Clinical trials: Cohort
SARS-CoV-2, COVID-19
Epidemiology, Immunology and Clinical Characteristics of COVID-19 (EPIC3)
The purpose of this research is to gather information to answer questions about the Coronavirus Disease 2019 (COVID-19) which is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection.
- Trial name
- EPIC3 (NCT05764083)
- Where
- United States
- Volunteers
- 2,824 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Melanoma
Study of HL-085 in NRAS Mutant Advanced Melanoma
This is a phase I/II, open-label, dose escalation study to evaluate tolerability, safety, pharmacokinetics and efficacy in patients with NRAS mutant advanced melanoma .
- Trial name
- NCT03973151
- Testing
- HL-085
- Where
- 2 sites in China
- Volunteers
- 42 people
- Sponsor
- Shanghai Kechow Pharma, Inc.
Hepatectomy
Use of Transcollation Device to Decrease Blood Loss During Hepatic Resections: a Randomized Cohort Study (HEPACOLL)
Blood loss in hepatic surgery is the main factor of postoperative morbidity. The use of the most effective possible tool for hemostasis allows a bleeding decrease during liver transection and thus could reduce postoperative…
- Trial name
- NCT01874639
- Testing
- standard bipolar coagulation, Aquamantys® probe for liver hemostasis
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
Low Back Pain, Type of Leg Pain (Radicular, Non-radicular)
The Course of Low Back Pain
This study aims to research the possible associations of education level, sedentary lifestyle, and type of low back pain (radicular vs non-radicular) with the course of low back pain and recovery rate.
- Conditions
- Low Back Pain, Type of Leg Pain (Radicular, Non-radicular), Lifestyle (Sedentary Behavior and Physical Activity), Start Back Screening Tool
- Trial name
- NCT04419675
- Testing
- Observational Cohort, usual care = physical therapy
- Where
- 6 sites in Netherlands
- Volunteers
- 347 people
- Sponsor
- Radboud University Medical Center
HIV-1-infection
Zadaxin and HIV-positive Patients With Immune Reconstitution Disorder
The purpose of this study is to evaluate the safety and efficacy of Zadaxin® in the treatment of HIV-positive patients with immune reconstitution disorders.
- Trial name
- NCT04963712
- Testing
- Zadaxin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Public Health Clinical Center
Advanced Cancers (Breast, Ovarian, mCRPC, Pancreatic Ductal Adenocarcinoma (PDAC), Brain Mets) With Specific Mutations (Homologous Recombination Deficiency)
Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies
Open label, multi-centre, Phase Ia/b adaptive design study with an initial 2-stage Dose Escalation Phase followed by a Dose Expansion Phase.
- Trial name
- NCT06458712
- Testing
- DSB2455
- Where
- 21 sites in United States, France and 3 more
- Volunteers
- 180 people
- Sponsor
- Duke Street Bio Ltd
Intrapartum Maternal Fever, Clinical Chorioamnionitis
Association Between Neuraxial Labor Analgesia and Maternal and Neonatal Infectious Outcomes
The goal of this retrospective observational cohort study is to explore the associations between neuraxial labor analgesia and maternal-neonatal infectious outcomes among women attempting vaginal delivery, and to distinguish…
- Conditions
- Intrapartum Maternal Fever, Clinical Chorioamnionitis, Neonatal Infection
- Trial name
- NCT07751666
- Testing
- neuraxial labor analgesia
- Volunteers
- 49,000 people
- Sponsor
- Peking University First Hospital
Antichlamydial Antibodies, Chlamydia Trachomatis Infection
Cohort Study Investigating the Association Between Antichlamydial Antibody Positivity and ART Outcomes in Women With TFI
In a prospective cohort study investigators will examine characteristics and clinical outcomes of treatment with ART in women with tubal factor infertility (TFI) with regard to seropositivity to antichlamydial antibodies.
- Conditions
- Antichlamydial Antibodies, Chlamydia Trachomatis Infection, Infertility, Tubal Factor Infertility
- Trial name
- NCT04139629
- Testing
- antichlamydial antibody test, treatment of infertility with ART
- Where
- Russia
- Volunteers
- 292 people
- Sponsor
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Rheumatoid Arthritis
Prospective Cohort Study on Refractory Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic erosive arthritis. Without timely and appropriate treatment, it can lead to joint destruction and disability.
