Clinical trials: Cohort
Diabetic Foot Ulcer (DFU), Diabete Mellitus
AI-Based Diabetic Foot Recurrence Cohort
Diabetic foot ulcer (DFU) is a major adverse outcome of diabetes, which itself is one of the most significant chronic diseases. The recurrence of DFU involves multiple risk factors, including altered foot loading patterns…
- Conditions
- Diabetic Foot Ulcer (DFU), Diabete Mellitus, Diabetic Foot Ulcer Treatment, Artificial Intelligence (AI) in Diagnosis
- Trial name
- NCT07452354
- Testing
- Researchers predefined groups based on risk stratification to formulate personalized follow-up strategies.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Bladder Cancer
Effect of Dietary, Lifestyle, and Environmental Factors on Patients With Early-Stage Bladder Cancer
RATIONALE: Learning about the long-term effects of dietary, lifestyle, and environmental factors on the risk of cancer progression and recurrence may help the study of bladder cancer in the future.
- Trial name
- NCT00553566
- Testing
- medical chart review, questionnaire administration, study of socioeconomic and demographic variables
- Where
- United Kingdom
- Volunteers
- 1,600 people
- Sponsor
- University of Birmingham
Postmenopausal Bleeding, Endometrial Cancer
Performance of Ultrasound in Women With Postmenopausal or Abnormal Uterine Bleeding Between White and Black Ethnic Groups- a Retrospective Cohort Study.
Primary Objective: To assess whether there is a higher incidence of uninformative ultrasound in black vs white women
- Trial name
- NCT06293066
- Testing
- Ultrasound
- Where
- United Kingdom
- Volunteers
- 330 people
- Sponsor
- King's College Hospital NHS Trust
Low Back Pain, Life Style
Prognostic Factors of Importance on Who Develops Chronic Low Back Pain
The incidence of low back pain (LBP) is increasing and prognostic factors for developing LBP are unclear. Based on questionnaires, different prognostic factors are being explored over time.
- Conditions
- Low Back Pain, Life Style, Illness Perception
- Trial name
- NCT03940456
- Testing
- Questionnaire
- Where
- Denmark
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Type 2 Diabetes
TODAY2 Phase 2 Follow-up
The primary objective of T2P2 is to track the progression of T2D and related comorbidities and complications in the TODAY cohort as they transition to young adulthood.
- Trial name
- T2P2 (NCT02310724)
- Testing
- TODAY cohort
- Where
- 15 sites in United States
- Volunteers
- 517 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Metabolic Syndrome X
a Population Based Study on Metabolic Syndrome Complications, and Mortality
Metabolic syndrome (MetS) is recognized as clustering of a number of components including hypertension, hypertriglyceridemia, low serum high-density lipoprotein cholesterol (HDL-C), impaired glucose metabolism (IGM), and…
- Trial name
- MetSCoM (NCT02958579)
- Testing
- No intervention will be done. Participants are on standard care and the treatments will be recorded because of observational nature of this study.
- Where
- Iran
- Volunteers
- 10,000 people
- Sponsor
- Tehran University of Medical Sciences
Pulmonary Disease, Chronic Obstructive
A Wearable and a Self-management Application for Chronic Obstructive Pulmonary Disease (COPD) Patients at Home
Our overall research goal for this project is to create a wearable device and mobile application, appealing to patients with Chronic Obstructive Pulmonary Disease (COPD), which provides them with appropriate self-management tools…
- Trial name
- COPDwear (NCT03857061)
- Testing
- smartphone, smartwatch, WearCOPDv2 application
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
An AI Model Predicts the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer: a Multicenter, Bidirectional Cohort Study
Neoadjuvant chemotherapy is an important part of the systematic treatment of breast cancer, and it is of great clinical significance to predict the efficacy of neoadjuvant chemotherapy in early stage.
- Trial name
- NCT06510127
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hepatitis C, HIV
Determination of HCV Prevalence in a HIV Patient Cohort in Phnom Penh, Cambodia
Hepatitis C (HCV) is an important global public health problem, disproportionately affecting HIV positive populations. Asia and Africa account for most of the co-infection burden, but access to HCV screening and treatment is…
- Trial name
- HCV-Epi (NCT02361541)
- Testing
- HCV screening
- Where
- Cambodia
- Volunteers
- 3,045 people
- Sponsor
- Institute of Tropical Medicine, Belgium
COVID-19, Post-COVID-19 Syndrome
Cohort Follow-up of Epidemic and Neuroimaging for Patients During the 1st Wave of the COVID-19 in China
Our main objective is to analyze the development of physical impact, mental health and blood profile over follow-up time during the 1st wave of the COVID-19.
