intervention…
- Conditions
- Obesity, Childhood, Lifestyle Intervention, Preconception Care
- Trial name
- NCT06402825
- Testing
- Fit-for-Fertility program
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Breast Cancer (Early Breast Cancer), Cardiotoxicity
Cardiac Side Effects of Systemic Therapy in Early-Stage Breast Cancer
The goal of this observational study is to evaluate cardiac side effects in women with early-stage breast cancer who receive systemic chemotherapy and/or anti-HER2 therapy as part of their standard cancer care.
- Conditions
- Breast Cancer (Early Breast Cancer), Cardiotoxicity, Cancer Therapy-Related Cardiac Dysfunction
- Trial name
- C-BREAST-01 (NCT07588425)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih GURLER
Taste Disorders
Gustatory Modulators Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy
Identify possible modulators for developing gustatory dysfunction among a sample of depressed Egyptian adults (age from 20 to 50 years old) under anti-depressants therapy ( for at least 3 months) using a questionnaire ( appendix)…
- Trial name
- NCT04923425
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Gastric Cancer, Colorectal Cancer
Evaluation of Fecal Multi-target Biomarkers in the Screening of Digestive Tract Cancers
This study is a multi-center, observational study. Participants scheduled for gastroscopy and colonoscopy will undergo an epidemiological assessment and provide a stool sample prior to endoscopy for qualitative Fecal…
- Trial name
- NCT07600125
- Testing
- Qualitative Fecal Immunochemical Test (FIT), quantitative (FIT), and testing for new biomarkers
- Where
- 13 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Covid19, Surgery
The Effect of the Covid-19 Pandemic Among Operated Patients
This project covers several research aims and uses different research methods, such as cohort analyses.
- Trial name
- NCT04525716
- Testing
- COVID-19 infection status, Socioeconomic status
- Where
- Sweden
- Volunteers
- 300,000 people
- Sponsor
- Karolinska Institutet
Diabetic Foot Ulcer, Wound Healing
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery
This observational prospective cohort study will evaluate whether routine blood tests are associated with the functional quality of calcaneal bone marrow aspirate mesenchymal stem cells in adults undergoing clinically indicated…
- Conditions
- Diabetic Foot Ulcer, Wound Healing, Foot Ulcer Due to Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2
- Trial name
- IQF-BMA (NCT07802106)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Sao Francisco
Colorectal Cancer
Effect of Implementation of Enhanced Recovery After Surgery on 3-year Survival After Colorectal Surgery for Cancer
Several recent studies have shown that the Enhanced Recovery After Surgery (ERAS) protocol reduces morbidity and mortality and shortens the length of stay compared to conventional recovery strategy (pre-ERAS).
- Trial name
- RACCOR (NCT05002855)
- Testing
- Enhanced Recovery After Surgery (ERAS)
- Where
- France
- Volunteers
- 1,001 people
- Sponsor
- University Hospital, Grenoble
Ulcerative Colitis, Inflammatory Bowel Diseases
Comparison Between Infliximab and Adalimumab on Patients With Ulcerative Colitis
Anti-TNF (tumor necrosing factor) treatment with infliximab (IFX) and adalimumab (ADA) are established first-line biological therapies used in treatment of patients with ulcerative colitis (UC).
- Trial name
- NCT06269185
- Testing
- Infliximab, Adalimumab
- Where
- Sweden
- Volunteers
- 271 people
- Sponsor
- Vastra Gotaland Region
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Treatment
The Safety and Efficacy of Single Antiplatelet Therapy After Pipeline Flex with Shield for Intracranial Aneurysms
The objective of this study was to evaluate the safety and efficacy of single antiplatelet therapy after Pipeline flex with Shield stent implantation for intracranial aneurysms.
- Trial name
- NCT06474884
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Xuanwu Hospital, Beijing
Respiratory Function Tests，Heart Function Tests, Cardiopulmonary Function
Xiangya Cardiopulmonary Health and Disease Cohort
Xiangya Cardiopulmonary Health and Disease Cohort (XY-CPHDC) is a non-intervention study grounded in real-world data. It is designed as a bidrectional clinical cohort combined retrospective and prospective design, in order to…
- Trial name
- XY-CPHDC (NCT06972784)
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Imaging Biomarkers of Mild Traumatic Brain Injury: a Longitudinal Cohort Study
This longitudinal cohort study aims to detect the topographical nature of the white matter microstructure and resting state functional connectivity patterns across the whole brain in the evolution of pathology as a function of…
- Conditions
- Mild Traumatic Brain Injury, Posttraumatic Stress Disorder, Affective and Somatic Complaints, Cognitive Impairments
- Trial name
- NCT02868684
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Keratoconus
One-Year Outcomes After Conventional vs Accelerated Epi-Off Corneal Cross-Linking in Progressive Keratoconus (Observational Cohort)
Prospective, observational (consecutive eligible eyes) continuation of a previously published 6-month cohort from the same center, extending follow-up to 12 months.
- Trial name
- KCXL-1Y (NCT07194538)
- Where
- Croatia
- Volunteers
- 20 people
- Sponsor
- Clinical Hospital Centre Zagreb
Head and Neck Cancer
DOsimetry and Radiation Induced NAusea in Head and Neck Cancers
This is a prospective cohort study for the analysis of correlation between dosimetric parameters and RANV (Radiation Associated Nausea and Vomiting) in patients with head and neck cancer undergoing exclusive radiotherapy (RT).
- Trial name
- DORIAN (NCT06341985)
- Testing
- Exclusive radiotherapy
- Where
- 14 sites in Italy
- Volunteers
- 180 people
- Sponsor
- European Institute of Oncology
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