- Trial name
- NCT07126431
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Lymphoma, Multiple Myeloma
Analysis of Data Collected in the European Group for Blood and Marrow Transplantation (EBMT) Registry on a Cohort of Patients Receiving Plerixafor
In the European Union (EU), plerixafor is indicated in combination with granulocyte colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells (HSCs) to the peripheral blood (PB) for collection and…
- Trial name
- NCT01362972
- Volunteers
- 7,801 people
- Sponsor
- Genzyme, a Sanofi Company
Heart Failure With Preserved Ejection Fraction, Chronic Pulmonary Thromboembolism (Disorder)
The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
To evaluate the role of exercise hemodynamic testing in the diagnostic workup for patients with dyspnea on exertion referred to the catheterization lab.
- Trial name
- EX_CATH (NCT05490901)
- Testing
- Exercise hemodynamic test
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Radiation Treatment, Neurovascular Complications
Long-term Neurovascular Complications After Radiation Therapy in Head and Neck Cancer
Head and neck cancer is a group of cancers develop from the soft tissues, salivary gland, mucosa of the upper respiratory or digestive system covering the oral and nasal cavity.
- Trial name
- NCT06111430
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- Chang Gung Memorial Hospital
Frailty, Muscle Weakness
Prognostic Value of Exhaled Isoprene Levels for Morbidity and Functional Outcome in Cardiosurgical Patients
The perioperative preservation of functionality and quality of life plays an increasingly important role in older physically limited and frail patients undergoing cardiac surgery.
- Conditions
- Frailty, Muscle Weakness, Volatile Organic Compounds, Isoprene
- Trial name
- PREDICT (NCT06175429)
- Testing
- Physical performance testing, Breath sampling and VOC analysis, Muscle ultrasound
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- University of Rostock
Urinary Tract Dilatation
Retrospective Evaluation of a Cohort of Patients Diagnosed With Pre- and Postnatal Urinary Dilatation: Outcome and Long-term Follow-up
Retrospective evaluation of a cohort of patients diagnosed with pre- and postnatal urinary dilatation: outcome and long-term follow-up
- Trial name
- NCT06764472
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Biomarkers of Diabetic Retinopathy
Study of Natural Course Progression of Diabetic Retinopathy
The goal of this observational study is to observe the formation and development of the non-perfusion area of diabetic retinopathy in the posterior area of the retina in type 2 diabetes patients aged 18-75 years old, who can…
- Trial name
- NCT06269419
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jie Li
NSCLC, Advanced Solid Tumor
YSCH-01 Via Nebulization in Pulmonary Metastasis of Advanced Solid Tumors and Non-small Cell Lung Cancer (NSCLC)
This is an open-label, dose-escalation and cohort expansion study to evaluate the safety and preliminary efficacy of YSCH-01 in subjects with pulmonary metastasis of advanced solid tumors and advanced non-small cell lung cancer…
- Trial name
- NCT07793500
- Testing
- YSCH-01
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Congenital Heart Disease
Perioperative Outcome of Congenital Heart Disease Surgery in Childhood
Congenital heart disease is the most common congenital malformation in the world with high morbidity and mortality. However, there is no data to assess the perioperative outcome of congenital heart disease surgery among Chinese…
- Trial name
- NCT04093011
- Testing
- Congenital Heart Disease Surgery
- Where
- China
- Volunteers
- 6,500 people
- Sponsor
- Nanjing Medical University
Arthroplasty, Replacement, Knee
Silkeborg Knee Replacement Cohort Study
In this cohort study, we will investigate short and long term outcomes after knee replacement surgery and identify preoperative and early postoperative factors associated with long term outcome.
- Trial name
- NCT03411083
- Testing
- Total or unicompartmental knee replacement
- Where
- Denmark
- Volunteers
- 1,225 people
- Sponsor
- Central Jutland Regional Hospital
Clinical Study, Chronic Functional Constipation
Effect of Vibration Capsule on Different Subtypes of Functional Constipation
This study is a multi-center prospective cohort study, which plans to include 600 patients with chronic functional constipation to treat with Vibrabot capsules and patients will be grouped according to subtypes.
- Trial name
- NCT06408883
- Testing
- Vibrabot capsule
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Changhai Hospital
Autism Spectrum Disorder
Care Pathway for Children With Autism Spectrum Disorder Included in the ELENA Cohort
Autism Spectrum Disorder (ASD) is lifelong neurodevelopmental disorder that affect social communication and interaction and includes limited and repetitive patterns of behavior (DSM 5).
- Trial name
- ELENA-SNDS (NCT04292522)
- Where
- France
- Volunteers
- 903 people
- Sponsor
- University Hospital, Montpellier
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