- Conditions
- COVID-19, Post-COVID-19 Syndrome, Acute COVID-19, Post-Acute COVID-19
- Trial name
- NCT05745805
- Testing
- Simultaneous cortico-spinal magnetic resonance imaging, Serum
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Aortic Valve Stenosis
Hamburg AoRtic Valve cOhoRt
The primary aim of the study is to identify the optimal treatment modality for patients with aortic valve disease, incorporating the individual patient's risk profile and anticipated clinical outcomes.
- Trial name
- HARbOR (NCT04227002)
- Where
- Germany
- Volunteers
- 15,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Zika Virus
ZIKAlliance Children Cohort (ZIKAllianceCH)
The aim of this proposal is to evaluate the causal relationship between Zika virus (ZIKV) infections in pregnancy and congenital malformations.
- Trial name
- ZIKAllianceCH (NCT03393286)
- Where
- 10 sites in Bolivia, Brazil and 5 more
- Volunteers
- 1,554 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Alzheimer Disease, Mild Cognitive Impairment
ADRC Clinical Cohort (Alzheimer's Disease)
The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06703541
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Duke University
Growth Hormone, Advanced Maternal Age
Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study
This retrospective cohort study aims to investigate the effects of recombinant human growth hormone (rh-GH) on the euploid status of preimplantation blastocysts in AMA patients.
- Conditions
- Growth Hormone, Advanced Maternal Age, PGT-A
- Trial name
- NCT05574894
- Testing
- Growth hormone, GnRH antagonist
- Where
- China
- Volunteers
- 692 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Ovarian Neoplasm
Study to Evaluate the Safety and Efficacy of TSR-042, Bevacizumab, and Niraparib in Participants With Recurrent Ovarian Cancer
The primary objective of this sub study is to evaluate the efficacy of the combination of TSR-042, bevacizumab, and niraparib in participants with advanced, relapsed, high-grade ovarian, fallopian tube, or primary peritoneal…
- Trial name
- COHORT-A (NCT05751629)
- Testing
- Dostarlimab, Bevacizumab, Niraparib
- Where
- 10 sites in United States
- Volunteers
- 41 people
- Sponsor
- Tesaro, Inc.
Human Immunodeficiency Virus
A Study of Raltegravir in a Diverse Cohort of HIV-Infected Patients (0518-055)
A study to test the safety and effect of twice daily raltegravir in a diverse cohort of patients currently infected with human immunodeficiency virus (HIV), where at least 50% are African American and at least 25% are female…
- Trial name
- NCT00764946
- Testing
- Comparator: raltegravir
- Volunteers
- 209 people
- Sponsor
- Merck Sharp & Dohme LLC
Solid Tumor
Cohort Study: Modelling Toxicity Processing in Patients Treated by Immunotherapy (MOTIVATE).
This trial is a multicentric, prospective cohort study of 150 patients aiming to model evolution of toxicity over time in patients with solid tumor and starting first cycle of Immune Checkpoint Inhibitor (ICI) treatment.
- Trial name
- MOTIVATE (NCT03447483)
- Testing
- Patients starting a treatment by ICI
- Where
- 6 sites in France
- Volunteers
- 150 people
- Sponsor
- Institut Claudius Regaud
Sepsis, Septic Shock
Immune Dysregulation During Sepsis: A Natural History Cohort
Background: Sepsis is an illness that occurs when the body s immune system runs out of control. This can damage organs. Sepsis causes an estimated 1 in 5 deaths worldwide.
- Conditions
- Sepsis, Septic Shock, Sepsis-Associated Immune Dysregulation
- Trial name
- NCT07735741
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sepsis, Sepsis-induced Coagulopathy
Early Detection and Kinetics of Sepsis-Induced Coagulopathy in Severe Burn Patients
Sepsis is a major and life-threatening complication in patients with severe burn injuries, frequently progressing to sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC).
- Conditions
- Sepsis, Sepsis-induced Coagulopathy, Disseminated Intravascular Coagulation, Burns
- Trial name
- SIC-BURN-JAAM2 (NCT07914205)
- Testing
- Prospective calculation and kinetic monitoring of the revised Japanese Association for Acute Medicine (JAAM-2) score using biological parameters (platelet count/kinetics, PT/INR, D-dimer/FDP) measured
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Center for Traumatology and Major Burns, Ben Arous
Locally Advanced Rectal Carcinoma
A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer
The goal of this clinical trial is to compare the efficacy and safety of neoadjuvant chemoradiotherapy combined with tirelizumab compared with neoadjuvant chemoradiotherapy alone for neoadjuvant therapy in patients with locally…
- Trial name
- NCT06312982
- Testing
- Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 375 people
- Sponsor
- Beijing Friendship Hospital
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